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Poster Session 4 (Wednesday Afternoon)

Mechanical–Molecular Remodeling of Hippocampal ECM in Neuropathic Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Maral Tajerian
Presenting Author: Chuang Ge
Submitting Author: Chuang Ge

Description:

Peripheral nerve injury induces neuropathic pain characterized by persistent mechanical hypersensitivity and long-lasting central nervous system remodeling. Although neuronal plasticity has been extensively investigated, the contribution of extracellular microenvironment remodeling to pain chronification remains insufficiently understood. The hippocampus, involved in cognitive dimensions of pain, exhibits structural and synaptic plasticity in chronic pain states. Emerging evidence suggests that extracellular matrix (ECM) remodeling regulates synaptic stabilization, neuro–immune signaling, and tissue biomechanics; however, its spatial biomechanical–molecular organization during neuropathic pain progression remains unclear. This study aimed to establish a correlative multimodal platform to define region-specific hippocampal ECM remodeling during pain chronification.

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Cav-1 in the dorsal root ganglion modulates neuropathic pain via regulation of dopamine D1 receptor

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Qing Liu, Ying Zhang
Presenting Author: Chunyan Cui
Submitting Author: Chunyan Cui

Description:

Neuropathic pain has become the most common type of chronic pain, but its pathophysiological mechanism remains unclear, and there are currently no effective treatment methods in clinical practice. Increasing evidence indicates that the plasticity changes of dorsal root ganglion (DRG) neurons are the core feature of neuropathic pain. In our previous study, we used bioinformatics methods to screen out key genes related to neuropathic pain in rat DRG, among which the expression of Caveolin-1 (Cav-1) showed significant differences. Cav-1 is an important structural protein of membrane lipid rafts and participates in various signal transduction processes, but its specific role in neuropathic pain is still unclear. This study aims to explore the expression changes of Cav-1 in neuropathic pain and its possible mechanisms, with a particular focus on its regulatory effect on the dopamine D1 receptor, in order to provide new targets for clinical intervention.

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Brain-Wide Activity Patterns Underlying Individual Differences in Chronic Pain Expression

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Loren Martin
Presenting Author: Damien Boorman
Submitting Author: Damien Boorman

Description:

Chronic pain emerges in only a subset of individuals following comparable injury, yet the neural basis of this divergence remains unclear. Most preclinical studies emphasize group means and reflexive sensory assays, overlooking multidimensional behavioural outcomes and inter-individual variability. We hypothesized that chronic pain vulnerability represents a multidimensional phenotype encompassing sensory hypersensitivity, naturalistic behavioural disruption, and social dysfunction, supported by distributed supraspinal circuits. Using a neuropathic pain model, we combined whole-brain activity mapping with high-resolution behavioural phenotyping to identify brain-wide predictors of pain susceptibility and to determine how sensory and affective-social dimensions of chronic pain are correlated.

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Impact of chronic pain on negative affective state during nicotine withdrawal in male rats

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Deniz Bagdas
Presenting Author: Deniz Bagdas
Submitting Author: Deniz Bagdas

Description:

Chronic pain is a major public health problem worldwide and it is often associated with negative affect (1-3). Nicotine use is also a widespread global health problem, and nicotine withdrawal induces negative affect (4). However, it remains unclear how chronic pain influences negative affect during nicotine withdrawal. In this study, we aimed to examine affective behaviors in male rats during nicotine withdrawal in the presence or absence of chronic pain.

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CB13-mediated peripheral cannabinoid receptor activation attenuates frostbite-induced chronic pain.

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr. Vinod Tiwari
Presenting Author: Dr. Vinod Tiwari
Submitting Author: Vinod Tiwari

Description:

Frostbite-associated chronic pain is a severe and persistent complication of cold injury, characterized by long-lasting mechanical and cold hypersensitivity particularly among military personnel driven by sustained neuroimmune and excitatory signaling. Current therapeutic options remain largely symptomatic and fail to target underlying pathophysiological mechanisms. Emerging evidence highlights peripheral cannabinoid receptors as critical regulators of nociceptive transmission, inflammatory cascades, and neuronal sensitization. This study investigated the therapeutic potential of CB13, a peripherally restricted CB1/CB2 receptor agonist, in mitigating frostbite-induced chronic pain, aiming to establish peripheral cannabinoid receptor activation as a novel, mechanism-based, non-central analgesic strategy

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The study of the effect of ozone on the metabolic state of rat spinal cord neurons

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: no
Presenting Author: Tao Sun
Submitting Author: Zhijian Fu

Description:

Metabonomics analysis was used to detect the changes of the metabolic status of primary spinal cord nerve cells after medical ozone treatment, and to verify the differential expression of a series of metabolic molecules in primary spinal cord nerve cells caused by ozone.The possible molecular mechanisms and pathways of neurotoxicity of medical ozone were studied by means of information biology analysis and statistical methods.

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Intranasal oxytocin mRNA-LNP can promote social behaviour and reduce pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Greg Neely
Presenting Author: Lipin Loo
Submitting Author: Lipin Loo

Description:

The COVID-19 epidemic and success of mRNA-LNP vaccines demonstrated the transformative potential of mRNA therapeutics. Beyond vaccination, mRNA delivery offers a platform for transient on-demand expression of therapeutic proteins for both rare and common diseases. While delivery of therapeutics to the liver is relatively straightforward, targeted delivery of mRNA-LNPs to the central nervous system (CNS) remains a significant challenge.

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Eriocitrin modulates neuropathic pain response in chronic constriction injury induced mononeuropathy

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: HUANG zhangxiang
Presenting Author: HUANG zhangxiang
Submitting Author: zhangxiang huang

Description:

Neuropathic pain remains challenging to treat because of its complex mechanisms and variable responses to current therapies. Naturally occurring flavonoids have emerged as promising candidates due to their multi-target actions on pain pathways. This study evaluated the analgesic potential of eriocitrin, a flavonoid derived from Citrus limon

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Efficacy and Safety of Orally Active ?2?-1 C-Terminal Peptides in Neuropathic Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Shao-Rui Chen
Presenting Author: Hui-Lin Pan
Submitting Author: Hui-Lin Pan

Description:

Treatment for chronic neuropathic pain remains a major therapeutic challenge. Gabapentinoids (gabapentin and pregabalin) are commonly used as first-line therapy for neuropathic pain and primarily target α2δ-1, which interacts with NMDA and AMPA receptors. However, their clinical efficacy is often insufficient for many patients. Also, α2δ-1 may interact with many proteins via its N-terminal VWA domain. Moreover, the use of gabapentinoids is limited by adverse effects such as gait disturbances and ataxia, which are mediated through α2δ-2. To overcome these limitations, we have developed chemically modified α2δ-1 C-terminal peptides that retain the biological activity and are suitable for oral administration.

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Spatial Transcriptomic Insights: Astrocyte Reactivity in a Rat Model of Trigeminal Neuropathic Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Kevin A Keay
Presenting Author: James WM Kang
Submitting Author: James Kang

Description:

Chronic trigeminal neuropathic pain is particularly distressing and disabling, with current treatments largely ineffective. Part of the difficulty in treating trigeminal neuropathic pain is a consequence of the lasting functional changes within brain regions involved in pain processing. At the cellular level, the transcriptional changes in trigeminal recipient brainstem nuclei are largely unknown. Here we use spatial transcriptomic approaches to investigate the cellular and molecular changes in the medullary dorsal horn of the spinal trigeminal nucleus (SpVN) that may underpin the development and maintenance of trigeminal neuropathic pain.

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The Opposing Roles of ASIC3 in Distinct DRG neurons After Peripheral Nerve Injury

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Wei-Hsin Sun
Presenting Author: Jia-Yun Hsu
Submitting Author: Jia-Yun Hsu

Description:

Chronic constriction injury (CCI) triggers neuronal hyperexcitability via ion channel remodeling. TTX-S Na+ currents increase immediately in small-diameter DRG neurons at week 2; however, the specific Nav channels that dominate during chronic phase remain unknown. TTX-R Na+ currents exhibit broader action potentials, facilitating calcium influx and suggesting sustained signaling transduction. ASIC3 is a Na+-permeable ion channel that is expressed abundantly in large-diameter DRG neurons. We previously revealed that ASIC3 deletion relieves CCI-induced mechanical allodynia from week 8 (chronic phase). Therefore, I wonder (1) which Nav channels mediate chronic phase and (2) whether ASIC3 regulates Nav channels to relieve chronic pain.

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Sex-dependent Analgesia by MIF Inhibition: ISO-1 Reduces Neuropathic Pain after Sciatic Nerve Injury

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Jiri Palecek MD, PhD
Presenting Author: Jiri Palecek MD, PhD
Submitting Author: Jiri Palecek

Description:

Peripheral neuropathic pain markedly impairs quality of life and remains challenging to treat. After peripheral nerve injury, coordinated peripheral and central processes drive persistent hypersensitivity, shaped by bidirectional signaling between immune cells and nociceptive pathways. Macrophage migration inhibitory factor (MIF), a pleiotropic pro-inflammatory cytokine, has emerged as a contributor to these neuroimmune cascades. We investigated whether pharmacological MIF antagonism with ISO-1 modifies neuropathic pain in adult mice using chronic constriction injury (CCI) of the sciatic nerve. Outcomes were evaluated in both males and females to address potential sex-dependent differences.

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Investigating Placental Transcriptomic Adaptations to Maternal Neuropathic Pain During Pregnancy

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Loren Martin
Presenting Author: Julia Schneider Krimberg
Submitting Author: Julia Schneider Krimberg

Description:

Chronic pain is highly prevalent during pregnancy yet remains under-treated due to limited pharmacological options and concerns about fetal exposure. As a result, many individuals experience persistent pain throughout gestation, but its biological impact on the maternal-fetal interaction is poorly understood. The placenta regulates fetal exposure to maternal signals, including nutrients, hormones, and immune mediators, and its function is shaped by maternal physiological state. Unlike other maternal stressors, pain may represent a distinct condition with unique effects on placental function and integrity. We therefore aimed to determine how gestational neuropathic pain affects fetal development and placental gene expression, with the goal of identifying molecular adaptations at the maternal-fetal interface.

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Sex-Specific Role of CB2 in Exercise Protection Against Chemotherapy-Induced Neuropathy

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Andrea G Hohmann
Presenting Author: Laura Boullon
Submitting Author: Laura Boullon

Description:

Chemotherapy-induced peripheral neuropathy (CIPN) and cognitive dysfunction are debilitating side effects of paclitaxel treatment that severely impact the quality of life in cancer patients. While voluntary exercise is a promising non-pharmacological strategy to alleviate these symptoms, the underlying neurobiological mechanisms and the specific role of the endocannabinoid system remain poorly understood. This study investigated the contribution of cannabinoid receptor 2 (CB2) to the beneficial effects of exercise on paclitaxel-induced mechanical hypersensitivity and cognitive deficits.

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Neuregulin-4 From Brown Adipose Tissue Preserves Sensory Innervation in Diabetes

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Stanley Wong Sau Ching
Presenting Author: Liao Boya
Submitting Author: Boya Liao

Description:

Diabetic peripheral neuropathy (DPN) particularly the distal symmetric painful form, is a common debilitating complication of diabetes that causes burning and shooting pain, numbness and disability. Current treatments are largely symptomatic, often ineffective and limited by side effects, underscoring the need for disease-modifying approaches that preserve peripheral nerve integrity. Neuregulin-4 (NRG4) is enriched in brown adipose tissue (BAT) and exerts trophic, anti-inflammatory actions. We hypothesis that BAT-derived NRG4 preserves intra-BAT afferents and dorsal root ganglion (DRG) neurons via ErbB4/PI3K/PIP₃ signaling, and whether loss of this trophic axis in diabetes drives sensory degeneration and pain.

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Coding Properties of Spinal Projection Neurons in Awake, Behaving Mice Before and After Nerve Injury

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Allan Basbaum
Presenting Author: Mariela Rosa Casillas
Submitting Author: Mariela Rosa Casillas

Description:

In acute and chronic neuropathic pain settings, spinal cord dorsal horn projection neurons (SCPNs) are key conduits of peripheral and central sensitization, transmitting nociceptive signals to the brain, to generate pain percepts. Here, by monitoring the activity of SCPNs, before and after chronic pain develops, in awake, behaving mice, we address mechanisms underlying the transition from acute to chronic pain. Our studies expand on previous reports characterizing Phox2a neuron coding properties in naïve states (Zhang et al, 2026) and in anesthetized preparations following nerve injury (Yarmolinsky et al, 2025).

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Sphinganin- and Sphingosing-1-Phosphat Receptors in Chemotherapy Induced Peripheral Neuropathy

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Prof. Dr. Marco Sisignano
Presenting Author: Max Bromberger
Submitting Author: Max Bromberger

Description:

Chemotherapy induced peripheral neuropathy (CIPN) is a common dose limiting toxicity of many first line anticancer drugs, especially occurring under therapy with platinum compounds, taxanes, vinca alkaloids, and bortezomib. Clinically, CIPN mainly occurs as a chronic sensory neuropathy with numbness, tingling, hypersensitivity as well as neuropathic pain which can persist for months to years after treatment and markedly impair quality of life. Even considerable efforts to develop a suitable therapy have not yet led to success and duloxetine is currently the only pharmacological option with moderate evidence, while no established preventive therapy exists. Here we show dysregulated sphingolipid and sphingosine 1 phosphate (S1P) receptor signaling as possible cause in CIPN, particularly in models of platinum induced peripheral neuropathy.

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Time-Dependent Characterization of Orofacial Pain in STZ-Induced Diabetic Rats via Operant Assay

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Milena Barbosa Costa
Presenting Author: Milena Barbosa Costa
Submitting Author: Milena Barbosa Costa

Description:

Diabetic neuropathy is a prevalent and disabling complication of type 1 diabetes, causing chronic pain and diminished quality of life despite glycemic control. It can impair trigeminal nerve function, disrupting orofacial sensory processing and pain perception. Rodent models of streptozotocin (STZ)-induced diabetes demonstrate hyperalgesia across multiple regions, including the orofacial area, yet the mechanisms underlying trigeminal dysfunction remain unclear. This study investigated time-dependent patterns of diabetic neuropathic pain in male Wistar Hannover rats, focusing on orofacial outcomes. The trigeminal inflammatory profile was assessed to provide mechanistic insight and support the development of more effective clinical strategies for managing diabetic neuropathy.

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Electroacupuncture alleviates central post stroke pain by modulating miR-21-5p/ TGF-β/Smads pathway

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Zhihao Shang
Presenting Author: None
Submitting Author: Zhihao Shang

Description:

Background Central post-stroke pain (CPSP) poses a persistent challenge with limited responses to current
pharmacological interventions. Recent evidence implicates miR-21 and its downstream TGF-β/Smads signaling
pathway in pain pathophysiology. This study investigates whether the analgesic effect of electroacupuncture (EA) is
related to miR-21/TGF-β/Smads signaling pathway in CPSP.

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Targeting neuroplasticity in chronic neuropathic pain with novel small molecules

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Peter Penzes
Presenting Author: Peter Penzes
Submitting Author: Peter Penzes

Description:

Background and Aims
Neuropathic pain (NP) affects ~10% of the population; current standards of care provide adequate relief in fewer than half of patients and carry significant side-effect liabilities. No approved therapeutic targets the etiological CNS mechanisms underlying NP. Maladaptive dendritic spine remodeling in spinal dorsal horn neurons, driven by Rac GTPase signaling downstream of guanine nucleotide exchange factors (GEFs), is a central pathophysiological mechanism. Pharmacological Rac inhibition and Tiam1 GEF ablation produce long-lasting preclinical analgesia, validating this pathway. However, Rac’s ubiquitous expression necessitates tissue-selective upstream targeting. Kalirin is a CNS-enriched Rac-GEF concentrated at postsynaptic densities, upregulated in spinal neurons following nerve injury, and required for central sensitization — making it an ideal node for spatially restricted Rac inhibition. We aimed to identify first-in-class kalirin GEF inhibitors, characterize their neuronal activity and analgesic efficacy, and evaluate human genetic support for this pathway in chronic pain.​​​​​​​​​​​​​​​​

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Novel Short Lipidated Peptidomimetic Targeting Nav1.8 Reduces Neuropathic Pain-like Behaviors

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Rasheen Powell
Presenting Author: Rasheen Powell
Submitting Author: Rasheen Powell

Description:

Neuropathic pain remains a major therapeutic challenge, with over 50% of patients responding inadequately to existing therapies (gabapentinoids, SNRIs, TCAs). Dorsal root ganglion (DRG) neurons serve as primary sites for injury-induced plasticity underlying painful peripheral pathophysiologies. Voltage-gated sodium channels (VGSC), specifically Nav1.8, are highly expressed in DRGs and are critical for nociception. Recently, suzetrigine, a Nav1.8-specifc blocker, received FDA approval for acute pain, validating Nav1.8 as a viable clinical target for pain. However, targeting Nav1.8 for neuropathic pain remains unclear. Therefore we aimed to develop a non-opioid analgesic targeting Nav1.8 for the treatment of chronic neuropathies.

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Lipid-lowering Drugs and Neuropathic Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Zongbin Jiang
Presenting Author: Ruilin He
Submitting Author: RUILIN HE

Description:

Neuropathic pain (NP), characterized by somatosensory nervous system dysfunction, manifests as diabetic peripheral neuropathy (DPN), postherpetic neuralgia (PHN), and trigeminal neuralgia (TN). Emerging evidence suggests a potential link between dyslipidemia and NP pathogenesis. However, the neurological effects of statins, PCSK9 inhibitors, and NPC1L1 inhibitors remain controversial. This study investigates the causal relationships between these lipid-lowering agents and NP subtypes, providing evidence for personalized therapeutic strategies.

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The Effect of Combination Therapy with Gabapentinoid and Goshajinkigan in a Rat Model of CIPN

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Yasuhito Uezono
Presenting Author: Saeko Hamaoka
Submitting Author: Saeko Hamaoka

Description:

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting complication of neurotoxic anticancer drugs. CIPN dominantly presents with sensory disturbances such as pain and numbness, which markedly impair daily functioning and quality of life and often necessitate dose reduction or discontinuation of chemotherapy. Despite its clinical impact, no established therapy effectively prevents or treats CIPN. A retrospective cohort study suggested that combination therapy with a gabapentinoid (GPN) and the Japanese Kampo medicine goshajinkigan (GJG) may improve CIPN symptoms. Therefore, we investigated its therapeutic potential using a rat model of CIPN.

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A neuronal mechanism underlying comorbid pain and depression in mice

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Feng Tao
Presenting Author: Sufang Liu
Submitting Author: Sufang Liu

Description:

Trigeminal neuropathic pain is a chronic, debilitating condition often accompanied by depressive symptoms; however, the mechanisms behind this comorbidity remain poorly understood. Here, we aimed to identify and test the function of injury-activated neurons in the parasubthalamic nucleus (PSTN) that modulate both pain and depression-like behaviors in a trigeminal neuropathic pain model.

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GDF5 Activates Smad1/5/8-Akt Signaling to Attenuate Trigeminal Neuralgia-Related Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Hui Li
Presenting Author: Tao Liu
Submitting Author: Tao Liu

Description:

Growth differentiation factor 5 (GDF5), a prominent member of the bone morphogenetic protein family, has demonstrated significant potential in promoting neural repair and maintaining myelin integrity. However, its therapeutic relevance in trigeminal neuralgia (TN) remains largely unexplored. This study investigated whether GDF5 exerts protective effects against demyelination and mechanical hypersensitivity in a rat model of TN, alongside its underlying molecular mechanisms.

