399: Comparative study between the effects of dexmedetomidine, lignocaine infusion in upperlimb surgeries

Topic: Clinical Science
Subtopic: Pain category (ICD-11), Acute postsurgical pain, Developing methodology/technology, Pharmacological treatments, Assessment and Measurement of Pain/Nociception

Background and Aims: Objectives:
1, To compare the intraoperative and postoperative hemodynamics
2,requirement of nalbuphine for postoperative
analgesia in upper limb orthopedic surgeries.
3,utilized non-opioid analgesic adjuncts such as dexmedetomidine and lidocaine in the perioperative periods to curtail the use of opioids as a part of enhanced recovery after surgery protocol
4,minimize opioid-related adverse events.

Study Design
Comparative analytical study
Place and duration of study:
Department of Anesthesia, Fauji Foundation Hospital, Rawalpindi, Pakistan 7th Oct 2022 to 15th
July 2023.

Methods: Methodology:
Patients undergoing upper limb orthopedic surgeries in our tertiary care setup. Ninety patients undergoing
upper limb orthopaedic surgeries were divided into two equal groups of forty-five patients each. Group A received
Dexmedetomidine infusion, while Group B received Lidocaine infusion. Data collection involved gathering information
related to upper limb orthopaedic procedures, including both intraoperative and postoperative parameters.

Results: Ninety patients undergoing upper limb surgeries were randomized divided into two groups (Dexmedetomidine:( GroupA)
Lidocaine: Group B).
Group A experienced statistically significant reductions in intraoperative mean arterial pressure
(MAP) by 20% (p<0.05) and heart rate (HR) by 15% (p<0.01) compared to Group B at all time points (10-120 minutes).
Postoperative pain scores were significantly higher in Group B (mean difference: 1.5 points, p<0.001) across all time points
(2-24 hours). Group A also exhibited significantly higher sedation scores (mean difference: 2 points, p<0.001) and required
significantly less postop-analgesia (one dose vs. multiple doses, p<0.001) than Group B.

Conclusions: Conclusion:
The findings affirm dexmedetomidine infusion's advantages in achieving optimal outcomes: improved
hemodynamics, reduced pain, and lowered postoperative analgesic demands, reinforcing its role in effective pain management.

References: REFERENCES
1. Ghosal, A., Debnath, T., Chakraborty, S., Das, D., Laha, A.,
Mandal, M., & Acharjee, A. (2024). Comparative study
between the effect of dexmedetomidine and lidocaine infusion
on intraoperative analgesic requirement and hemodynamics
during craniotomy. Asian Journal of Medical Sciences, 15(1)
2,Xu S, Wang S, Hu S, Ju X, Li Q, Li Y. Effects of lidocaine,
dexmedetomidine, and their combination infusion on
postoperative nausea and vomiting following laparoscopic
hysterectomy: a randomized controlled trial. BMC Anesthesiol.
2021 Dec 1;21(1). https://doi: 10.1186/s12871-021-01420-

Presenting Author: Dr Komal mumtaz
Submitting Author: Komal Babur

Senior Author: Dr liaqat Ali

IASP 2026 Global Year theme of Neuropathic Pain: No