Plenary V

Exercise therapy offers multiple mechanisms of benefit in chronic pain. Physiologically, it modulates pain processing through central and peripheral mechanisms, including the activation of endogenous analgesic systems, the reduction of inflammatory mediators, and neuroplastic changes in the nervous system. Psychologically, physical activity can reduce fear-avoidant behaviors, improve mood, and enhance patients' sense of control over their symptoms. However, several challenges remain in implementing exercise therapy. To overcome these barriers, healthcare professionals need to understand its analgesic mechanisms and how to apply it effectively in clinical settings.
This lecture aims to present the latest findings on the mechanisms by which exercise therapy exerts analgesic effects in the treatment of chronic pain, with a focus on recent neurobiological research conducted by the presenters. In addition, practical aspects of exercise-based interventions will be discussed through illustrative clinical cases. The target audience includes physicians, physical therapists, nurses, pharmacists, and researchers. By integrating both basic and clinical perspectives, the session will promote a deeper understanding of the role of exercise therapy within interdisciplinary pain management.
This lecture will encourage the development of accessible, sustainable, and patient-centered interventions that can be applied across diverse healthcare settings, including low- and middle-income settings.

Voltage-gated sodium channels have been long a promising target for pain pharmacotherapy, particular in neuropathic pain. Dr Lampert and others have contributed to substantial increase in understanding the physiological and functional aspects of these channels, that can allow more precise targeting for pain. In addition, given the FDA approval of a novel NAV-blocking medicine for pain, an in-depth dive on the topic is more than timely.