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Therapeutic Investigation of Amantadine in Burn-Induced Chronic Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr Vinod Tiwari
Presenting Author: Vaibhav Thakur
Submitting Author: Vaibhav Thakur

Description:

This study aimed to explore the therapeutic potential of amantadine in alleviating chronic pain caused by burn injuries (BI) in a rat model. It focused on key pain mechanisms, oxidative stress, and CNS safety to evaluate its efficacy and safety profile.

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Mechanism of Medial Ventral Tegmental Area to the Lateral Habenula in Chronic Pain Comorbidity

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Wangyuan Zou
Presenting Author: Wangyuan Zou
Submitting Author: Wangyuan Zou

Description:

The mechanisms underlying chronic pain comorbid with anxiety and depression remain elusive, posing substantial clinical challenges. This study aims to investigate the role of ventral tegmental area (VTA) glutamate (Glu)/GABA co-releasing neurons and their projections to the lateral habenula (LHb) in the pathogenesis of chronic pain–anxiety/depression comorbidity, and to provide a theoretical basis for developing synergistic intervention strategies.

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TREM1 enhance spinal M1 microglia polarization and mitochondrial dysfunction in neuropathic pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: xuebi tian
Presenting Author: xiaoyu zhang
Submitting Author: xiaoyu zhang

Description:

Objective: The activation of the triggering receptor expressed on myeloid cells 1 (TREM1) potentiates innate immunity by triggering the induction of pro-inflammatory mediators from neutrophils and monocytes. We previously showed that TREM1 fuels chronic neuropathic pain (NP), yet the downstream mechanisms remain unclear. Here, we aimed to investigate whether TREM1 triggers NP by skewing microglial toward the M1 phenotype and suppressing neuronal AMPK/PGC-1α signaling, thereby impairing mitochondrial function.

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The Alteration of Proprioception & Its Roles of Modulation in Painful Diabetic Neuropathy

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Chih-Cheng Chen
Presenting Author: Yi-Chen Lin
Submitting Author: Yi-Chen Lin

Description:

Effective treatments for neuropathic pain remain an unmet medical need in diabetic neuropathy. However, the mechanisms in peripheral sensitization of painful diabetic neuropathy are largely unclear. According to previous research, the characteristics of rate-dependent depression of the Hoffmann reflex involved in proprioceptive function are good biomarkers for painful diabetic neuropathy in both animal and human studies[1-2]. Deletion of proprioceptive (parvalbumin-positive) neurons in DRG leads to enhanced nociceptor activity and increases acute thermal and mechanical pain behaviors[3].
Aims: to identify what are the roles of proprioceptors in PDN and to assess proprioceptor morphological change or degeneration after diabetic induction

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Preclinical Behavioural Investigation of Nucleus Accumbens Modulation in Chronic Neuropathic Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Michael T Bowen
Presenting Author: Yiyang Wang
Submitting Author: Yiyang Wang

Description:

Chronic neuropathic pain is associated with maladaptive changes in central pain circuitry, yet current treatments remain limited with side effects. The nucleus accumbens (NAc) shell has been increasingly implicated in chronic pain processing, but its key role in modulating pain-related behaviour remains unclear. KNX100 is a novel small molecule compound developed by Kinoxis Therapeutics that modulate NAc shell activity and is therefore promising in targeting pain circuitry. This study aimed to investigate whether pharmacological modulation of NAc shell activity alters behavioural hypersensitivity in a rat model of chronic neuropathic pain.

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KNX Compounds Reduce Thermal Hypersensitivity in Chronic Neuropathic Pain: A Preclinical Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Michael Bowen
Presenting Author: Zeynab Alshelh
Submitting Author: Zeynab Alshelh

Description:

Chronic neuropathic pain is maintained by dysregulated central circuits and neuronal hyperexcitability that remain inadequately targeted by current therapies[1,2]. KNX100 is a novel non-opioid compound targetting nucleus accumbens, which is recognised as modulators of central pain processing[3 ,4]; KNX101 is an analogue designed for longer duration and enhanced efficacy. This study tested whether these compounds could treat established neuropathic pain in the chronic constriction injury (CCI) model. We aimed to (1) characterise thermal hypersensitivity, (2) determine whether repeated KNX dosing reduces hind paw withdrawals compared with vehicle and gabapentin, and (3) assess whether any effects persist after washout.

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Disruption of the Trigeminal Myelin Transition Zone After Infraorbital Nerve Constriction Injury

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Kevin Keay
Presenting Author: Dylan Lugt
Submitting Author: Dylan Lugt

Description:

Chronic trigeminal neuropathic pain (CTNP) is a debilitating condition with limited effective treatment options, partly due to an incomplete understanding of the early cellular mechanisms that support the transition from acute to chronic pain1,2. This study aimed to investigate neuroglial adaptations within the central-peripheral myelin transition zone (TZ) of the trigeminal nerve (Vn) following infraorbital nerve chronic constriction injury (ION-CCI) 3,4. Using the immunohistochemical detection of glial fibrillary acidic protein (GFAP); monoamine oxidase-B (MAO-B); connexin-43 (Cx43) and aquaporin-4 (AQP4) we sought to characterise changes in astrocyte reactivity at the TZ in male and female rats, over a 28-days post-injury period.

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Early Melittin and Apitoxin Acupuncture as an Analgesic Intervention for Neuropathic Pain in Females

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Gisele Picolo
Presenting Author: Mariana Gianfrancesco Rodrigues Leonor
Submitting Author: Mariana Leonor

Description:

Neuropathic pain is one of the most prevalent chronic pain, affecting approximately 8% of the global population, with women representing 60% of neuropathic pain cases. Sex-related differences in pain sensibility and analgesic efficacy of drugs are reported. However, basic searches, pre-clinical assays, and clinical trials are still mostly conducted in males. This accounts for the poor understanding of the painful mechanism, hormonal influence, and the effectiveness of new compounds in females. Considering that the treatment of chronic pain remains a challenge, mainly for women, we currently focus on delaying its establishment and the pain onset using apitoxin and melittin.

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Immune-Mediated Mechanisms Underlying SARS-CoV-2 Spike�Induced Persistent Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Robson da Costa
Presenting Author: Robson da Costa
Submitting Author: Robson da Costa

Description:

Persistent pain is a frequent and disabling feature of post-COVID-19 syndrome, yet its biological mechanisms remain poorly understood. Beyond viral replication, SARS-CoV-2 structural proteins can act as immunogenic triggers capable of inducing long-lasting neuroimmune alterations. While the Spike protein has been implicated in transient nociceptive effects, its role in sustained pain processing is unclear. Here, we investigated whether peripheral exposure to the SARS-CoV-2 Spike protein is sufficient to induce persistent pain-like behaviours and sought to identify the immune pathways and mediators underlying these sensory alterations.

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Biosensor-based classification of chronic post-surgical pain using serum responses.

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dusan Matusica
Presenting Author: Benjamin R Hoy
Submitting Author: Benjamin Hoy

Description:

Chronic post-surgical pain (CPSP) remains difficult to identify objectively, as current assessment relies largely on behavioural and subjective measures that provide limited insight into the underlying biology (Fuller et al., 2023; Mackey et al., 2025). Circulating serum factors may reflect pathological processes associated with chronic pain and could therefore be exploited in functional biosensor systems (Gerdle & Ghafouri, 2020; Mackey et al., 2025). We investigated whether the nociceptor-like 50B11 cell line could detect and classify serum-associated signatures of CPSP across longitudinal stages following surgical injury, supported by complementary molecular profiling (Matusica et al., 2021).

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Ginsenoside Rd Attenuates Spinal Cord Surgery Injury via the ROS/TXNIP/NLRP3 Inflammasome Axis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Min Yao
Presenting Author: Jia-xuan Zhang
Submitting Author: 张 嘉轩

Description:

Surgical decompression for degenerative cervical myelopathy can induce spinal cord ischemia-reperfusion injury, contributing to postoperative neuroinflammation, neuronal injury, and chronic pain-like functional impairment. This process is driven by oxidative/ER stress and subsequent NLRP3 inflammasome activation via the ROS/TXNIP axis, a pathway strongly associated with central sensitization and neuropathic pain. Ginsenoside Rd (Rd), a natural compound with anti-inflammatory potential, was investigated for its capacity to attenuate surgery-induced neuroinflammation, reduce behavioral hypersensitivity, and enhance functional recovery by targeting the ROS/TXNIP/NLRP3 signaling in a rat model of cervical spinal cord decompression.

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Persistent changes in spinal cord projection neuron activity after hindpaw incision

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Allan I. Basbaum
Presenting Author: Tia A. Tummino
Submitting Author: Tia Tummino

Description:

Although peripheral injury produces robust behavioral hypersensitivity that often resolves, clinical and preclinical evidence suggests that long-lasting changes in pain-generating circuits may persist, contribute to, and exacerbate future pain episodes[1–3]. Most interestingly, the behavioral manifestation of pain following injury recovery can be reestablished by injection of opioid antagonists[4,5], suggesting a latent sensitization process that may affect the long-term activity of dorsal horn pain processing circuits. Here, in awake behaving mice, we longitudinally track the activity of spinal cord projection neurons before, during, and after injury recovery, and test whether opioid receptor blockade unmasks persistent injury-induced neuronal hyperexcitability.

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Reduced TET1 in the DRG and spinal cord is necessary for sleep disturbance to prolong surgical pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Yuan-Xiang Tao
Presenting Author: Yuan-Xiang Tao
Submitting Author: Yuan-Xiang Tao

Description:

Sleep disturbance delays surgical pain recovery. This impact is associated with the dysregulation of gene expression in the dorsal root ganglion (DRG) and spinal dorsal horn (SDH). However, the mechanisms underlying this dysregulation remain unclear.

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Dulaglutide Attenuates Chronic Migraine�Like Pain in Both Sexes: Toward Novel Preventive Strategies

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Ana Micov
Presenting Author: Ana Micov
Submitting Author: Ana Micov

Description:

Chronic migraine (CM) is a highly disabling condition disproportionately affecting young women (1). Migraine frequently coexists with obesity, insulin resistance, and diabetes, which may increase disease burden (2). Agents with dual antinociceptive and metabolic properties represent a rational therapeutic avenue for CM. Liraglutide, a glucagon-like peptide-1 receptor agonist widely used in the treatment of type 2 diabetes and obesity, has recently demonstrated efficacy in CM in preclinical and clinical settings (3,4). We evaluated the antinociceptive efficacy and metabolic safety of dulaglutide compared with propranolol (reference drug) following repeated prophylactic administration in a nitroglycerin (NTG)-induced CM model in both sexes.

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Sex-stratified genome-wide association analysis finds a novel female-specific migraine locus in CAP2

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Ian R. Gizer
Presenting Author: Matthew Seebald
Submitting Author: Matthew Seebald

Description:

Migraine is a debilitating, chronic disease that disproportionately affects females, with prevalence three to four times higher than in males. While the genetic architecture of migraine has been explored extensively, few studies have investigated whether sex-dependent genetic effects contribute to this disparity. We therefore sought to characterize differences in the genetic architecture of migraine between females and males using genome-wide association study (GWAS) approaches, and to identify alleles that may contribute to sex differences in migraine phenotypes.

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Behavioural Characterisation of a Novel Rodent Model of Supraorbital Head Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Kevin A Keay
Presenting Author: Olivia I Davanzo
Submitting Author: Olivia Davanzo

Description:

Chronic head pain, including chronic migraine and cluster headaches, are debilitating and relentless for sufferers. The precise mechanisms underlying these conditions are still poorly understood, hindering the development of specific and effective treatments. Preclinical animal models are crucial in defining the circuitry of sensory sensitivity and emotional disturbances characteristic of these conditions. Pain with a supraorbital distribution is frequent in human clinical presentations, thus, we developed a rodent model of chronic head pain by manipulating the supraorbital nerve (SoN), a branch of the ophthalmic division of the trigeminal nerve that plays a critical role in transmitting head pain signals.

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Astrocytic S1PR1 Role in S1PR1 Antagonist Mechanism in Comorbid Migraine/Temporomandibular Disorders

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr. Daniela Salvemini
Presenting Author: Spencer Jones
Submitting Author: Spencer Jones

Description:

Migraine is one of the leading causes of disability, affecting 40 million people in the US alone[1, 2]. Overlapping pain conditions greatly exacerbate patients’ experience, exemplified by over 40 percent of Temporomandibular Disorder (TMD) patients who report migraine symptoms that elicit higher levels of pain and disability[3-8]. The mechanistic underpinnings of this connection remain unknown. We have previously shown that sphingosine-1-phosphate receptor subtype 1 (S1PR1) activation contributes to the development of chronic pain conditions[9-12]. Furthermore, our lab has identified astrocytes as the primary cellular substrate for S1PR1 activity[9, 11]. However, the role of astrocytic S1PR1 in TMD-migraine comorbidity is unknown.

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Immune Profiling in Trigeminal Neuralgia: Altered Cytokine/Chemokine Signatures in CSF But Not Serum

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: tong liu
Presenting Author: ziwei liu
Submitting Author: ziwei liu

Description:

Trigeminal neuralgia (TN) is a debilitating neuropathic pain disorder traditionally attributed to neurovascular compression; however, this mechanism does not fully explain its clinical heterogeneity or persistent pain in a subset of patients. Increasing evidence implicates central neuroinflammatory processes in neuropathic pain, yet immune profiles in the cerebrospinal fluid (CSF) and serum of patients with TN remain poorly characterized. This exploratory study aimed to identify potential neuroimmune biomarkers by comparing CSF and serum immune mediator profiles in patients with TN.

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Activation of Pain-Related Brain Regions in a Nonhuman Primate Model of Knee Osteoarthritis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Mark Varney
Presenting Author: Aldric Hama
Submitting Author: Aldric Hama

Description:

Complete understanding of association between in vivo brain functioning and chronic pain has yet to be fully elucidated. Uncovering the association between brain functioning and pain could lead to utilization of brain functioning as a marker for pain, an individual and subjective experience. Complicating clinical understanding of the association between brain functioning and pain is the use of a preclinical species that is phylogenetically distant from humans. The goal of the current study is to identify brain activation in response to peripheral stimulation in cynomolgus macaques with a unilateral knee osteoarthritis (OA). A secondary goal is to identify potential sex differences in brain activation, as sex differences in responses to chronic pain have been reported.

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Sex Dependent Contribution of CGRP? to Pain and Disease Processes in Mice with Knee Arthritis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Christopher M. Peters
Presenting Author: Christopher M.Peters
Submitting Author: Christopher Peters

Description:

Osteoarthritis is the most common cause of chronic pain and disability in the U.S impacting nearly 20% of the U.S. population over 45 years of age (1, 2). Knee OA is a progressive disorder characterized by persistent synovial inflammation, fibrosis, cartilage degeneration and bone structural changes leading to severe pain and disability. While OA affects both men and women, women make up approximately 60% of OA cases and have worse clinical outcomes compared to men (3). Despite this knowledge, very few preclinical studies have examined potential sexual dimorphism present in pain or cellular processes associated with the development of knee arthritis (4).

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Human Antibody Responses to Gut Bacteria in Fibromyalgia

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Emerson Krock
Presenting Author: Ezrah Isaac Roy
Submitting Author: Ezrah Isaac Roy

Description:

Fibromyalgia (FM) patients exhibit distinct gut microbiome alterations, with specific bacterial taxa correlating with pain severity. Additionally, the transfer of FM IgG into mice triggered the transfer of FM symptoms. Previously identified a role for IgG autoantibodies in FM pain. Normally a portion of gut bacteria is coated by IgA, but IgG coating of gut bacteria is rare and often signals an abnormal immune response4. It remains unclear how microbiome community changes could drive the production of painful autoantibodies in FM. Here, we investigate whether specific gut bacterial taxa exhibited altered antibody coating in FM patients compared to pain-free controls.

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Fibromyalgia gut microbiota stimulates the generation of pain-inducing IgG in mice

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Emerson Krock
Presenting Author: Hannah Cho
Submitting Author: Hannah Cho

Description:

Introduction: We previously identified a role for pain-inducing IgG autoantibodies in fibromyalgia (FM), but why these autoantibodies develop remains unclear. The gut microbiome of FM patients is altered, and the fecal microbiota transfers (FMT) of FM stool samples into germ free mice induce pain. Our hypothesis is that pain-indcuing FM autoantibodies develop through cross-reactivity with gut bacteria. Here, we will determine how the FM gut microbiome drives an adaptive immune response that leads to pain-inducing autoantibodies in mice.

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Cortical Signatures of Chronic Pain after Rotator Cuff Injury in Mice

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Jarret Weinrich
Presenting Author: Jarret Weinrich
Submitting Author: Jarret Weinrich

Description:

Rotator cuff injury (RCI) is a leading cause of chronic musculoskeletal pain, yet current therapies
remain limited. Surgical repair provides modest benefit, and pharmacologic options such as NSAIDs and
opioids rarely offer durable relief. Because pain is ultimately encoded in the brain, we hypothesized that
persistent pain after RCI reflects altered cortical processing. We focused on the anterior cingulate cortex
(ACC), a region critical for the affective dimension of pain, and sought to link RCI-induced behavioral deficits
with ACC activity.

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Characterisation of CHRNA3 Cre-ERT2 mouse line

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: George Goodwin
Presenting Author: Łukasz Pietras
Submitting Author: George Goodwin

Description:

CHRNA3 is a molecular marker of a population of silent nociceptors that innervate deep tissue such as joint and muscle [1], as well as sympathetic neurons. Using CRISPR-Cas9 gene editing, we have generated a knock-in CHRNA3 Cre ERT2 mouse with the aim to study silent nociceptors in the context of musculoskeletal and cancer pain. In this study we have used Cre dependent viruses and reporter lines to characterise the level of Cre-ERT2 recombination in sensory and sympathetic neurons in perinatal, adolescent and adult mice following tamoxifen administration.

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Self-Management Practice, Barriers, and Facilitators in People Living with Chronic Pain in Ethiopia

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Bruno T Saragiotto
Presenting Author: Moges Gashaw
Submitting Author: Moges Gahaw

Description:

Self-management (SM) is a key component of chronic pain care, requiring individuals to play active roles in managing their pain[1]. Cultural beliefs and perceptions towards pain strongly shape health-seeking behaviour[2]. Effective SM interventions depend on patients’ ability to modify unhealthy behaviours and adopt healthier ones. Therefore, assessing patients’ experiences, knowledge, skills, and confidence in managing their conditions is essential. Understanding barriers and enablers within behavioural change frameworks is also crucial for designing effective SM programs. This study aimed to explore the patient experiences, barriers, and facilitators of SM among Ethiopian individuals with chronic pain using the Theoretical Domains Framework (TDF)[3].

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Widespread gray matter volume reduction in pediatric MSK pain associates with pain catastrophizing

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Massieh Moayedi
Presenting Author: Spencer S. Abssy
Submitting Author: Spencer Abssy

Description:

Pediatric chronic MSK pain adversely affects quality of life(1). Pain catastrophizing is associated with pain morbidity, emotional distress, and treatment outcomes in this population(2). Therefore, some pain management strategies target pain catastrophizing(3). However, the structural neural underpinnings of pain catastrophizing remain poorly understood, and identifying these could provide therapeutic neural targets(4,5). Here, we identify the neural correlates of pain catastrophizing in adolescents with chronic MSK pain, compared to pain-free controls to assess specificity. We hypothesized that lower gray matter volume in regions associated with pain catastrophizing would correlate with higher catastrophizing scores in patients but not controls.

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Blocking Nerve Growth Factor Attenuates Nociceptive Behaviors in A Mouse Model of Fibrous Dysplasia

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Anne-Marie Heegaard
Presenting Author: Yingyu Tang
Submitting Author: Yingyu Tang

Description:

Fibrous dysplasia (FD) is a rare bone disease in which bone tissue is replaced by a woven fibro-osseus tissue, the pathological mechanism of which is somatic gain-of-function GNAS mutation1. Many patients with FD experience pain and identify pain relief as a high research priority2,3. Previous work4 has suggested that pain-related pro-inflammatory cytokines and growth factors, including nerve growth factor (NGF), are unregulated in FD. Therefore, the aim of this study is to identify the effects of the anti-NGF antibody tanezumab on pain-like behaviors in a mouse model of FD.

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Exploring serotonin, melatonin and cortisol as biomarkers for chronic musculoskeletal pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Linzette D. Morris
Presenting Author: Linzette D. Morris
Submitting Author: Linzette Morris

Description:

Chronic musculoskeletal pain (CMP) is a complex condition, generally measured by subjective measures. Recent advances have been made in understanding CMP on a biophysiological level. It is becoming evident that understanding biomarkers i.e. serotonin, melatonin, and cortisol in CMP can provide an objective way in which to better understand the biological factors which affect CMP. However little remains known about this topic. The aim of the study was preliminarily explore the relationship between the biomarker concentration levels (i.e., serotonin, melatonin, and cortisol), and self-reported musculoskeletal pain, sleep quality and mood in a population of undergraduate students with/without pain in Qatar.

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Combining human and mouse models to dissect the role of neurovascular interactions in arthritis pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Franziska Denk
Presenting Author: Irene Zebochin
Submitting Author: Irene Zebochin

Description:

Current therapies against rheumatoid arthritis (RA) effectively reduce inflammation. However, in many individuals, this does not translate into reduction or resolution of joint pain. Pathological neovascularization has long been a target of interest for RA treatment. Changes in vascular structure persist beyond the classical inflammatory response, and these altered neurovascular interactions may contribute to driving persistent joint pain. Following evidence that pericytes are involved in pain in a nerve injury model[1], we aim to determine whether joint vascular changes contribute to long lasting neuronal sensitization and pain in RA.

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ENDOCANNABINOID SYSTEM ATTENUATES EMOTIONAL STRESS-INDUCED OROFACIAL MUSCULOSKELETAL PAIN IN RATS

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Mariana Lima Vale
Presenting Author: Mariana Lima Vale
Submitting Author: Bruno Freitas-Alves

Description:

Orofacial musculoskeletal pain (OMP) affects individuals with temporomandibular disorders (TMD), a group of conditions affecting temporomandibular joint, chewing muscles and associated structures. A biopsychosocial model of pain is now recognized in the etiology of muscular TMD, highlighting the complexity related to OMP. Painful TMD is typically chronic, bilateral, diffuse, and associated with jaw movement, aligning with the criterion for nociplastic pain addressed by Kosek et al. (2021). In this sense, the objective is to study the OMP induced by psychological/emotional stress (ES) in rats, regarding the role of the endocannabinoid system (ECS) through CB1 and CB2 receptors.

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Involvement of the trigeminal spinal subnucleus oralis in orofacial neuropathic pain development

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Koichi Iwata
Presenting Author: Koichi Iwata
Submitting Author: Koichi Iwata

Description:

Recent studies have shown that a significant number of nociceptive neurons are located in the trigeminal spinal subnucleus oralis (Vo), suggesting that the Vo functions as a orofacial pain perception. We hypothesized that Vo noceptive neurons contribute to the development of persistent orofacial pain following trigeminal nerve injury. However, the contribution of these neurons projecting from the trigeminal ganglion (TG) to the Vo (TG-Vo neurons) to persistent orofacial pain remains unclear. Therefore, we investigated the role of the TG–Vo pathway in the development of orofacial neuropathic pain using a rat model of partial infraorbital nerve ligation (PNL).

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Capture of analgesic-responsive facial pain of unrestrained mice in a trigeminal neuralgia model

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Xiaobing Yu
Presenting Author: Xiaobing Yu
Submitting Author: Xiaobing Yu

Description:

Trigeminal neuralgia (TN) is a devastating neuropathic pain condition that profoundly impacts human well-being, physically and psychologically. Despite an initial response to carbamazepine (CBZ), many patients become refractory to pharmacotherapy and subsequent invasive procedures. Although preclinical trigeminal neuropathic pain models following extracranial chronic constriction injury (CCI) of the trigeminal nerve have been developed, the injury-induced facial hypersensitivity is rarely CBZ responsive, questioning the models’ relevance to TN. Notably, recent reports reveal that facial pain induced by intracranial CCI of the trigeminal nerve is CBZ responsive and thus better mimics the compression observed in classical TN.

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Interoception and pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Yu Shin Kim
Presenting Author: Yu Shin Kim
Submitting Author: Yu Shin Kim

Description:

Interoception, the sense of the body's physiological condition, is mediated by vagal afferents, which are connected to major parasympathetic efferents leading to the maintenance of bodily homeostasis. Although interoceptive vagal inputs are well known to regulate pain, the neurobiological mechanisms by which vagal activity modulates chronic pain are not well understood. Increasing interoceptive inputs through electrical stimulation of the vagus nerve treats intractable chronic pain and emotional disorders, such as depression. However, vagal inputs can be also pro-nociceptive and can aggravate pathological pain. Therefore, identifying subtypes of vagal afferents responsible for anti-nociception is a critical hurdle for developing more effective and novel analgesic approaches. Temporomandibular disorder (TMD) is a prevalent cause of chronic pain, for which treatment is challenging. Temporomandibular joint (TMJ) is unique, because, unlike other joints, TMJ is directly innervated by vagal afferents.

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Rodent-Specific Behavioral Signatures and Peritoneal Immune Shifts in a Mouse Endometriosis Model

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Esther Pogatzki-Zahn
Presenting Author: Bruno Pradier
Submitting Author: Bruno Pradier

Description:

Endometriosis-related chronic pain spans sensory, affective, and functional domains, yet most rodent studies used to translate to pain in patients reduce this complexity to evoked hypersensitivity, overlooking ongoing, disability-relevant behaviors and biological correlates. We aim to characterize non-evoked pain behavior, stratify clinically-relevant endometriosis pain phenotypes across mouse models, and link these to longitudinal molecular signatures in blood and lesions to align preclinical signals with patient data and prioritize mechanisms and biomarkers. Here, we present data from one endometriosis mouse model using complementary readouts—continuous home-cage behavior, evoked mechanical sensitivity, and peritoneal immune-cell profiling—to identify stratification signals for multi-omics analyses.

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Anterior Cingulate Cortex Mu-Opioid Receptor-expressing Neurons Regulate Chronic Visceral Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Yi Dai
Presenting Author: Linqian Yu
Submitting Author: LINQIAN YU

Description:

Chronic visceral pain is a common clinical problem with complex underlying mechanisms. The anterior cingulate cortex (ACC) plays a critical role in pain processing[1]. The μ-opioid receptor (MOR) is abundantly expressed in the ACC[2] and both exogenous and endogenous opioids have been reported to modulate pain processing in the ACC[3-4], however, the function of MOR–expressing neurons within the ACC remains unclear. This study aims to investigate the role of MOR-expressing neurons in layer V of the ACC in visceral pain.

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Characterization of the anti-hyperalgesic potential of probiotics from strains of Faecalibacterium

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: PERAUT CAMILLE
Presenting Author: PERAUT CAMILLE
Submitting Author: Camille PERAUT

Description:

Faecalibacterium has emerged as a promising next-generation probiotic, attracting considerable interest due to its anti-inflammatory properties. In addition, this strain has been shown to play an important role in the regulation of colonic hypersensitivity (CHS) in a chronic stress model induced by neonatal maternal separation (NMS). Moreover, patients suffering from irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD) commonly exhibit intestinal dysbiosis, characterized by reduced microbial diversity and, in particular, a decreased abundance of Faecalibacterium genus. The present study investigates the therapeutic potential of this genus to modulate colonic sensitivity and the associated neuro-inhibitory mechanisms.

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Piezo2 Channel as a Target for Electroacupuncture in Vulvodynia: A Mouse Model Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Hua Xu
Presenting Author: Yujie Xu
Submitting Author: Yujie Xu

Description:

Vulvodynia is a chronic condition causing persistent vulvar pain, significantly impairing women's quality of life. Electroacupuncture (EA) has demonstrated therapeutic potential in alleviating vulvodynia, though the underlying mechanisms remain unclear. This study provides a systematic evaluation of a vulvodynia mouse model, examining the effects of EA on vulvar pain. Our results reveal that EA significantly alleviates pain in the vulvar region. Furthermore, we identify the Piezo2 ion channel at the Sanyinjiao acupoint as a key target mediating the analgesic effects of EA. These findings suggest a novel mechanism for EA in treating vulvodynia, offering potential therapeutic insights for clinical application.

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CAN OBESITY INCREASES MECHANO-ALLODYNIA IN RATS WITH OSTEOARTHRITIS?

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Kim Henriksen
Presenting Author: Andrea Bezerra
Submitting Author: Andrea Bezerra

Description:

Obesity is described as an important risk factor for chronic pain development (1). The systemic and local inflammation, as well as overload in the joints are described as important mechanisms for pain onset and development in this population (2,3). In patients with knee osteoarthritis (OA) the perception of pain seems to correlate directly with body weight (4). To better explore how obesity can lead to pain amplification, this study aims to explore the role of obesity on mechanical allodynia and thermal hypersensitivity in rats submitted to OA-induced surgery

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Human Osteoarthritis Synovial Fluid Reveals Neuropilin-1 as a Driver of NGF-Mediated Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Nigel W Bunnett
Presenting Author: Elisa Damo
Submitting Author: Elisa Damo

Description:

Osteoarthritis (OA) affects more than 1 out of 7 adults in the U.S. and is the leading cause of chronic pain and disability (1). Although Nerve Growth Factor (NGF) is a validated target for OA pain management (2), clinical trials using NGF-targeting monoclonal antibodies have been limited by serious adverse effects, including joint damage (3, 4). These limitations highlight the need for safer and more selective therapeutic strategies. We identified Neuropilin-1 (NRP1), a non-signaling transmembrane receptor, as a novel co-receptor and modulator of NGF-induced pain signaling (6); however, its role in NGF-mediated OA pain has not been defined.

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The role of Leukaemia Inhibitory Factor in Inflammatory Arthritis Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Franziska Denk
Presenting Author: Julia Vlachaki Walker
Submitting Author: Julia Vlachaki Walker

Description:

The development of disease-modifying anti-rheumatic drugs (DMARDs) has been revolutionary for the treatment of Rheumatoid Arthritis (RA). However, many patients continue to experience pain despite reduced inflammation. One treatment that has shown promise in treating RA pain is JAK inhibition (JAKi), however concerns over potential cardiovascular and oncogenic side effects have been raised, limiting prescription(1). Cytokines upstream of the JAK-STAT pathway, such as Leukaemia Inhibitory Factor (LIF) and Interleukin 6 (IL-6) are enriched in RA Synovial Fluid and can induce JAK-STAT pathway activation in cultured human sensory neurones(2). Here we investigate the potential role of LIF in RA pain.

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Treadmill Exercise Downregulates Pro-algesic Neurotrophins in an Osteoarthritis Pain Model

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Radica Stepanović-Petrović
Presenting Author: Katarina Nastić
Submitting Author: Katarina Nastić

Description:

Osteoarthritis is the most common rheumatic disorder and a leading cause of disability worldwide1. Exercise is recommended as a first-line non-pharmacological intervention as it reduces pain and improves function in those with the condition1,2,3. However, the biological mechanisms underlying these effects are not yet fully understood. Neurotrophic factors have emerged as promising targets for the treatment of musculoskeletal pain4. Therefore, we aimed to examine the effects of exercise on pain-related behavior and the gene expression of neurotrophins (NGF and BDNF) in the dorsal root ganglia (DRG) and spinal cord in a rodent model of osteoarthritis induced by monoiodoacetate (MIA).

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Intra-articular cannabidiol reduces hypersensitivity in MIA-induced TMJ osteoarthritis model

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Luiz Guilherme Spadon-Brito
Presenting Author: Luiz Guilherme Spadon-Brito
Submitting Author: Luiz Guilherme Spadon de Brito

Description:

Osteoarthritis (OA) of the temporomandibular joint (TMJ) is a highly prevalent condition associated with chronic pain, functional impairment, and a substantial reduction in quality of life. The endocannabinoid system has emerged as a promising therapeutic target for OA, and cannabidiol (CBD), a non-psychoactive phytocannabinoid derived from Cannabis sativa, has demonstrated anti-inflammatory, analgesic, and neuroprotective effects in experimental models. This study aimed to investigate whether intra-articular administration of CBD into the TMJ attenuates orofacial mechanical hypersensitivity in rats with monoiodoacetate (MIA)-induced TMJ OA.

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Peripheral Nerve Pulsed Radiofrequency Modulates Neuroimmune Mechanisms in Knee Osteoarthritis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Takeshi Yoshida
Presenting Author: Momoyu Yamanaka
Submitting Author: Momoyu Yamanaka

Description:

Knee osteoarthritis (OA) pain comprises not only nociceptive pain caused by structural degeneration or synovitis, but also central sensitization leading to chronic pain [1]. Pulsed radiofrequency (PRF) is a neuromodulatory technique that delivers intermittent high-frequency electrical currents to peripheral nerves while maintaining tissue temperatures below 42 °C [2]. Although PRF has shown safety and analgesic efficacy in knee OA [3], its mechanisms remain unclear. Our previous studies demonstrated that sciatic nerve PRF suppresses MIA-induced arthritis and modulates axonal transport in C-fibers. This study aimed to elucidate the central neuroimmune mechanisms underlying PRF-induced analgesia in a mouse OA model.

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Sex differences in spontaneous nociception in an osteoarthritis mouse model

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Kazuhiro Hayashi
Presenting Author: Yui Fukushima
Submitting Author: Yui Fukushima

Description:

Osteoarthritic pain is classically considered a nociceptive pain resulting from abnormal joint loading. Recently, the existence of a neuropathic component in osteoarthritic pain has been proposed in both human and rodent studies. Brain-derived neurotrophic factor (BDNF) in sensory neurons contributes to pain in male neuropathic pain models. In rodent models, the effects of neuropathic pain are greater in males than those in females across several behavioral paradigms. However, the sex differences in the monoiodoacetate-induced osteoarthritis model remain unclear. This study aimed to compare sex differences in pain-related behaviors and to examine BDNF expression in a monoiodoacetate-induced osteoarthritis model.

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TRPV1 Mediates Stress-induced Mechanical and Cold Hypersensitivity in Female Mice

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Tékus Valéria
Presenting Author: Bani Ata Mohammad Izzeldeen Ali
Submitting Author: Mohammad Bani Ata

Description:

Chronic psychosocial distress is an etiological and aggravating factor of several chronic pain conditions including fibromyalgia characterized by chronic widespread musculoskeletal pain [1,2]. Although neuroinflammation is suggested to be involved in its background, the complex pathophysiological mechanisms remain unclear [2,3]. Transient Receptor Potential Vanilloid 1 (TRPV1) and Ankyrin 1 (TRPA1) are heat-, inflammation- and cold-sensing cation channels commonly co-localized on neurons medicating pain, but their roles in stress-related pain are unknown [4,5,6,7]. Therefore, we investigated their involvement in stress-induced pain models of mice related [8,9,10].

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T and B lymphocytes mediate chronic immobilization-induced pain responses in male mice

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Valéria Tékus
Presenting Author: Eszter Kepe
Submitting Author: Eszter Kepe

Description:

Chronic stress induces and aggravates many chronic pain conditions, such as widespread musculoskeletal pain in fibromyalgia, but the pathophysiological mechanisms are not fully understood. Autoimmunity and neuroimmune interactions have been considered as primary causes, where T and B lymphocytes play key roles. Therefore, the involvement of these cells in chronic stress-induced pain, anxiety and depression-like behaviour was investigated using lymphocyte-deficient mice.

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Limbic White Matter Mediates TLR4 Immunoreactivity and Widespread Pain in Female Chronic Pelvic Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Andrew D. Schrepf, Ph.D
Presenting Author: Ravi R. Bhatt, Ph.D
Submitting Author: Ravi Bhatt

Description:

Chronic pelvic pain is a common, debilitating condition that is often treatment-resistant. The MAPP Network has identified local and widespread pain subtypes, with widespread pain in females linked to heightened innate immune activation via Toll-like receptor 4 (TLR4) pathways (1). Because widespread pain responds preferentially to centrally-acting therapies, peripheral immunoreactivity likely reflects or drives central sensitization, yet the specific brain changes involved remain unknown. Diffusion MRI (dMRI) provides sensitivity to microstructural alterations associated with neuroinflammation that conventional imaging cannot detect (2). We apply advanced diffusion measures to identify CNS mechanisms linking TLR4-mediated immunoreactivity to pain widespreadness in chronic pelvic pain.

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Safety and tolerability of capsaicin (179 mg/ 8%) patch in Post Surgical Neuropathic Pain (RISE)

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Mark S. Wallace
Presenting Author: Mariana Napoles
Submitting Author: Marielle Eerdekens

Description:

Post-surgical neuropathic pain (PSNP) is a serious health concern with ≥ 300 million surgical interventions/year worldwide of which ~10% result in chronic pain including 33-68% with neuropathic features. It causes disability, reduced quality of life and increased use of health care resources [1].
Guidelines for peripheral neuropathic pain (PNP) recommending use of α2δ-ligands, SNRIs and TCAs are usually followed for PSNP treatment. These treatments may be associated with tolerability limitations [2], restrictions for use in special populations and drug-drug interactions. Topical approaches without systemic exposure may be preferred especially if the area affected is small as in PSNP.
High-concentration capsaicin (179 mg/8%) patch (HCCP) is a topical treatment applied to the area affected by neuropathic pain. It releases capsaicin, a selective transient receptor potential vanilloid 1 (TRPV1) agonist providing analgesia via temporary neurolysis of nociceptive nerves [3,4]
Safety/tolerability data from a randomized controlled trial (RCT) are presented.

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A Study to Determine The Incidence of Phantom Limb Pain After Limb Amputation In Sri Lanka.

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Vasanthi Pinto
Presenting Author: Vasanthi pinto
Submitting Author: Vasanthi Pinto

Description:

Painful or non-painful abnormal unpleasant sensation of an absent limb following amputation is explained as a phantom complex. Pain after amputation could be of two types: Phantom limb pain. (PLP) or residual pain (stump pain). The latter is common in the postoperative period and tends to resolve. Both conditions can coexist as well. Recent studies on PLP in the literature have reported rates as high as 80%. There were no reported studies conducted in Sri Lanka, and the incidence is not available. This is probably due to a lack of presentation for medical attention, a lack of awareness of the disease among patients and medical practitioners, a paucity of specialised treatment modalities, and misdiagnosis.
This study aims to determine the incidence and factors influencing the presentation, severity and medical attention in PLP in Sri Lanka.

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Real-World Outcomes of Interlaminar vs Transforaminal Epidural Injection for Lumbar Disc Herniation

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Xia Feng
Presenting Author: Ming Wei
Submitting Author: Ming Wei

Description:

Interlaminar (ILEI) and transforaminal (TFEI) epidural injections are commonly used for radicular pain in lumbar disc herniation (LDH), with prior comparative studies largely focusing on pain relief and functional outcomes. However, outcomes that may influence real-world treatment pathway selection, such as quality of life, treatment burden, and economic cost, remain insufficiently addressed. This study aimed to compare ILEI and TFEI in patients with LDH from a real-world clinical perspective, incorporating patient-centred and decision-relevant outcomes to better inform individualized pathway selection.

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Brain mechanisms supporting movement-evoked pain flares in patients with chronic low back pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Fadel Zeidan
Presenting Author: Morgan Gianola
Submitting Author: Morgan Gianola

Description:

Chronic low back pain (cLBP) is the leading cause of disability globally[1] and commonly exacerbated by movements such as bending over or lifting objects[2-3]. The transition from acutely evoked to stabilized neuroplastic chronic pain is associated with higher self-referential, sensory and nociceptive processing. However, neural mechanisms supporting movement-evoked pain in cLBP remain poorly characterized. The leg raise test (LRT), an ecologically validated cLBP evoking technique[4-5], increases activity in pain-related areas including primary (SI) and secondary somatosensory cortices (SII), insula[6-7], superior parietal lobule[5], and self-referential processing in regions of the default mode network (DMN)[8-11]. This study examined behavioral and neural responses to the LRT using arterial spin labeling (ASL) functional MRI[12-13] in patients diagnosed with lumbar radiculopathy. We hypothesized that the LRT would significantly increase self-reported pain and cerebral blood flow (CBF) in brain regions supporting nociceptive (SI, insula), sensory discriminative (parietal lobe) and self-referential (precuneus, medial prefrontal cortex) processing.

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Factors associated with neuropathic pain medication effectiveness: a cross-sectional study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Prof Lesley Colvin
Presenting Author: Ms Mia Koponen
Submitting Author: Mia Koponen

Description:

Neuropathic pain (NeuP) is common, debilitating, and notoriously difficult to treat.[1,2] The first-line medications – including gabapentinoids, tricyclic antidepressants, and serotonin-norepinephrine reuptake inhibitors – only provide clinically meaningful pain relief to a subset of people.[3] Despite substantial inter-individual variability in treatment response, current clinical guidelines lack evidence to support personalised prescribing. As a result, many people undergo prolonged trial-and-error treatment and experience avoidable adverse effects. Identifying predictors of treatment response could enable more targeted prescribing, improve treatment outcomes, and reduce treatment burden. Therefore, this study aimed to identify factors associated with the effectiveness of first-line NeuP medications.

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IncobotulinumtoxinA in Postherpetic Neuralgia: Sustained Pain Improvement in the PaiNT Phase 2 Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Nadine Attal
Presenting Author: Nadine Attal
Submitting Author: Nadine Attal

Description:

Postherpetic neuralgia (PHN) causes persistent, often debilitating peripheral neuropathic pain (PNP) that can greatly restrict daily life. Many patients continue to struggle due to shortcomings of available treatments, highlighting the need for approaches that can meaningfully ease pain over time. The PaiNT study addresses this need by investigating how average daily pain (ADP) evolves over 20‑weeks in patients receiving a single incobotulinumtoxinA (incoBoNT-A, Xeomin®) treatment.

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Factors associated with unsuccessful treatment outcomes in individuals with neuropathic pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Pramote Euasobhon
Presenting Author: Pramote Euasobhon
Submitting Author: Pramote Euasobhon

Description:

Neuropathic pain is generally more challenging to manage than other chronic pain conditions, and treatment success rates remain suboptimal. While prior studies have provided insights into chronic pain, data specifically identifying factors associated with outcomes in neuropathic pain are limited. The primary objective of this study was to determine risk factors associated with unsuccessful outcomes in patients with neuropathic pain. Secondary objectives were to evaluate overall treatment effectiveness and to determine the incidence of treatment-related adverse events.

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High-dose cannabidiol in spinal cord injury chronic neuropathic pain: An RCT and brain imaging study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Iain S McGregor & Luke A Henderson
Presenting Author: Rebecca V Robertson
Submitting Author: Rebecca Robertson

Description:

This is the first randomised, placebo controlled trial to evaluate high dose cannabidiol (CBD) with concurrent brain imaging in people with spinal cord injury (SCI) neuropathic pain. Chronic neuropathic pain is common after SCI, yet current treatments have limited efficacy and significant side effects1,2. Cannabidiol (CBD), a non-intoxicating component of cannabis, has demonstrated efficacy in preclinical models of neuropathic pain3–5. In individuals with SCI chronic neuropathic pain, we investigated the effect of high-dose (800 mg/day) CBD on pain intensity and associated changes in brain activity using magnetic resonance imaging (MRI).

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5% Dextrose Hydrodissection with FlexorRetinaculum Fenestration for Carpal Tunnel Syndrome

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Suspa Das
Presenting Author: Sandeep margan
Submitting Author: Sandeep Margan

Description:

Carpal tunnel syndrome (CTS) is the most prevalent entrapment neuropathy, resulting from median nerve compression within the carpal tunnel. Ultrasound-guided 5% dextrose (D5W) hydrodissection has demonstrated clinical improvement by separating the median nerve from surrounding subsynovial connective tissue and reducing neurogenic inflammation. However, persistent mechanical constraint from a thickened flexor retinaculum may limit sustained decompression. Mechanical fenestration of the flexor retinaculum, performed under ultrasound guidance, may enhance decompression by disrupting fibrotic bands and increasing tunnel compliance. Combining fenestration with D5W hydrodissection theoretically provides both structural release and biological modulation, potentially improving symptom relief and functional recovery compared with hydrodissection alone.

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Effect of Transforaminal Epidural Steroid Injections on Gabapentinoid Use in Lumbar Radicular Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Osman Hakan Gunduz, Prof.
Presenting Author: Savas Sencan, Assoc. Prof.
Submitting Author: Nurbanu Hindioglu Dogan

Description:

Lumbar radicular pain is a common neuropathic condition most frequently caused by lumbar disc herniation and spinal stenosis. Gabapentinoids are widely used for its management; however, long-term use is limited by modest efficacy, adverse effects, and concerns regarding misuse. Transforaminal epidural steroid injections(TFESI) provide targeted anti-inflammatory treatment and are supported by strong evidence for radicular pain relief. While previous studies have compared the efficacy of gabapentinoids and epidural injections, data on the impact of TFESI on gabapentinoid use are limited. This study aimed to evaluate changes in gabapentinoid use and pain intensity following TFESI in patients with lumbar radicular pain.

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THE EFFECTIVENESS OF INTERLAMINAR LUMBAR EPIDURAL STEROID INJECTION IN LUMBAR CANAL STENOSIS

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: I Made Phala Kesanda
Presenting Author: Stefani Luziani
Submitting Author: Stefani Luziani

Description:

Lumbar canal stenosis is a common cause of chronic low back pain in older adults and frequently presents with neurogenic claudication, resulting in significant functional limitation. Interlaminar lumbar epidural steroid injection (ILESI) has been proposed as a minimally invasive treatment option for patients who do not respond adequately to conservative therapy before surgical intervention is considered. In addition to its anti-inflammatory effects, ILESI may also provide mechanical benefits by facilitating the release of the epidural space and reducing the risk of re-adhesion. This study aimed to evaluate the clinical effectiveness of C-arm–guided ILESI in patients with lumbar canal stenosis.

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The use of 5Hz bursts may help improve refractory chronic lower back pain.

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: sylvie raoul
Presenting Author: sylvie raoul
Submitting Author: Sylvie Raoul

Description:

Objective :
Chronic low back pain is a common cause of disability and one that is difficult to treat effectively but PNFS can be effective to treat patients. But sometimes the efficiency was decreased during time. To increase the benefice of this therapy, burst 5Hz was tried to decrease pain.

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Analysis Of The Efficacy Of SCS Combined With Intraspinal Block In The Treatment Of PHN In Elderly

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Tian wenhai
Presenting Author: Tian wenhai
Submitting Author: tian wenhai

Description:

To investigate the efficacy of SCS combined with intrathecal block in the treatment of PHN in elderly patients.

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Endoscopic Discectomy vs Collagenase Chemonucleolysis for Single-Level Cervical Disc Herniation

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Wang Likui
Presenting Author: Wang Likui
Submitting Author: Likui Wang

Description:

Posterior Full-Endoscopic Cervical Discectomy (PFECD) and Collagenase Chemonucleolysis (CCNL) are two effective minimally invasive surgical approaches for treating Cervical Spondylotic Radiculopathy (CSR). By analyzing their clinical efficacy, this study aims to provide available insights for the clinical management of CSR.

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Cervical atrophy after thoracic spinal cord injury: role of neuropathic pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Sylvia Gustin
Presenting Author: Yann Quidé
Submitting Author: Yann Quidé

Description:

Spinal cord injury (SCI) results in neurodegeneration both at and above the lesion site. While cervical cord atrophy is well characterized in populations of mixed cervical, thoracic and/or lumbar injuries, the remote morphological changes in cervical cord following isolated thoracic SCI remain unclear. The present study aimed to quantify cervical spinal cord morphology at C2-C3 in individuals with thoracic SCI and compare these metrics to matched controls.

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MRI MDI sequence identifies cortical biomarkers of central sensitization in neuropathic pain.

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Shuiqing, Li
Presenting Author: Yuanren, Zhai
Submitting Author: Yuanren Zhai

Description:

Abnormal central pain sensitization may serve as a potential explanation for persistent neuropathic pain after lumbosacral radicular pain surgery, yet its exact mechanism remains unclear. This study aimed to investigate cortical pattern changes in patients with chronic neuropathic pain secondary to lumbosacral radicular pain.

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BTX-A Subcutaneous Injection Combined with SCS for PHN: An Efficacy Observation

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Huacheng Zhou
Presenting Author: zhuohang Li
Submitting Author: huacheng zhou

Description:

Botulinum toxin type A (BTX-A) and spinal cord stimulation (SCS) treat postherpetic neuralgia (PHN) via peripheral and central mechanisms, respectively. Combining both may enable multi-target synergy, yet clinical evidence remains limited. This study evaluates the efficacy of BTX-A + SCS in PHN patients to inform practice.

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Treatment Response of Long COVID and Fibromyalgia to Systolic Extinction Training.

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dennis C Turk
Presenting Author: Kati Thieme
Submitting Author: Kati Thieme

Description:

Both Long COVID (LCOV) and fibromyalgia (FM) share common symptoms (e.g., pain, fatigue, cognitive impairment) although the mechanisms involved my vary. Systolic Extinction Therapy [SET] treatment combines operant-behavioral pain therapy and baroreceptor-training (BRT). SET has been shown to be effective in treating patients with FM. Thus, we hypothesized that SET could be extended to treat symptoms of LCOV.

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Chronic pain in long covid: the potential role of childhood trauma, peripheral & neuroinflammation

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Gary Stephens
Presenting Author: Richard Harrison
Submitting Author: Richard Harrison

Description:

Long COVID is characterised by a variety of symptoms that persist for three months or longer after COVID‑19 infection. Long COVID is a multi-system condition, that can be severely debilitating, with the most frequent symptom being reported as chronic pain[1]. Intuitively, chronic pain developing from a respiratory viral infection may be unexpected, however the condition is predominantly associated with chronic inflammation, as with chronic pain[2]. The underlying pathophysiological mechanisms of long COVID, and the development of chronic pain, remain unclear[3]. This study aimed to better understand the individual differences and biomarkers that may underlie chronic pain in long COVID.

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Comparative Analysis of Functional Connectivity between Fibromyalgia and Long COVID Patients

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Tomohiko Aoe
Presenting Author: Tomohiko Aoe
Submitting Author: Tomohiko Aoe

Description:

Fibromyalgia, characterized by generalized pain, and chronic fatigue syndrome, characterized by fatigue, are both diagnosed based on the patient's subjective complaints. Their pathogenesis remains unclear. A link between these conditions and viral infections has been suggested. Recently, many patients have complained of fatigue and generalized pain as aftereffects of COVID-19, and long COVID can be considered a pathological model for fibromyalgia and chronic fatigue syndrome after viral infection. Therefore, we conducted a comparative study of functional changes in the central nervous system between patients with long COVID and those with fibromyalgia and chronic fatigue syndrome using resting-state functional MRI analysis.

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Duloxetine Prevent Chronic Postsurgical Pain After Inguinal Hernia Repair in Patients at High Risk?

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Antonio Montes
Presenting Author: Antonio Montes
Submitting Author: ANTONIO MONTES

Description:

We aim to conduct a randomized placebo-controlled trial comparing the usefulness of a medical strategy for preventing the development of chronic postsurgical pain (CPSP) after inguinal open hernia repair. This is a continuation of our previous studies in which we established a presurgical model (GENDOLCAT) to identify patients at high risk for CPSP (1). The risk model is based on six clinical predictors: surgical procedure, age, physical health (Short Form Health Survey-12 [SF-12]), mental health (SF-12), preoperative pain in the surgical field, and preoperative pain in another area; and was then externally validated after the development study (2).

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Central Sensitization and Autonomic Function in Postsurgical Pain: A Report from the rTSA-PRO Cohort

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Jason Zafereo, PT, PhD
Presenting Author: Cassie M. Argenbright, PhD
Submitting Author: Cassie Argenbright

Description:

Postsurgical pain is complex and heterogeneous, with individuals exhibiting variable postoperative responses across multidimensional recovery domains, including sensory and affective outcomes. Central nervous system mechanisms are increasingly recognized as contributors to persistent postsurgical pain, particularly through domains of heightened processing, such as central sensitization (CS), or systemic physiological stress, such as autonomic regulation. However, the distinct roles of CS and autonomic function in shaping multidimensional postsurgical pain trajectories remain unclear. Therefore, this study examined central sensitization symptoms and autonomic function, as indexed by HRV, in relation to preoperative pain phenotypes and early postoperative pain, affective symptoms, and sensory processing outcomes.

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Plasma Biomarkers Predict Post-Operative Pain after Total Knee Arthroplasty: Results from PRIME-Knee

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Cathleen Colón-Emeric, MD
Presenting Author: Corey B. Simon, DPT, PhD
Submitting Author: Corey Simon

Description:

Over 20% of older adults after total knee arthroplasty (TKA) report persistent post-operative pain (POP; post-surgical pain ≥ 6 months). TKA POP screening is mostly limited to self-reported measures like pre-operative pain intensity. Blood-based biomarkers, while promising, require a novel approach of data reduction and validation to isolate from inherent patient-specific confounders (age-related biodiversity, comorbidity). We applied such an approach in PRIME-Knee, a prospective cohort study of 203 patients undergoing elective unilateral TKA at Duke. The purpose of PRIME-Knee was to identify predictive biomarkers of resilience outcomes like pain recovery, function, and falls.

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Pain Neuroscience Rehabilitation in Low Back Pain: Chronification and Central Amplification

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Nanda Aulya Ramadhan
Presenting Author: Nanda Aulya Ramadhan
Submitting Author: Nanda Aulya Ramadhan

Description:

Low back pain (LBP) is the leading cause of disability worldwide and often progresses to chronic pain. Although early LBP is mainly nociceptive, persistent symptoms may involve neuropathic features, nociplastic pain, and central sensitization driven by altered pain modulation and impaired descending inhibitory pathways (1). Repeated nociceptive input can promote pain chronification through neuroinflammation, neuroplastic changes, and central nervous system reorganization (2). These mechanisms contribute to central pain amplification, characterized by heightened neuronal excitability and disproportionate pain perception (3). Pain neuroscience–informed rehabilitation aims to reduce peripheral nociceptive input while restoring adaptive central pain modulation.

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Persistent Post-Surgical Pain Burden in Chronic Pain OPD: Retrospective Analysis From an Onco-Centre

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: DR APARNA S CHATTERJEE
Presenting Author: DR SUMITRA G BAKSHI
Submitting Author: Sumitra Bakshi

Description:

Persistent post-surgical pain (PPSP)can impact quality of life 1. Onco-surgeries are known to be associated with PPSP (2-4). Our hospital is a tertiary onco-centre. The primary aim of this study was to ascertain the percentage of patients presenting to the pain clinic with post-surgical pain. In addition we wanted to assess the severity of pain, to compare the known pre-operative, intra-operative and post-operative risk factors associated with potential transition to PPSP and identify the sub group of oncological surgeries that are more prone to PPSP.

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The Silent Gut & Screaming Nerve: Multimodal Rescue of Pediatric Hostile Abdomen

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr. Maria Elena Basco-Tiamson
Presenting Author: Dr. Tiffany Joy Chavez
Submitting Author: Tiffany Joy Chavez

Description:

Pediatric "hostile abdomen" syndrome presents a complex therapeutic challenge, characterized by refractory visceral nociception and extensive adhesive disease. Standard mu-opioid monotherapy often fails in this setting, precipitating opioid-induced hyperalgesia (OIH) and exacerbating ileus. This case report aims to demonstrate the efficacy of a mechanism-based multimodal analgesic strategy—specifically opioid rotation to kappa-agonists and NMDA receptor antagonism—in a 14-year-old female with a frozen abdomen. Furthermore, we analyze the diagnostic management of rare iatrogenic sequelae, including sensorineural hearing loss and metabolic mimics of neurotoxicity, to highlight critical clinical distinctions in pediatric critical care.

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Pre?operative clinical phenotype and biological pathways in knee and thoracic cohorts of the A2CPS

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Kathleen A Sluka
Presenting Author: Giovanni Berardi
Submitting Author: Giovanni Berardi

Description:

Chronic postsurgical pain (CPSP) results in impaired postoperative long-term outcomes and reduced quality of life. CPSP impacts nearly 20% of patients undergoing knee arthroplasty and 30% of those undergoing thoracotomy. While numerous biopsychosocial factors contribute to the transition to chronic pain, there is limited understanding of biological factors that may contribute to pre-operative disease severity, which may increase risks for adverse health outcomes. This study aimed to characterize pre‑operative clinical phenotypes using biopsychosocial measures and to determine the metabolomic and proteomic pathways associated with clinical severity. This is a secondary analysis from the A2CPS baseline data (v2.1.0).

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Biopsychosocial phenotypes of CPSP: physical activity, biomarkers and cortical activity

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Christine B Sieberg
Presenting Author: Guillermo Ceniza-Bordallo
Submitting Author: Guillermo Ceniza-Bordallo

Description:

Although chronic postsurgical pain (CPSP) in adolescents and young adults (AYAs) is increasingly recognized as a heterogeneous
condition, existing studies have largely examined psychological, physiological, or neurobiological factors in isolation. Critically, no prior work has integrated
objective physical performance with stress biomarkers and resting-state cortical hemodynamics to identify biopsychosocial phenotypes of CPSP in this
population. Based on these considerations, the aim of this study was to identify biopsychosocial phenotypes of physical performance using a clustering approach
that integrates pain interference, psychological symptoms, physical fitness, hair cortisol concentration, and resting state cortical hemodynamic activity in AYAs
with CPSP.

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Incidence, Onset, and Predictors of Phantom Limb Pain Following Major Limb Amputation

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Sascha Tafelski
Presenting Author: Jan Wandrey
Submitting Author: Jan Wandrey

Description:

Phantom limb pain (PLP) is a prevalent and disabling complication after major limb amputation, yet its mechanisms and predictors remain incompletely understood (1–3). High temporal-resolution longitudinal data characterizing pain quality in the weeks following amputation are scarce (4). Moreover, post-amputation pain is frequently not differentiated into stump pain and phantom limb pain, despite distinct underlying mechanisms and divergent therapeutic implications (5). Against this background, this prospective multicentre observational study aimed to (i) characterize the temporal onset of PLP following major limb amputation and to examine (ii) clinical as well as (iii) systemic inflammatory factors associated with its development.

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Beyond the Limits: Bilateral SSNB for Chronic Shoulder Pain in a Renal-Compromised Triathlete

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Salvador E. Brodit Jr., MD, DPBPM
Presenting Author: Jo Mari Darvin C. Adorador, MD, DPBA
Submitting Author: Jo Mari Darvin Adorador

Description:

Chronic shoulder pain in aging athletes with Chronic Kidney Disease (CKD) creates a complex therapeutic dilemma. Nephrotoxic NSAIDs are strictly avoided, and standard opioids, such as morphine, carry high risks of neurotoxic metabolite accumulation. While pharmacokinetically safer options like fentanyl exist, their utility is often limited by patient refusal, as seen in this case. To bridge this void, we utilized ultrasound-guided Suprascapular Nerve Block (SSNB) with corticosteroid augmentation. We aim to demonstrate that this targeted, organ-sparing intervention bypasses systemic limitations, ensuring targeted relief and restoring high-performance function without compromising renal integrity.

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Psychosocial Biomarkers of the Acute to Chronic Pain Signatures (A2CPS) Program

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Emine Bayman
Presenting Author: Kathleen Sluka
Submitting Author: Kathleen Sluka

Description:

Post-surgical chronic pain is an under-recognized public health problem. Research shows that psychosocial factors are critical to the transition to chronic pain after injury, yet no large-scale comprehensive, multi-modal studies have considered biological factors alongside PROs. The Acute to Chronic Pain Signatures (A2CPS) study of over 2,400 participants examines a comprehensive array of factors including psychosocial factors. The goals of the A2CPS program are to identify individual factors and combined biosignatures that predict the transition from acute to chronic pain.

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Fatigue and Central Pain Processing in Knee OA Independent of Pain (A2CPS)

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Laura Frey-Law
Presenting Author: Laura Frey-Law
Submitting Author: Laura Frey Law

Description:

Knee osteoarthritis (OA) involves both peripheral pathology and altered central nervous system (CNS) pain processing. Approximately 50% of individuals with knee OA report clinically meaningful fatigue. In musculoskeletal conditions, fatigue has been associated with heightened CNS signal processing independent of pain presence. These observations suggest fatigue may share underlying central mechanisms with pain. However, these relationships have not been rigorously examined in knee OA. We aimed to determine whether self-reported fatigue is independently associated with multiple markers of central pain processing: quantitative sensory testing (QST), multisensory sensitivity (MSS), and widespread pain using Acute to Chronic Pain Signatures (A2CPS) baseline data.

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High pain catastrophizing worsens preoperative status but not outcomes after rotator cuff repair

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Masashi Izumi
Presenting Author: Masashi Izumi
Submitting Author: Masashi Izumi

Description:

Pain catastrophizing is a key psychological factor associated with chronic postsurgical pain, particularly after total knee and hip arthroplasty. However, its role in shoulder surgery remains unclear. Arthroscopic rotator cuff repair (ARCR) effectively reduces nociceptive input from structural pathologies, which may influence the impact of psychological factors on outcomes. This study aimed to investigate the association of pain catastrophizing with preoperative status and postoperative outcomes in patients undergoing ARCR.

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Image Processing in the Acute to Chronic Pain Signatures (A2CPS) Project

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Tor D. Wager
Presenting Author: Michael Sun
Submitting Author: Michael Sun

Description:

The Acute to Chronic Pain Signatures (A2CPS) project is a large-scale, multi-site study designed to identify biomarkers that predict the transition from acute to chronic pain following surgery. Chronic post-surgical pain remains a major clinical challenge, yet reliable predictive markers are lacking. A2CPS integrates multimodal neuroimaging with deep clinical, psychosocial, and biological phenotyping in over 2,400 surgical patients. Here, we describe the neuroimaging component of the project and summarize the contents and quality of the initial public data release.

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Acupuncture for Poststroke Shoulder Pain: A Systematic Review and Meta-Analysis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Sung Min Lim
Presenting Author: Sung Min Lim
Submitting Author: Sung Min Lim

Description:

Shoulder pain is the common complaint among patients with stroke. Acupuncture has increasingly been used for shoulder pain treatment after stroke. The aim of the present study was to summarize and evaluate evidence for the effectiveness of acupuncture in relieving poststroke shoulder pain.

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Treatment engagement in a digital psychological intervention for adolescent spinal surgery

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Tonya M Palermo
Presenting Author: Ryan D Parsons
Submitting Author: Ryan Parsons

Description:

Chronic postsurgical pain impacts nearly 1/3 of adolescents 6-12 months after spinal fusion surgery, and can affect long-term functioning and quality of life. We evaluated the effectiveness of digital cognitive-behavioral therapy (CBT) (SurgeryPal) versus digital education (ED) delivered at two phases (pre-operative, post-operative) to reduce acute and chronic pain in adolescents undergoing spine surgery. Our primary trial findings demonstrated that groups receiving CBT compared to ED had lower pain interference, depression, and improved sleep at follow-up. The aim of this secondary analysis is to assess participant engagement with the digital interventions, perceived treatment acceptability, and association with perioperative treatment outcomes.

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Intravenous Lidocaine and Chronic Postsurgical Pain: A Systematic Review and Meta-Analysis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr. Narinder Singh
Presenting Author: Simrit Rana
Submitting Author: Simrit Rana

Description:

Chronic postsurgical pain (CPSP) is pain that develops or increases following surgery, persists ≥3 months after surgery, and is not attributable to other causes.¹The median incidence at 6-12 months is approximately 20-30%, with incidence rising alongside high-risk surgical procedures and inflammatory disease.²Intravenous (IV) lidocaine has emerged as a potential preventive strategy due to its anti-nociceptive effects, including modulation of central sensitization.³In chronic pain populations, lidocaine infusions have demonstrated analgesia at plasma concentrations of 2–3 mg/mL.⁴However, evidence for its efficacy in preventing CPSP remains heterogeneous across surgical populations and dosing regimens, warranting a focused synthesis.

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Electronic Health Records Acquisition and Processing in the Acute to Chronic Pain Signatures Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Robert McCarthy
Presenting Author: Stephani Sutherland
Submitting Author: Stephani Sutherland

Description:

The Acute to Chronic Pain Signatures (A2CPS) study is a large, multisite, longitudinal observational project aimed at identifying biomarkers predictive of the transition from acute to chronic pain following total knee arthroplasty and thoracic surgery (n=2400). A key component of the study is the integration of Electronic Health Record (EHR) data collected from seven healthcare systems across two Multisite Clinical Centers.

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Gut Microbiome Composition Associated with Post-Surgical Pain: A Systematic Review

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Shiqian Shen
Presenting Author: Stephanie Ponsonby
Submitting Author: Stephanie Ponsonby

Description:

Post-surgical pain reduces quality of life and increases healthcare costs. Approximately 10-50% of surgical patients develop Persistent Post-Surgical Pain (PPSP), defined as new or worsening pain persisting >3 months post-operatively. The mechanisms underlying individual variability in pain sensitization after surgery remain incompletely understood, limiting identification of high-risk patients. The gut microbiome comprises thousands of bacterial species, which have been associated with multiple pain conditions through gut-derived metabolites. This systematic review examined whether gut microbiome composition differs between patients who develop PPSP and controls. Secondary objectives assessed microbiome differences in acute post-surgical pain (<7 days post-surgery).

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Cancer Treatment-Related Pain in Patients with Refractory Pain: A Registry Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Uri Hochberg
Presenting Author: Uri Hochberg
Submitting Author: Uri Hochberg

Description:

Cancer treatment–related pain (CTRP) is an often-under-recognized contributor to chronic pain in cancer survivors, yet its prevalence and clinical characteristics in refractory pain populations remain poorly defined. The objective of this study was to quantify the prevalence and characterize the demographic and clinical presentation of CTRP relative to tumor-related pain in a tertiary refractory pain cohort.

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When the Scar Hurts: Postoperative Anterior Cutaneous Nerve Entrapment Syndrome

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Vindu Yadav
Presenting Author: Vindu Yadav
Submitting Author: Vindu Yadav

Description:

Chronic abdominal wall pain is frequently misdiagnosed as visceral pathology, resulting in unnecessary investigations and prolonged morbidity. Anterior cutaneous nerve entrapment syndrome (ACNES) is the most common cause of abdominal wall pain and may occur following abdominal surgery due to scar-related nerve entrapment. Diagnosis is clinical, supported by a positive Carnett’s sign and response to local anaesthetic injection. We present a case of postoperative ACNES to highlight key diagnostic features and the therapeutic role of ultrasound-guided rectus sheath block with hydrodissection.

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Innovative Cost-Effective Hyperosmolar Dextrose Ganglion Impar Block for Post-Traumatic Coccydynia

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Helen Gharaei
Presenting Author: Achmad Harun Muchsin
Submitting Author: Achmad Harun

Description:

Background:
Chronic post-traumatic coccydynia frequently remains refractory to conservative and interventional management, particularly in the presence of structural abnormalities such as coccygeal subluxation or abnormal angulation. Ganglion impar block (GIB) is an established intervention for sympathetically mediated coccygeal pain. However, traditional neurolytic agents such as alcohol or phenol are limited by safety concerns, including non-selective tissue necrosis and higher costs.

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The Use By Ozone And A Parasympathomimetic Drug In Liposome On Shoulder After Trauma Or Surgery.

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Marinoni Margherita
Presenting Author: Boglioni Gabriele
Submitting Author: Maria Margherita

Description:

Verify the pain relief by applying a parasympathomimetic drug in liposomes cream on the shoulder's skin and Ozone's injections in a group of patients suffering from painful shoulder, after trauma or surgery.

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Non-invasive Peripheral Neuromodulation for Managing Post-amputation Pain: a Prospective Case series

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr Arun Bhaskar
Presenting Author: Dr Arun Bhaskar
Submitting Author: Arun Bhaskar

Description:

The war between Ukraine and Russia has resulted in hundreds of thousands of casualties due to drone strikes, artillery shelling, bomb blasts and high velocity gunshot injuries. Some of these patients with life-altering injuries have required limb amputations, lower or upper or both; poorly managed pain has impacted on the quality of life, often delaying rehabilitation and mobilisation with prosthesis. Opioid management and effective invasive interventions are limited in Ukraine due to the ongoing conflict. We are reporting an update on a prospective study on the use of a patented high frequency non-invasive peripheral neurostimulation for managing post-amputation pain.

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Pain Management in Patient with Hypertrophic Non-Obstructive Cardiomyopathy in an Orthopedic Surgery

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr Deepa K Khurana
Presenting Author: Dr Sunil
Submitting Author: SUNIL SUNIL

Description:

Pain management and anaesthesia in patients with pre-existing cardiac conditions presents significant challenges.¹ Hypertrophic cardiomyopathy (HOCM) is a myocyte disease causing increased left ventricular wall thickness and may lead to left ventricular outflow obstruction , arrhythmias etc.² Anaesthesia in HOCM cases should aim to maintain good pain management & cardiac output, control heart rate and minimize excessive sympathetic tone.³
We discuss perioperative Pain management of a patient with HOCM undergoing Anterior Cruciate Ligament reconstruction with Medial Meniscus repair.

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Prevalence and Characterization of Pediatric-onset Spinal Cord Injury Pain as Reported by Youth

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Julian Taylor
Presenting Author: Julian Taylor
Submitting Author: Julian Taylor

Description:

Pain in pediatric-onset spinal cord injury (SCI) has an unknown prevalence and genetic basis. Cold hyperesthesia is also a key sensory sign in adults with SCI pain. This hypothesis-driven observational and genetic-phenotype study assessed transient receptor potential ankyrin 1 (TRPA1) gene single-nucleotide polymorphism (SNP) clusters rs920829, rs11988795, and rs13255063 as factors associated with pediatric-onset SCI pain.

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Use of Acupuncture in Traumatic Amputees: a Population Based Historical Cohort Study in South Korea

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: KUNHYUNG KIM
Presenting Author: KUNHYUNG KIM
Submitting Author: KUN HYUNG KIM

Description:

Patients with traumatic limb amputation often require long-term rehabilitation and health service access. Burden of substantial morbidity and physical inactivity due to disability is likely to increase risk of mortality. Few information from population-based studies is available, however, highlighting evidence gap on prognosis and use of healthcare resources after traumatic limb amputation. This study aimed to estimate five-year mortality, use of healthcare services specifically focused on acupuncture, visit to physician due to pain, and opioid prescription in adults after traumatic limb amputation in South Korea.

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Bilateral Pain Relief Achieved With Unilateral Occipital Peripheral Nerve Stimulation: Case series

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Tigran Kesayan
Presenting Author: Amanda Toye
Submitting Author: Amanda Toye

Description:

Unilateral occipital nerve stimulation (ONS) may provide bilateral analgesia, but evidence is limited. We reviewed five patients with bilateral occipital neuralgia who received a 60‑day unilateral ONS lead at the C2–C3 junction. All experienced clinically meaningful improvement, with four reporting ≥75% bilateral pain reduction and decreased migraine burden. Several demonstrated sustained benefit for months after explant, including complete remission in two cases. Findings support modulation within the trigeminocervical complex and central pain networks as mechanisms for contralateral and durable analgesia.

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What We Know About Psychosocial Factors in Shoulder Pain May Be Biased by Research Context: A Review

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Federico Pozzi
Presenting Author: Lucas Almeida
Submitting Author: Lucas Almeida

Description:

Shoulder pain is a debilitating condition that affects people across diverse demographic contexts. Psychosocial factors influence pain and disability outcomes; however, it remains unclear whether evidence represents different countries’ income levels and racial/ethnic groups. Socioeconomic status, race, and ethnicity shape experiences of pain and access to care, suggesting that research context may influence the observed psychosocial-pain relationship. A lack of equality, diversity, and inclusivity in shoulder pain research limits the applicability of current evidence to underserved populations. Our scoping review mapped the distribution of studies on psychosocial factors in shoulder pain across country income levels and racial/ethnic representation

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Efficacy of Greater Occipital Nerve intervention in Managing Chronic Migraine Headache

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr Ravi Shankar Sharma
Presenting Author: Dr Ganesh Ramaji Nimje
Submitting Author: GANESH RAMAJI NIMJE

Description:

Chronic migraine causes severe functional disability, often unresponsive to standard pharmacotherapy. (1-3) Ultrasound-guided greater occipital nerve (GON) block provides a focused interventional approach to reduce pain transmission through the trigeminocervical pathway.(4,5) The study aims to evaluate the efficacy of ultrasound-guided unilateral GON intervention in chronic migraine patients.

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Transcranial Magnetic Stimulation Combined with Mindfulness for Pain Relief in Women with Migraine

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Fernanda Moura Vargas Dias
Presenting Author: Fernanda Moura Vargas Dias
Submitting Author: FERNANDA MOURA VARGAS DIAS

Description:

Repetitive Transcranial Magnetic Stimulation (rTMS) and Mindfulness have independently been shown to be associated with lower levels and frequency of headaches¹. To date, there is a clear gap in the literature regarding the combined use of these interventions for migraine. Therefore, this study aims to assess the feasibility, regarding recruitment, retention, adherence, safety, and acceptability of a 4-week randomized clinical trial (RCT) combining rTMS and Mindfulness for the treatment of pain, disability, mindfulness state, depression, and anxiety in women with migraine.

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Depression and Anxiety as Predictors of Headache-Related Disability in the Philippines: PNA1DB study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Keanne Paula H. Amamanglon, MD
Presenting Author: Keanne Paula H. Amamanglon, MD
Submitting Author: Keanne Paula Amamanglon

Description:

Headache disorders cause major disability worldwide and are often underrecognized in low- and high-resource settings. In the Philippines, many patients self-medicate and rarely undergo structured disability or mental health assessment. MIDAS quantifies functional impairment, yet attack frequency and pain severity do not fully explain disability. Depression and anxiety commonly co-occur with primary headaches and may worsen disability and chronification. Filipino data on these psychological predictors remain limited. Using the Philippine Neurological Association One Database (PNA1DB), we aim to describe MIDAS disability and depression/anxiety levels, test associations with MIDAS, and identify demographic and clinical factors influencing these relationships in practice.

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Psycho-Emotional and Neurophysiological Mechanisms of Tension-Type Headache in Adolescents

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Kostiantyn Stepanchenko
Presenting Author: Kostiantyn Stepanchenko
Submitting Author: Kostiantyn Stepanchenko

Description:

Pediatric Tension-Type Headache (TTH) presents a significant socio-economic burden. In the studied Kharkiv population, headache prevalence reached 80.2%, yet specific psycho-emotional and autonomic triggers remain poorly understood. This study frames TTH as a clinical indicator of complex psycho-vegetative disorders. We aimed to increase diagnostic and therapeutic efficiency by investigating non-specific cerebral regulatory systems and identifying risk factors for chronification. This multidimensional approach addresses the gap in current pediatric neurology, moving toward a differentiated model of integrated bio-behavioral intervention and enhanced diagnostic accuracy for adolescent populations.

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Comorbid conditions in patients with migraine, cluster headache, and temporomandibular disorders

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Malin Ernberg
Presenting Author: Malin Ernberg
Submitting Author: Malin Ernberg

Description:

Headaches are the most prevalent neurological disorders with more than 90% of the population reporting a lifetime history of headache. The International Classification of Headache Disorders (ICHD-3) describes headaches as primary, e.g. migraine (MI) and cluster headache (CH), and secondary, such as headache attributed to temporomandibular disorders (TMD).
Headaches are associated with psychological distress and impaired quality of life and with high costs for society. However, few studies seem to have investigated comorbid pain conditions in headache populations.
Thus, this study aimed to screen for comorbid pain conditions and psychological distress in people with MI, CH, and headache attributed to TMD.

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Comparative Evaluation of Machine Learning and Large Language Models for Headache Disorders

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Tomás Ward
Presenting Author: Masahito Katsuki
Submitting Author: Masahito Katsuki

Description:

Precise classification of headache disorders is a cornerstone of both clinical management and research. Supervised machine-learning approaches trained on structured clinical data have demonstrated robust diagnostic performance in this domain. In contrast, the diagnostic capabilities of large language models (LLMs), which are increasingly explored in medical applications, remain largely unvalidated for headache classification. To date, no study has directly compared an established machine-learning classifier with an LLM using identical, structured headache questionnaire data and specialist-confirmed diagnoses as the reference standard. This study aimed to address this gap by systematically evaluating and comparing the diagnostic performance of these two modeling approaches.

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Association Between Pain Threshold and Headache Phenotype in Migraine Patients

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Noboru Imai
Presenting Author: Noboru Imai
Submitting Author: Noboru Imai

Description:

In 2023, Ashina et al. reported that the facial mechanical pain threshold assessed by the von Frey test during the interictal period in patients with episodic cluster headache (defining <60 g as mechanical hypersensitivity) was useful in predicting treatment response to galcanezumab. To our knowledge, there have been no reports in Japan evaluating facial pain thresholds using the von Frey test in patients with migraine. Therefore, we conducted the present study.

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High prevalence of anxiety and depression among chronic headache patients: causative fators, likely.

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Ricardo Barbosa
Presenting Author: Ricardo Jorge Barbosa
Submitting Author: RICARDO JORGE VASCONCELOS BARBOSA

Description:

Chronic headache is a common and debilitating problem, especially among women. After the third international classification of headaches has established that mixed and compound types of headaches must be delineated, it was noticed that scalp sensitive neuritis is, when examined, present in almost every migraine patient, also involving inflammation of neck and chest structures. Panic attacks, post-traumatic stress and depression, when routinely investigated in chronic headache patients, is highly prevalent, giving rise to the question of causative role of mind suffering in migraine. We hypothesized that the prevalence of these psychiatric disorders were very high and of a causative role.

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Misalignment Between Patient Causal Beliefs and Cervical Musculoskeletal Disorder in Migraine

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Zhiqi Liang
Presenting Author: Zhiqi Liang
Submitting Author: Zhiqi Liang

Description:

Individuals with migraine frequently experience neck pain, yet patient beliefs regarding causal relationships between these symptoms are poorly understood. These beliefs may influence care-seeking: believing neck pain causes migraine may drive pursuit of neck-focused treatments, while recognising neck pain as a migraine symptom may promote migraine-directed management. This study aimed to determine (a) how often patients believe migraine results from neck pain versus neck pain results from migraine, (b) whether beliefs align with cervical musculoskeletal disorder presence (the primary indicator for neck rehabilitation referral), and (c) care-seeking implications.

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Brief Mindfulness and Reiki Effects on Clinical Pain and Sensory Processing in Knee Osteoarthritis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Eric L. Garland
Presenting Author: Adam W. Hanley
Submitting Author: Adam Hanley

Description:

Chronic knee osteoarthritis (KOA) pain is prevalent[3,10,13] and often inadequately managed with pharmacologic or surgical approaches.[1,2,9,11,14] Complementary therapies such as mindfulness[4,7] and Reiki[8,12,15] show promise, yet their mechanisms remain imprecisely characterized. In a four-arm, placebo-controlled RCT, we evaluated the clinical efficacy of brief Mindfulness-Oriented Recovery Enhancement (B-MORE)[5,6] and Reiki compared to sham Reiki (i.e., “Feiki”) and waitlist control. We further examined whether these interventions modulated peripheral nociceptive sensitivity and central sensitization using quantitative sensory testing (QST). We hypothesized that mindfulness and Reiki would reduce KOA symptom and measurably impact QST indices.

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Pulsed Radio-frequency Application for Shoulder Adhesive Capsulitis. A Revisited Treatment Modality.

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Ahmed Foula, MD
Presenting Author: Ahmed Foula, MD
Submitting Author: Ahmed Foula

Description:

Pulsed radio-frequency (PRF) is non-destructive, safe neuromodulation modality for neuropathic and non-neuropathic pain. Mechanisms of action include: 1-disruption of impulse transmission, 2-neuronal structure modification, 3-neuronal excitation phenomenon, 4-immune-modulatory effect.

Intra-articular PRF targets the peri-capsular sensory nerve endings. This concept depends on bone insulating properties with reduced dilutional effect and deflected RF waves with better therapeutic effect.

Adhesive capsulitis is characterized by shoulder pain with global limitation of movement. Literature review showed neuroanatomical distribution of sensory receptors within the joint complex. Nociceptors are identified in the superior quadrant of the joint including subacromial bursa, anterior glenohumeral capsule, coracoacromial and acromioclavicular ligaments.

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Fibromyalgia is associated with a higher blood-brain barrier permeability than other pain conditions

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Camilla Svensson, Eva Kosek
Presenting Author: Alexander Rosenström
Submitting Author: Alexander Rosenström

Description:

Fibromyalgia is associated with neuroimmune activation [2] and increased glia cell activity [1]. In fact, chronic pain in general is associated with an alteration of the neuroimmune environment [3] - a compartment that has potential to both affect and be affected by the blood-brain barrier. However, the distribution of BBB permeability across pain conditions, and the discrepancies between them, are knowledge gaps that will be important to close for the sake of our understanding of peripheral-central neuroimmune crosstalk and its potential mechanistic contributions to the pathophysiology of different kinds of chronic pain.

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Which biopsychosocial factors best explain ICF domains in chronic non-specific low back pain?

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Rodrigo Luiz Carregaro
Presenting Author: Aline Martins de Toledo
Submitting Author: Aline Martins de Toledo

Description:

Chronic non-specific low back pain (CNLBP) is the leading cause of years-lived with disability worldwide. As CNLBP reflects interacting biopsychosocial factors, pain and disability scores may not fully capture its impact across International Classification of Functioning, Disability and Health (ICF) domains. ICF-informed analyses can highlight modifiable targets and support personalised rehabilitation planning. We examined the associations between clinical, sociodemographic, and psychosocial factors and overall disability, as well as ICF-linked activity/participation and body function domains, in adults with CNLBP. We hypothesised that there would be stronger psychosocial and sociodemographic links with activity/participation, and stronger clinical links with body functions.

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Cocreation of digital resources on pain science education for older adults with chronic pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Anabela Silva
Presenting Author: Anabela Silva
Submitting Author: Anabela Silva

Description:

The involvement of users in the development of digital resources has been advocated to improve their overall quality, usability, and meaningfulness. Including users since the very beginning of the development phase ensures that the resources address their needs and specificities, potentially increasing their impact. This study aims to co-create digital materials (videos) on pain science education (PSE) with older adults with pain and physiotherapists. PSE involves explaining pain-related concepts using lay terms and metaphors, and, therefore, the content covered needs to be aligned with patients’ needs and conveyed in a manner that is appealing and understandable.

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Cognitive Functions and Personality Traits in Fibromyalgia and Chronic Low Back or Cervical Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Andreza Letícia Faria Silva
Presenting Author: Andreza Letícia Faria Silva
Submitting Author: Andreza Letícia Faria Silva

Description:

Fibromyalgia is a multifactorial clinical syndrome characterized by chronic widespread musculoskeletal pain, persistent fatigue, sleep disturbances, and cognitive complaints referred to as “FibroFog,” with significant functional, emotional, and social impact. Studies have investigated alterations in memory, attention, executive functions, and personality traits; however, findings remain heterogeneous, with methodological variability. Most research compares fibromyalgia patients with healthy controls, limiting distinction between syndrome-specific alterations and broader effects of chronic pain. Thus, a gap persists regarding characterization between fibromyalgia and other chronic pain conditions. This study investigates cognitive performance, personality traits, and emotional dysregulation in fibromyalgia versus chronic cervical or low back pain.

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Smallest Worthwhile Improvement in Physical Function Expected from Low Back Pain Apps

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Paulo Ferreira
Presenting Author: Anelise Moreti Cabral Silveira
Submitting Author: Anelise Moreti Cabral Silveira

Description:

The smallest worthwhile improvement has been proposed as a comprehensive measure to address the inherent limitations of earlier methods of estimating treatment effects and determining clinical meaningfulness (1). Despite the increasing popularity of smartphone applications (apps) in musculoskeletal health research, the smallest worthwhile improvement in physical function expected from people with chronic non-specific low back pain (LBP) using apps remains unknown. The purpose of this cross-sectional study was to investigate the smallest worthwhile improvement of smartphone apps for improving physical function in people with chronic non-specific LBP.

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Longitudinal links among catastrophizing, interference and medication use in youth with chronic pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Jordi Miró
Presenting Author: Juan P. Sanabria-Mazo
Submitting Author: Juan P. Sanabria-Mazo

Description:

Cross-sectional studies have reported significant associations between pain catastrophizing and pain medication use in youth with chronic pain; however, longitudinal research is needed to clarify the processes underlying this association. Grounded in the pediatric Fear-Avoidance model, this one-year prospective cohort study examined whether pain interference contributes to the longitudinal association between pain catastrophizing and pain medication use.

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Gender differences in common daily life activities discussed in the patient-physician encounter

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Anke Samulowitz
Presenting Author: Anke Samulowitz
Submitting Author: Anke Samulowitz

Description:

Chronic pain is often a lifelong condition affecting virtually all areas of life (1). As part of the rehabilitation process, most patients with chronic pain need to learn how to live with pain and adjust their daily life activities (1). Patients with chronic pain sometimes meet gendered expectations about how to prioritise among activities and duties (2, 3) but little is known about how gender norms might affect the patient-physician encounter. The aim of this study is to analyse gender differences in common daily life activities performed by individuals with chronic pain and discussed in the patient-physician encounter.

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Principles to Tailor Exercise Interventions for Chronic Knee Pain in Older Adults With Dementia.

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Joke Bradt
Presenting Author: Annalisa Na
Submitting Author: Annalisa Na

Description:

Chronic knee pain is prevalent among community-dwelling older adults, is associated with poor quality of life, and can be further complicated by cognitive impairment, including dementia.1 Physical activity is a recommended first-line treatment; however, existing programs often lack the unique cognitive, behavioral, and environmental considerations of this population, limiting engagement and feasibility.2,3 While clinicians often manage chronic pain in people living with dementia (PLWD), there remains a lack of structured, evidence-informed guidance for adapting physical activity interventions for this group.4,5 Accordingly, there is a need to define program principles to support the development of interventions tailored to individuals’ interests and preserved physical and cognitive abilities, while leveraging empirical knowledge and clinical expertise.6 The aim of this study is to identify key principles for a tailored physical activity program to manage knee pain in PLWD, informed by clinicians and individuals with lived experience (PLWD and care partners).

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Effect of load carriage on spinal alignment in individuals with chronic low back pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Apurba Barman
Presenting Author: Apurba Barman
Submitting Author: Apurba Barman

Description:

External load carriage is a common daily activity that places substantial mechanical demands on the spine. The objectives of this study were to examine the effects of external load on sagittal spinal alignment in patients with CLBP and to identify predictors of load-induced morphological changes.

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Latent Profile Analysis of Chronic Whiplash-Associated Disorders Identifies Four Meaningful Classes

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dave Walton
Presenting Author: Ashley Smith
Submitting Author: Ashley Smith

Description:

People with chronic whiplash-associated disorders (WAD) demonstrate a heterogeneous symptom profile (1). It is unclear if distinct subgroups exist within chronic WAD, which may assist with defining possible future treatment options. The purpose of this study was to identify meaningful subgroups of chronic WAD with similar clinical characteristics.

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Structured Sensory Acuity Training in Chronic Low Back Pain: A Pilot Randomized Controlled Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Ayse GURLUK
Presenting Author: Ayse GURLUK
Submitting Author: AYSE GURLUK

Description:

Non-specific chronic low back pain (NCLBP) is a chronic and fluctuating condition with biopsychosocial etiology. It constitutes a significant global burden due to increasing healthcare costs, rehabilitation needs, and loss of workforce (1, 2). In NCLBP, impaired cortical body representations are associated with decreased sensory acuity, central sensitization, and functional impairment. Sensory acuity training (SAT), which targets cortical restructuring, is a promising approach in chronic pain management (3). The aim of this study was to investigate the effects of structured SAT on pain, functionality, and pain-related sensory and psychosocial outcomes.

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Clinical Efficacy of Serratus Posterior Superior Intercostal Plane Block in Myofascial Pain Syndrome

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Sefa Tan
Presenting Author: Banu Tan
Submitting Author: Sefa Tan

Description:

Myofascial pain syndrome (MPS) of the cervicothoracic region is a common cause of chronic neck and upper back pain that often shows limited response to conservative therapies. The recently described serratus posterior superior intercostal plane block (SPSIPB) targets the fascial plane between the serratus posterior superior and intercostal muscles and may provide effective regional analgesia. However, its long-term clinical efficacy in MPS has not been systematically evaluated. This study aimed to investigate the effectiveness and safety of ultrasound-guided SPSIPB in patients with unilateral cervicothoracic MPS.

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Pulsed radiofrequency for managing lumbar facet joint-related chronic pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Boaz Samolsky Dekel
Presenting Author: Boaz Samolsky Dekel
Submitting Author: Boaz Samolsky Dekel

Description:

Low back pain (LBP) is a worldwide leading cause of disability, negatively impacting patients’ quality of life, social and health costs. Its management implies increased corticosteroid injections, opioid prescriptions, MRI use, and spinal surgery. The facet-joint impairment is a frequent pain generator of LBP. We aimed to assess the efficacy of pulsed radiofrequency (PRF) for managing lumbar facet joint-related chronic pain.

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Pain Inequities: QST and Health Metrics to Inform Precision Rehabilitation in Chronic Neck Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Carla S. Enriquez
Presenting Author: Carla S. Enriquez
Submitting Author: Carla Enriquez

Description:

Pain is a distinctly personal yet universal experience influenced by numerous factors beyond the correlate of sensory input and pathoanatomic tissue damage.1,2 On a global scale, chronic pain constitutes a prevalent and persistent global health issue, affecting approximately one in five adults worldwide.3 Pain is ubiquitous and imposes major global health burden from limitations in function and mobility, decreased quality of life, increased health care cost and lost productivity.1,2,3,4 This study explores the relationship between psychosocial factors and pain processing mechanisms, assessed through Quantitative Sensory Testing (QST), in individuals with Chronic Neck Pain (CNP).

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Influence of Age on Pain Reduction With Celecoxib in OA: Post Hoc Analyses From two RCTs

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Chris Walker
Presenting Author: Chris Walker
Submitting Author: Pramod Mallikarjuna

Description:

Osteoarthritis (OA) is strongly associated with aging, and age‑related joint changes may influence pain perception and treatment response. Understanding whether age modifies pain reduction is clinically relevant to optimize treatment strategies in an aging OA population and to support individualized, evidence‑based pain management.

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Global Perceived Effect of Multimodal Neck Rehabilitation within Chronic Nonspecific Neck Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Cid André Fidelis de Paula Gomes
Presenting Author: Cid André Fidelis de Paula Gomes
Submitting Author: Barbara Greco Miura

Description:

Chronic nonspecific neck pain (CNSNP) is a prevalent condition associated with persistent pain, disability, and reduced quality of life. The Global Perceived Effect (GPE) is a patient reported outcome reflecting overall clinical change and treatment effectiveness. A multimodal neck rehabilitation program (MNRP), combining exercise and manual therapy, is recommended for CNSNP management, however adjunct electroanalgesic and phototherapeutic modalities are commonly applied despite limited evidence on patient perceived recovery. This study aimed to assess GPE following an MNRP and to investigate whether adding transcutaneous electrical nerve stimulation (TENS), interferential current (IC), or photobiomodulation therapy (PBMT) provides additional perceived clinical benefit.

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Virtual Reality Hypnosis for Chronic Arthritis Pain: From User Experience to Randomized Trial

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: David Ogez
Presenting Author: David Ogez
Submitting Author: David Ogez

Description:

Chronic pain affects approximately one in five adults worldwide, representing a major public health challenge and a leading cause of disability and reduced quality of life (1,2). Arthritis and osteoarthritis are among the most frequent causes of chronic musculoskeletal pain and functional limitation (3). Non-pharmacological interventions such as hypnosis and virtual reality (VR) have demonstrated clinically meaningful analgesic effects in experimental and clinical settings (4–8), yet their combined use remains insufficiently studied in patients with chronic pain. This study aimed to evaluate feasibility, user experience, and clinical effects of a virtual reality–hypnosis (VRH) intervention in adults with arthritis-related chronic pain.

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Dual-task training for older adults with chronic musculoskeletal pain and frailty: a pilot RCT

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Derek King Wai YAU
Presenting Author: Derek King Wai YAU
Submitting Author: Derek King Wai YAU

Description:

Chronic musculoskeletal pain (CMP) significantly affects the ageing population, compromising physical activity, psychological well-being, cognitive function, and exacerbating frailty.(1) There is a strong association between pain severity and frailty,(2) with a high prevalence of chronic pain in frail older adults.(3)

While exercise can improve physical functions and reduce pain, cognitive impairment—often comorbid with CMP(4,5) and frailty(6)—remains largely unaddressed. This pilot randomised controlled trial (RCT) aims to investigate the effects of dual-task training (DTT), a potentially effective strategy that combines physical and cognitive training, in improving frailty and other health-related outcomes in frail older adults with CMP.

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Cortical connectivity changes following infraslow gray noise stimulation in chronic low back pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Divya Bharatkumar Adhia
Presenting Author: Divya Bharatkumar Adhia, Sobhan Mirzaee Porkoli
Submitting Author: Divya Adhia

Description:

Aberrant functional connectivity among cortical networks involved in pain processing—including salience (SN), sensorimotor (SMN), and default mode networks (DMN)—is consistently observed in chronic low back pain (CLBP).(1-7) Increased infraslow phase synchronization between these networks may reflect maladaptive integration of sensory, affective, and self-referential processes.(8-12) High-definition transcranial infraslow grey noise stimulation (HD-tIGNS) is a novel neuromodulation approach designed to perturb pathological network coupling by inducing phase desynchronization and promoting network flexibility(13-15). This pilot study aimed to determine whether a single session of HD-tIGNS alters functional connectivity between key network nodes and to evaluate its safety in people with CLBP.

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Prospective Outcome Review of Patients Receiving Lumbar Facet Joint Median Branch Blocks

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr Kevin Fai
Presenting Author: Dr Kevin Fai
Submitting Author: Kevin Fai

Description:

Lumbar facet joint pain is one of the most common conditions presenting to secondary care pain services and is consequently the most frequently performed intervention procedure. Current UK commissioning guidance supports a median branch block (MBB) pathway using local anaesthetic (LA) alone, with progression to radiofrequency denervation (RFD) if a positive response is demonstrated. Although osteoarthritis guidelines support steroid injections for chronic inflammatory pain, steroid use is not routinely incorporated into UK commissioning pathways for lumbar facet interventions.

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Pulsed Rf of supra scapular,Axillary and Lateral Pectoral nerve for shoulder pain-outcome

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: dDr Krishna Poddar
Presenting Author: Dr Krishna Poddar
Submitting Author: Krishna Poddar

Description:

Shoulder pain is 3rd most common musculoskeletal pain. The prevalence of Frozen shoulder (Adhesive Capsulitis) is 2 - 5%. Fibroproliferative tissue fibrosis and inflammatory contracture of the rotator interval, capsule, and ligaments leading to significant restriction of range of motion (typically external rotation).Here we are presenting case series of 20 cases of pulsed radiofrequency neuromodulation of 3 nerves of shoulder joint, Suprascapular, Axillary and Lateral pectoral nerves for treatment of Adhesive capsulitis.

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Therapeutic Potential of Platelet-Rich Plasma in Managing Knee Osteoarthritis: A Prospective Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr Ashok Lawange
Presenting Author: Dr Sunita Lawange
Submitting Author: Sunita Lawange

Description:

Background: The regenerative effect of PRP is primarily linked to biomolecules in platelets alpha granules alond with a controlled inflammatory phase which is essential for healing. Leukocytes contributr to this plaseby releasing both pro and anti- inflammatory factors, supporting a process known as inflammatory regeneration . Macrophase plasticity , particularly the shift from M1 to M2 phenotype is plays a key role in this transition .This prospective study aimed to assess the effectiveness and safety of MIPSIs like PRP injections in Knee Osteoarthritis.
Aims: To evaluate ans assess the effectiveness of platelet rich plama injections on outcomes of Knee Osteoarthritis

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Exercise therapy for chronic neck pain: A network meta‑analysis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Prof. Dr. Susan Armijo-Olivo
Presenting Author: Dr. Ana Izabela Sobral de Oliveira Souza
Submitting Author: Ana Izabela Oliveira-Souza

Description:

Neck pain is a common and globally impactful condition.[1] Clinical guidelines recommend conservative approaches, with exercise therapy as a central strategy.[1] Programs may include strengthening, stretching, and mobility exercises to improve function, reduce pain, and prevent recurrence.[2,3] While manual therapy, education, and medications are also used, evidence suggests structured exercise offers long-term benefits with fewer risks.[4,5] However, the optimal type, intensity, and duration of exercise remain unclear. This Network Meta-analysis (NMA) aims to determine which form of exercise, alone or in combination, is most effective for reducing pain in individuals with chronic neck pain.

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Discriminating Postural Impairments with Non-Linear Metrics from Smartphones for low back pain.

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Luis Cofre-Lizama
Presenting Author: Edith Elgueta Cancino
Submitting Author: Edith Elgueta-Cancino

Description:

Low back pain individuals are shown to have altered postural control compared to healthy individuals, yet traditional kinematic analyses have shown limited habiliy to distinguish between healthy and LBP populations. The complexity of postural sway can be quantified using nonlinear measures. Non-linear measures can discriminate healthy controls from pathological people (eg, multiple sclerosis) at an early stage, although linear measures cannot. Mobile phone sensors have demonstrated reliability comparable to laboratory-based motion capture systems. By combining mobile sensor data and non-linear movement analysis we aim to develop an accessible, low-cost tool for early identification of LBP risk.

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Predictors factors of physiotherapy success in chronic neck pain: A Systematic Review

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Susan Armijo-Olivo
Presenting Author: Ester Moreira de Castro-Carletti
Submitting Author: Ester Castro Carletti

Description:

Neck pain (NP) is a huge problem in modern industrialized countries, around 54% of the population is affected, from those a further 5% suffer from severe pain (1). Predictive factors of treatment success can inform the development of effective, personalized therapy, thereby improving decision-making (2). As far of the authors’ knowledge, there is no systematic review (SR) published that cover prediction analysis for adult patients with neck pain. Consequently, the aim of this SR is to compile, assess, and synthesize the available evidence about predictive factors for treatment success for patients with chronic non-specific neck pain after physical therapy treatment.

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Integration of Visio-Vestibular Exercises with Manual Therapy and Stabilization in Chronic Neck Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Derya OZER KAYA
Presenting Author: FARUK TANIK
Submitting Author: Faruk TANIK

Description:

Chronic neck pain (CNP) involves sensorimotor dysfunction affecting cervical, visual, and vestibular integration. This study aimed to investigate whether adding visio-vestibular exercises (VVE) to manual therapy and stabilization (MtE) improves pressure pain thresholds (PPT), cervical range of motion (ROM), and health-related quality of life (HRQoL) in CNP patients.

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PainPal+: Leveraging personalized mHealth to Improve Outcomes in Chronic Pain Management

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Su-Yin Yang
Presenting Author: Fong-Ling Loy
Submitting Author: Fong-Ling Loy

Description:

Chronic pain affects 27.5% of adults, with 10% newly diagnosed annually [1, 2]. Despite its widespread impact,
chronic pain remains notoriously difficult to manage, particularly outside of clinical settings where ongoing support
is often lacking. While non-pharmacological treatments like Cognitive Behavioural Therapy (CBT) show promise,
access is limited [2]. Many mHealth apps fill this gap but lack clinical validation [4, 3, 2]. PainPal+ addresses this via
AI-powered tracking and chatbot support. Study aims: To evaluate PainPal+’s (1) utility in delivering algorithm-
driven self-management suggestions and (2) AI chatbot effectiveness in supporting behavior change and
symptom tracking.

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Structural Factors and Referral Pathways Shaping Access to Interdisciplinary Pediatric Pain Care

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Amanda Stone
Presenting Author: Gloria Han
Submitting Author: Gloria Han

Description:

Interdisciplinary pediatric pain programs are geographically limited and primarily situated within specialized academic medical centers in urban settings. Access to specialty pain care is a multistage process shaped by referral pathways, travel burden, and pre-treatment healthcare exposure. Delayed or fragmented access may contribute to higher healthcare utilization and subspecialty-driven care, with pharmacologic or procedural escalation occurring before receipt of coordinated biopsychosocial intervention. This study descriptively characterizes geographic distance, referral source patterns, and pre-clinic treatment exposure among youth evaluated in an interdisciplinary pain clinic to better understand structural factors influencing access and engagement in evidence-based interdisciplinary care.

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Effect of Pain Science Education and Exercise on Disability in Older Adults with Knee Osteoarthritis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Gustavo Torres R.
Presenting Author: Gustavo Torres R.
Submitting Author: Gustavo Torres

Description:

Introduction: Osteoarthritis is a degenerative joint disease that causes pain and stiffness, being prevalent in older adults. Knee osteoarthritis is one of the main causes of chronic pain and disability, significantly affecting quality of life. Pain neuroscience education (PNE) has emerged as a promising therapeutic approach, although evidence of its benefits in knee osteoarthritis is still lacking.
Objective: To determine whether a physical exercise program combined with PNE is more effective in reducing disability in people with knee osteoarthritis compared to an exercise-only program.

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Effects of Facet Nerve Blocks on Pain, HRQoL, Disability, and Cost-Effectiveness Across Age Groups

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: hannu heikkilä
Presenting Author: hannu heikkilä
Submitting Author: hannu heikkilä

Description:

Low back pain is a common symptom, estimated to affect up to 80% of individuals at some point in their lives, and causing significant disability.
Needle-based interventions are commonly used for low-back pain treatment and interventions of the facet (zygapophyseal) joints are the second most common procedure in interventional pain medicine. The present study examined effects of Facet-Nerve Blocks on back pain in different age groups
We also studied changes in the Quality of Life (EQ5D), functioning (Oswestry disability index) and treatment costs in means of QALY

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Equal pain rehabilitation: Are sociodemographic factors associated with treatment effects?

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Anna Grimby Ekman
Presenting Author: Helene Svensdotter
Submitting Author: Helene Svensdotter

Description:

Chronic pain is a complex public health issue affecting about 20% of the European population (1). In Swedish tertiary care, interdisciplinary pain rehabilitation programs (IPRPs) are commonly used (2). The Swedish legislation states that healthcare should be provided on equal terms with need as a strong principle (3). There is a knowledge gap regarding the impact of sociodemographic factors on treatment effects after IPRP. Increased knowledge is important for equal and knowledge-based care.
The aim is to investigate if sociodemographic factors (gender, age, education level, birth region), and their combinations, are associated with treatment effects after IPRP in tertiary care.

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Characterising Validating and Invalidating Clinician Behaviours in Chronic Pain Consultations

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Hollie Birkinshaw
Presenting Author: Hollie Birkinshaw
Submitting Author: Hollie Birkinshaw

Description:

Effective clinician-patient communication is critical in chronic pain, where symptoms are complex and subjective. As communication underpins pain assessment and treatment planning, specific clinician behaviours can shape patient outcomes. Specifically, clinician validation can strengthen trust and enhance engagement with treatment, whereas invalidation may heighten distress and contribute to poorer health outcomes. However no large‑scale analysis has comprehensively characterised patient experiences of validating and invalidating clinician behaviours in pain consultations. This study therefore aimed to identify these perceived behaviours and to examine how such experiences differ across gender and age groups.

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Stress Biomarker Trajectories Linked to Pain Vulnerability in Randomised Chiropractic Trials

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Imran Khan Niazi
Presenting Author: Imran Amjad
Submitting Author: IMRAN AMJAD

Description:

Psychological and physiological stress contribute to pain vulnerability and chronification via shared neuroendocrine and autonomic mechanisms. Dysregulation of the hypothalamic–pituitary–adrenal axis and heightened stress responses are associated with increased pain sensitivity and poorer pain outcomes. Understanding how clinical interventions influence stress-related biomarkers in subclinical populations may provide insights into early pain risk and prevention.
The objective of the study was to characterise trajectories and predictors of psychological and physiological stress outcomes over 12 weeks in two randomised controlled trials (RCTs) of chiropractic care in adults and children with subclinical spinal pain, and to identify baseline and clinical factors influencing trajectories.

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Pain, Body Composition, and Epigenetic Aging Are Linked to Brain Aging Longitudinally

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Yenisel Cruz-Almeida, MSPH, PhD
Presenting Author: Javier A. Tamargo, PhD
Submitting Author: Javier Tamargo

Description:

Chronic pain, excess adiposity, and epigenetic aging are highly intertwined and have each been linked to adverse neurobiological changes. Neuroimaging-derived brain age predictors provide quantitative indicators of neurobiological aging. We examined longitudinal interrelationships among chronic pain, body mass index (BMI), epigenetic aging, and brain aging in middle-aged and older adults with and without knee osteoarthritis.

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Advancing rural MSK care: Co-designing a clinical treatment pathway for improved outcomes

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Professor Trudy Rebbeck
Presenting Author: Jemma Mulligan
Submitting Author: Jemma Mulligan

Description:

People with chronic musculoskeletal (MSK) conditions in rural Australia experience approximately 25% greater disease burden than those in metropolitan areas. Geographic isolation and limited access to appropriate services contribute to inequities in care, increasing reliance on low-value, costly interventions such as unnecessary imaging, injections, opioids and surgery. Access to specialist physiotherapy remains limited outside major cities, highlighting the need for innovative service models. Telehealth offers a scalable solution by connecting rural clinicians with expert allied health (AH) support. This study co-designs implementation strategies with rural clinicians to deliver PACE-RURAL and improve equitable MSK outcomes.

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Randomized controlled trial assessing digital gamified pain management for adults with chronic pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Jiafan He
Presenting Author: Jiafan He
Submitting Author: Jiafan He

Description:

Chronic pain is a leading cause of disability worldwide. While digital interventions offer accessible and cost-effective management, their efficacy is often limited by low engagement and adherence. Gamification, which applies game-design principles to non-game contexts, presents a promising strategy to enhance user motivation and therapeutic outcomes. This randomized controlled trial (RCT) evaluated the feasibility and preliminary effectiveness of a Gamified Pain Management (GPM) program for individuals with chronic pain.

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Three-in-One Puncture Technique for Genicular Nerve Ablation in Knee Osteoarthritis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: yulan li
Presenting Author: jinyu lai
Submitting Author: jinyu lai

Description:

Knee joint radiofrequency ablation is a commonly used intervention for patients with degenerative knee diseases and postoperative pain. Conventional approaches targeting the superior medial genicular nerve (SMGN), superior lateral genicular nerve (SLGN), and medial intermediate genicular nerve (IMGN) have demonstrated favourable outcomes. This conservative treatment strategy may reduce the overall efficacy of knee joint RFA. Our research team has developed an innovative three-in-one puncture technique for the knee, which has shown preliminarily promising results in patients with knee osteoarthritis (OA), including longer-lasting analgesia and an improved safety profile, suggesting its potential as a new standard puncture procedure for knee OA.

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Unmasking Acute Neurotoxicity During Pain Management of Lumbar Radiculopathy: A Case Report

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr. Lyde M. Alday-Magpantay, MD, MSc, DPBPM
Presenting Author: Jo Mari Darvin C. Adorador, MD, DPBA
Submitting Author: Jo Mari Darvin Adorador

Description:

Chronic lumbar radiculopathy is a common cause of morbidity often requiring multimodal analgesia. However, multi-analgesic therapy involving serotonergic opioids, corticosteroids, and gabapentinoids presents significant neurotoxic risks, particularly in patients with susceptible pharmacogenomic profiles. This case report aims to describe a patient with chronic lumbar radiculopathy who developed acute neurologic deterioration while receiving therapeutic-dose tramadol in combination with pregabalin and dexamethasone. The clinical presentation raised suspicion for altered CYP2D6 activity.

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A Case Report Describing the Use of the Butterfly as a Movement Marker of Dystonic Cervical Motions

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Marlon L. Wong, PhD - University of Miami, Miller School of Medicine, APReCIAT Laboratory
Presenting Author: Juan P. Gonzalez, DPT - University of Miami, Miller School of Medicine, APReCIAT Laboratory
Submitting Author: Juan Gonzalez

Description:

Idiopathic cervical dystonia (iCD) is characterized by sustained or intermittent neck movements caused by involuntary muscle contractions, resulting in abnormal movements and postures of head, neck, and/or shoulders. Currently, diagnostic approaches are based on clinical expert opinion and there is a lack of objective sensory motor tools to assess dystonic movements. The purpose of this case report is to describe the integration of the butterfly (FLY) assessment as a marker of dystonic movements.

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Physical & Psychological Predictors of Persistent/Recurrent LBP: Systematic Review & Meta-Analysis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Deborah Falla
Presenting Author: Kanya Wongwitwichote
Submitting Author: Kanya Wongwitwichote

Description:

While most cases of low back pain (LBP) resolve naturally, approximately one-third develop persistent or recurrent LBP (1), leading to substantial disability (2). Physical and psychological impairments may be important risk factors for developing persistent or recurrent LBP (3, 4), impacting quality of life and creating a burden on individuals and healthcare systems (5). However, the predictive value of specific physical and psychological factors remains unclear. This systematic review aimed to evaluate whether physical and psychological factors predict persistent or recurrent non-specific LBP.

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Paracetamol demonstrates efficacy comparable to celecoxib in patients with chronic low back pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Kazuhiro Hayashi
Presenting Author: Kazuhiro Hayashi
Submitting Author: Kazuhiro Hayashi

Description:

Pharmacological treatment is commonly used for patients with chronic low back pain (CLBP). However, despite its widespread use, the evidence supporting paracetamol as a treatment option for CLBP remains of low quality, leading to contradictory recommendations across guidelines. A nonrandomized observational study suggested that paracetamol has analgesic effects comparable to nonsteroidal anti-inflammatory drugs in patients with CLBP. Therefore, this randomized controlled study aimed to compare the analgesic effects of paracetamol and celecoxib in a non-inferiority trial. This non-inferiority trial tested the hypothesis that paracetamol is as effective as celecoxib for the treatment of CLBP within a pre-specified non-inferiority margin.

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Association of Chronic Joint Pain With Incident Cognitive Impairment in a US Population-Based Cohort

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Felipe Fregni
Presenting Author: Kevin Pacheco-Barrios
Submitting Author: Kevin Pacheco-Barrios

Description:

Chronic joint pain is highly prevalent worldwide and may contribute to cognitive vulnerability in aging, yet longitudinal population-based evidence is limited. Identifying behavioral and psychological pathways may reveal modifiable targets for dementia prevention. This study aims to evaluate the association between chronic joint pain and incident cognitive impairment and to examine behavioral and affective moderators and mediators of this relationship. This is a population-based cohort study using data from the Health and Retirement Study (HRS), a nationally representative longitudinal study of US adults aged ≥50 years.

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Treatment Expectation and Associations with Baseline Characteristics in a Randomized Trial

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Asger Reinstrup Bihlet
Presenting Author: Kristian Kjær-Staal Petersen
Submitting Author: Jakob Bentin

Description:

Identifying novel analgesics has become increasingly challenging [1], and improved understanding of the placebo response (PR) may enhance drug development. Contextual effects account for up to 75% of pain reduction in osteoarthritis (OA) trials [2], and the PR has increased in neuropathic pain trials [3]. Mechanistic studies highlight cognitive and emotional factors, particularly patient expectations, as key mediators of PR [1,4–8]. Expectations can be assessed by directly asking participants about perceived treatment allocation or anticipated benefit [1,4,5,9,10]. This study examined associations between baseline characteristics and baseline expectations of treatment effect in a randomized controlled trial.

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Readiness to Change Profiles in Chronic Low Back Pain Using the Pain Stages of Change Questionnaire

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Thais Cristina Chaves
Presenting Author: Laís Braga Agostinho
Submitting Author: Laís Agostinho

Description:

Readiness for change is an important construct for understanding engagement in self-management behaviors in chronic low back pain (CLBP) (Kerns et al., 2005). This construct suggests that individuals go through different motivational stages throughout behavioral change, which may vary among themselves (Kerns et al., 1997). Some studies indicate that patients can be classified into subgroups based on their readiness for change profiles, which may be associated with clinically relevant differences (Kerns et al., 2005). The subgroups vary in pre-contemplation, contemplation, action, and maintenance. However, this heterogeneity is often overlooked when using simplified approaches (Jensen et al., 2000). The PSOCQ is a multidimensional measure developed to assess readiness to adopt a self-management approach to pain (Carr et al., 2006). Therefore, this study aimed to identify subgroups of individuals with chronic low back pain (CLBP) based on PSOCQ response profiles and to examine these varied subgroups in clinically relevant depth.

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A Five-Domain Clinical Screen Identifies High-Risk Disability in Chronic Low Back Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Le Thi Cuc
Presenting Author: Le Thi Cuc
Submitting Author: Thi Cuc Le

Description:

In chronic low back pain (CLBP), disability is commonly approached through pain intensity alone, despite frequent co-occurrence of fear of movement and emotional distress symptoms. Aim: We examined whether a cumulative five-domain symptom-burden phenotype (pain, kinesiophobia, depression-, anxiety-, and stress-symptom domains) stratifies disability severity, and whether pain influences disability directly and indirectly via kinesiophobia and distress symptoms. We hypothesized a graded dose–response relationship between burden and disability, and a fear-mediated pathway from pain to disability.

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PILATES REDUCES PAIN AND IMPROVES FUNCTIONAL CAPACITY IN INDIVIDUALS WITH RHEUMATIC CONDITIONS

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Liane Macedo
Presenting Author: Liane Macedo
Submitting Author: Liane Macedo

Description:

Rheumatic conditions are a group of diseases that can cause inflammation, changes in the joints, and pain in surrounding structures, and the Pilates method has been used as a tool in the rehabilitation of these patients.The aim of this study is to evaluate the effectiveness of the Pilates method in individuals with rheumatic conditions.

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THE ASSOCIATION OF MOVEMENT-EVOKED PAIN WITH COGNITIVE / EMOTIONAL FACTORS: A CROSS-SECTIONAL STUDY

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Lisa Carlesso
Presenting Author: Lisa Carlesso
Submitting Author: Lisa Carlesso

Description:

Movement-evoked pain (MEP) is a key feature of knee osteoarthritis (KOA) that often results in limited physical activity and reduced quality of life. Despite its clinical relevance, MEP is a relatively new construct, resulting in sparse and heterogenous knowledge in assessing the influence of individual psychological factors on MEP intensity. An individual’s pattern of physical (in)activity may be affected by MEP, along with associated thoughts and feelings of their painful movements. However, this relationship remains under-researched. Therefore, the aim of this study is to determine (a) the association and explained variances of situational catastrophizing, knee confidence, and fear of movement with MEP and (b) whether associations differ based on the perceived threat of the task.

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Exercise prescription for chronic neck pain: a narrative synthesis of a systematic review

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Susan Armijo-Olivo
Presenting Author: Luiz Felipe Tavares
Submitting Author: Luiz Felipe Tavares

Description:

Chronic neck pain (CNP) is a prevalent condition often associated with persistent pain, disability, and reduced quality of life. Physical activity is recommended as core component for managing chronic pain; However, most research focuses on supervised, on-site exercises, with limited attention to the impact of exercise prescription alone. Prescription of physical activity (PPA) represents a clinical strategy that may influence outcomes while improving care. Currently, no systematic reviews have specifically examined how exercise is prescribed or how prescription-based interventions differ from supervised delivery. This review aimed to synthesize exercise prescription characteristics in trials involving individuals with CNP.

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From Periphery to Brain: The Relation of Sensitization and Resting-State Functional Connectivity

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Petra Schweinhardt
Presenting Author: Madeleine Hau
Submitting Author: Madeleine Hau

Description:

Sensitization on peripheral, spinal and supraspinal levels ought to be reflected in different proxy measures. Hypersensitivity in the patient's most painful region (MP) likely indicates peripheral sensitization and hypersensitivity in a pain-free, adjacent area (AD) spinal sensitization. Hypersensitivity in a remote, pain-free site (CON) or pain catastrophizing (PCS), conceivably involves supraspinal circuits [1,4,5]. While supraspinal sensitization is associated with resting-state functional connectivity (rsFC) [3], it remains unclear if such a relation exists for peripheral or spinal sensitization. This study investigated relations between indicators of peripheral, spinal and supraspinal sensitization, respectively, and rsFC in chronic low back pain (cLBP) patients.

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Multicenter trial of mHealth versus booklet for chronic low back pain: Preliminary results

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Rodrigo Luiz Carregaro
Presenting Author: Maria Augusta de Araújo Mota
Submitting Author: Maria Augusta de Araújo Mota

Description:

Chronic non-specific low back pain (CNLBP) is a leading cause of disability worldwide, generating a substantial clinical and economic burden. Digital health strategies could improve the scalability and personalisation of exercise-based interventions by integrating pain education and neurocognitive approaches. This study presents preliminary findings from an ongoing multicentre randomised controlled trial with an economic evaluation, which compares a supervised mobile health intervention with a conventional exercise booklet. The objective was to explore the short-term (8-week) effects on pain and disability, and to examine whether prognostic risk factors at baseline influence the early response to treatment.

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Treatment effect modifiers of graded sensorimotor retraining for people with chronic low back pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Aidan G Cashin
Presenting Author: Martjie Venter
Submitting Author: Martjie Venter

Description:

Outcomes of low back pain management may be improved through targeting treatments to patient subgroups who share characteristics. Graded sensorimotor retraining is a theoretically informed treatment (1) for chronic low back pain, which demonstrated clinically meaningful and sustained improvements in pain intensity and disability in a sham-controlled randomised trial. (2) Variables that modify the effect of graded sensorimotor retraining need investigation to facilitate optimization and implementation of this treatment for people with chronic low back pain. (3) This study aims to investigate potential treatment effect modifiers of graded sensorimotor retraining on pain intensity and disability in the short and long-term.

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Biopsychosocial factors may explain shoulder pain and disability in chronic shoulder pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Paula Rezende Camargo
Presenting Author: Matheus Dias Gregorio
Submitting Author: Matheus Dias Gregorio

Description:

Shoulder pain is one of the most prevalent musculoskeletal conditions, with pain intensity and disability being the most frequently reported complaints. Psychological factors, including catastrophizing, anxiety, depression, and low self-efficacy, have been shown to contribute to symptom persistence and poor treatment outcomes. However, evidence integrating demographic and clinical variables remain limited, resulting in a gap in understanding the biopsychosocial factors associated with shoulder pain and disability. This study determined whether the integration of sociodemographic and psychological aspects can explain shoulder pain and disability in individuals with chronic shoulder pain.

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Tuina for Chronic Low Back Pain: A Systematic Review of Effectiveness and Design

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Brent A. Bauer
Presenting Author: Michael R. Mueller
Submitting Author: TIANYI ZHAO

Description:

Chronic low back pain (CLBP) is a leading cause of disability worldwide. Tuina, a traditional Chinese manual therapy, is widely used for CLBP management, particularly in China, yet its reported effectiveness remains heterogeneous across studies. A major source of variability may lie in how Tuina interventions are defined, implemented, and reported. This systematic review aims to evaluate the effectiveness and safety of Tuina for CLBP while systematically examining how Tuina interventions are interpreted and operationalized across clinical studies and whether differences in intervention characteristics are associated with treatment outcomes.

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Association Between Chronic Musculoskeletal Pain and Cognitive Impairment

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Yun Wang
Presenting Author: Ming-Xuan Yang
Submitting Author: Ming-Xuan Yang

Description:

Chronic musculoskeletal pain is common in older adults and a major cause of disability. Although emerging evidence suggests links between chronic pain and cognitive ageing or dementia, epidemiological findings remain inconsistent and are often confounded by heterogeneous pain phenotypes and outcome definitions, limiting its integration into clinical risk assessment.

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Trajectories of Primary Healthcare Use in People with Fibromyalgia: A Latent Class Analysis in CPRD

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr Ian Scott
Presenting Author: Ms Ailish Katherine Byrne
Submitting Author: Ailish Byrne

Description:

Fibromyalgia is a common chronic, widespread pain condition, associated with higher healthcare use than the general population. Difficulty diagnosing and managing fibromyalgia often leads to ineffective or inappropriate healthcare use. Understanding how people with fibromyalgia use healthcare is crucial for service planning, yet it is unclear whether subgroups exist that follow differing patterns or trajectories of use over time. This knowledge could help inform the provision of appropriate and stratified care. This study explored the presence of distinct classes of primary healthcare use trajectories in people with newly diagnosed fibromyalgia over four years and compared their sociodemographic and comorbid characteristics.

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Brain Changes in Chronic Low Back Pain comapred to healthy controls: An fMRI Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Muhammed Rashid
Presenting Author: Muhammed Rashid
Submitting Author: Muhammed Rashid

Description:

Chronic low back pain (CLBP) is associated with persistent pain, disability, and altered central pain processing. Neuroimaging evidence suggests that long-standing pain is linked with structural and functional brain changes, particularly in regions involved in pain modulation, emotion, and motor control. However, the pattern of baseline brain alterations in CLBP compared with healthy individuals requires further clarification. Understanding these changes is important for identifying central mechanisms contributing to pain persistence. This study aimed to compare baseline structural brain measures, functional connectivity, and effective connectivity between individuals with CLBP and healthy controls using functional magnetic resonance imaging.

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Genicular Peripheral Nerve Stimulation for Chronic Post-Surgical Knee Pain: A Case Series

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Jason Petusevsky
Presenting Author: Naileshni Singh
Submitting Author: Naileshni Singh

Description:

Roughly 1 in 4 individuals in the United States experience chronic knee pain resulting in 4 million medical visits annually. The high prevalence manifests in enormous healthcare burden. Peripheral Nerve Stimulation (PNS) delivers electrical impulses to peripheral nerves to reduce pain by modulating central pathways. It is a treatment option in chronic pain patients who are not surgical candidates or who have undergone total knee arthroplasty (TKA) without success. It is a minimally invasive, surgically implanted, and reversible option associated with sustained pain relief (1). Here we present a retrospective case series of genicular nerve PNS for chronic knee pain.

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Physical Workload, Psychological Wellbeing, and Interacting Effects on Low Back Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Tiffany Gill
Presenting Author: Nasibeh Sorkhi Kojabad
Submitting Author: Nasibeh Sorkhi Kojabad

Description:

Background
Low back pain (LBP) is the leading global cause of disability and is influenced by physical, psychological, and social factors (1–4). In working‑age adults, high physical workload, adverse psychological status, and social disadvantage are each linked to greater pain and poorer outcomes (5–8). However, most studies have treated these influences as separate or merely additive, rather than examining how they cluster and interact (9–11). There remains a need for population‑based analyses that model these multidimensional domains jointly and quantify their combined impact on LBP‑related outcomes in working‑age adults.

Aim of Investigation
We aim to quantify how the physical and psychological domains interact in predicting LBP-related outcomes in a large population-based representative sample of working-age people.

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Efficacy of Integrated Yoga Therapy vs Physiotherapy in Chronic Low Back Pain in Elderly Patients

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Neerja Bharti
Presenting Author: Neerja Bharti
Submitting Author: NEERJA BHARTI

Description:

Age-related musculoskeletal degeneration, poor posture, sarcopenia, and osteoarthritis contribute to the burden of chronic low back pain in elderly population, affecting mobility and reducing their quality of life. The management of chronic back pain is also difficult in elderly as these patients are particularly susceptible to the side effects of conventional pharmacotherapy and interventions. Among non-pharmacological treatments, Physiotherapy, based on stretching and strengthening exercises, focuses primarily on physical rehabilitation, while Integrated Yoga Therapy (IYT) integrates the mind-body connection, potentially addressing both the physical and psychological dimensions of pain, offering a holistic approach to pain management. The current study was designed to compare the feasibility and efficacy of Integrated Yoga Therapy with conventional Physiotherapy in reducing pain intensity, back disability, and improving spinal flexibility in elderly patients having long standing low back pain. Serum IGF-1 levels were also compared to assess the effect of treatment on pain hypersensitivity at spinal level.

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Associations between quantitative sensory testing parameters and pain extent in low back pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Anders Hansen PhD
Presenting Author: Nils Lennart Reiter
Submitting Author: Nils Lennart Reiter

Description:

Low back pain (LBP) is a leading cause of years lived with disability worldwide (1). Previous studies indicate that patients with LBP often exhibit altered sensory thresholds in quantitative sensory testing (QST), frequently interpreted as proxies for central sensitization (2). Clinically, central sensitization is often linked to diffuse, non-anatomical, and widespread pain patterns (4). However, the relationship between markers of altered sensory processing and spatial pain extent remains unclear. This cross-sectional study examined whether QST parameters are associated with digitally quantified pain drawing area in adults with LBP and whether these associations differ across diagnostic categories.

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Development of a network for interactions among biopsychosocial dimensions of chronic low back pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Hugo Massé-Alarie and Patrick Desrosiers shared senior author
Presenting Author: Pouya Rabiei
Submitting Author: Pouya Rabiei

Description:

Network analysis describes complex interactions among features, enabling examination of system-level relationships across domains (1). Low back pain is a leading cause of disability, with approximately 40% of individuals experiencing pain longer than three months, termed chronic low back pain (CLBP) (2). Growing evidence indicates that multiple biopsychosocial factors are associated with CLBP and may interact to exacerbate its persistence (3,4). However, the nature of these interactions remains poorly understood. Here using a network analysis we aimed to uncover and characterize interrelations among biopsychosocial domains and identified the most influential features via centrality metrics in CLBP individuals.

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Research of Ultrasound-Guided Extracorporeal Shock Wave for Third Lumbar Transverse Syndrome

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: QIAO BAO GUANG
Presenting Author: QIAO BAO GUANG
Submitting Author: Qiao Bao guang

Description:

To explore the clinical efficacy of different pressure levels of extracorporeal shock wave therapy in the treatment of lateral epicondylitis of the humerus.

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Altered Sensitivity and Habituation in Chronic Pain: Sensitization and Predictive Coding Converge

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Joshua Brown
Presenting Author: Rahwa Netsanet
Submitting Author: Rahwa Netsanet

Description:

Chronic pain is increasingly conceptualized as a disorder involving central sensitization and altered predictive processing. Central sensitization reflects amplified nociceptive signaling leading to greater sensitivity to stimuli, whereas predictive models indicate a potential disruption in prediction error processing when sensory inputs deviate from expectation. These mechanisms are not mutually exclusive and may jointly contribute to altered pain perception in chronic pain. Here, we examined whether chronic pain subjects differ from healthy controls in shock sensitivity and habituation, and whether psychological vulnerability measure moderate these processes.

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Erector Spinae Plane Block As An Emerging Modality For Shoulder Pain: A Prospective Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Sandeep Kadam
Presenting Author: Rashmi N S
Submitting Author: Rashmi N S

Description:

AIM:
To evaluate the role of Erector Spinae Plane Block in the management of shoulder pain.

OBJECTIVES:
Primary

1. Assessment of pain score using Numeric Pain Rating Scale(NPRS) at 4,8and 12 weeks.
2. To evaluate the improvement of quality of life by disability score (Shoulder Pain and Disability Index=SPADI) at 4,8and 12 weeks.

Secondary

1.To evaluate complications/ adverse effect of block.
2.Analgesic Requirement.
Prevalence of shoulder pain is around 20%, significantly higher in elderly causing significant morbidity (1). It is very important to treat as it will impact the quality of life. Not all patients respond to present pain management alternatives (2). The need for newer and better alternative therapeutic technique needs consideration. Since the erector spinae plane (ESP) block has been described in the successful management of both thoracic and abdominal pain, and as it extends to the cervical spine, the ESP block may be potentially useful(3).

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Pain beliefs and coping strategies among Nepali adults with low back pain: A Qualitative Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Saurab Sharma
Presenting Author: Ritu Basnet
Submitting Author: Ritu Basnet

Description:

Background
Chronic low back pain (CLBP) is a common disabling condition. A complex set of biological, psychological and social factors contributes to CLBP and its persistence. Data from western literature show that two categories of psychological factors are considered important contributors, namely pain beliefs and pain coping responses. However, data from non-Western contexts are currently lacking, while these issues are not yet explored in individuals with CLBP in Nepal.
Aim
This study aimed to better understand pain beliefs and coping strategies among Nepali adults with CLBP.

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Is Muscle Size or Fat Infiltration the Best Indicator of Neck Pain? A Systematic Review

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Roeya Eshaghimoghaddam
Presenting Author: Roeya Eshaghimoghaddam
Submitting Author: Roeya Eshaghimoghaddam

Description:

Muscle size and fat infiltration are commonly used markers of neck pain disorders, yet it remains unclear which specific measurements and cervical muscles provide the most reliable indicators. Some studies report more pronounced changes in superficial muscles, while others highlight alterations in deep cervical muscles. These inconsistencies may arise from differences in measurement techniques. For example, cross-sectional area (CSA) does not fully capture three-dimensional muscle morphology or the spatial distribution of fat, which can be assessed through volume measurements. This review aimed to determine which measurements, and which specific cervical muscles provide the most robust indicators of neck pain disorders.

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Baseline Characteristics of Older Adults with Chronic Pain and Early Cognitive Decline

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Ana-Maria Vranceanu
Presenting Author: Ryan Mace
Submitting Author: Defne Yucebas

Description:

Chronic pain (CP) and early cognitive decline (ECD) frequently co-occur in older adults and exacerbate physical, emotional, and cognitive impairment, increasing risk for Alzheimer’s disease and related dementias. Evidence indicates a bidirectional relationship, whereby chronic pain accelerates cognitive decline, and cognitive impairment amplifies pain, maladaptive responses, and functional limitation. Despite these risks, empirical data describing older adults with CP and ECD who enroll in behavioral trials remain limited. Poor characterization constrains recruitment, intervention tailoring, and interpretation of treatment outcomes. This study describes baseline demographic, clinical, and psychosocial characteristics of this vulnerable population to inform future behavioral interventions and clinical trials.

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The Efficacy of Repeat Medial Branch Radiofrequency Ablation

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Nalini Sehgal, MD
Presenting Author: Samantha Kultgen, MD
Submitting Author: Samantha Kultgen

Description:

Facet joints, or zygapophyseal joints, are a common source of persistent spinal pain in 15 to 45% of chronic low back pain patients, 36 to 60% of chronic neck pain patients, and 34 to 48% of thoracic pain patients [1]. Facet joints are innervated by the medial branches of the dorsal rami. Radiofrequency ablation (RFA) of these medial branches is one option for management of facet mediated pain. This study aims to characterize the efficacy of repeated medial branch RFA procedures along with the maximum number of RFA procedures performed at the cervical, thoracic, and lumbar levels.

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Is Pain Relief Metabolically Limited? Prospective Outcomes of Lumbar TFESI in Metabolic Syndrome

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Savas Sencan
Presenting Author: Savas Sencan
Submitting Author: Merve Sekizkardes Tutuncu

Description:

Metabolic syndrome (MS)—defined by central obesity, dyslipidemia, hypertension, and impaired glucose metabolism—has been increasingly linked to chronic pain through systemic inflammatory activity and biomechanical pathways. Despite this relevance, its influence on the clinical effectiveness of lumbar transforaminal epidural steroid injections (TFESI) has not been prospectively evaluated. This study aimed to determine whether metabolic syndrome affects overall treatment success following lumbar TFESI.

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Sonographic Phenotyping & Protocol-Based Interventions in Knee Osteoarthritis - Retrospective Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: SENTHIL PRAKASH MOHAN
Presenting Author: SENTHIL PRAKASH MOHAN
Submitting Author: SENTHIL PRAKASH MOHAN

Description:

Knee osteoarthritis exhibits marked pathophysiological heterogeneity; yet interventional practice continues to apply uniform treatment algorithms irrespective of disease subtype, yielding inconsistent analgesic and functional outcomes.2 Sonographic phenotyping1 has emerged as a clinically accessible stratification tool capable of rationalising therapy selection at the point of care. We hypothesised that a standardised four-view musculoskeletal ultrasound protocol — capturing synovial, cartilage, biomechanical, and metabolic domains — could reliably classify patients into inflammatory, structural, or mixed phenotypes, and that phenotype-directed protocols would deliver superior outcomes.1,3 This study evaluates the clinical efficacy of a novel sonographic triage algorithm deploying cartilage-sparing lavage and oxidative modulation 4,5, orthobiologics6, and cooled neuromodulation7 according to the dominant phenotype.

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Associations of Pain Resilience with Disability, Sleep, Anxiety and Depression in Low Back Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Sevinc Akdeniz
Presenting Author: Sevinc Akdeniz
Submitting Author: Sevinc Akdeniz

Description:

Low back pain is highly prevalent in the general population and a leading cause of disability worldwide (1). Pain resilience may be an important factor influencing pain-related outcomes, yet its association with clinical and psychosocial variables remains insufficiently understood. This study aimed to investigate the associations between the biopsychological pain resilience core and pain, disability, sleep quality, anxiety, and depression in individuals with chronic low back pain.

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EFFECTIVENESS OF PLATELET RICH PLASMA VERSUS CORTICOSTEROID IN THE TREATMENT OF PLANTAR FASCIITIS

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: SHUKHA RANJAN DAS
Presenting Author: SHUKHA RANJAN DAS
Submitting Author: Shukha Ranjan Das

Description:

Background: Plantar fasciitis is a common cause of heel pain. Corticosteroid is used for planter fasciitis but provides only short-term pain relief with disappointing long-term results. This procedure is also associated with complications, including localized infection, fat pad atrophy, and plantar fascia rupture. In recent years, platelet-rich plasma (PRP) has been investigated as a treatment option for plantar fasciitis.

Aims : To evaluate the effectiveness of platelet rich plasma versus corticosteroid in the treatment of plantar fasciitis.

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Resting-state EEG correlates of attentional bias to pain-related information in chronic back pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Divya Bharatkumar Adhia
Presenting Author: Divya Adhia
Submitting Author: Divya Adhia

Description:

Attention bias towards pain-related information is mediated by intrinsic brain states which are altered in people with chronic pain.(1-3) While task-based studies demonstrate altered neural responses to pain-related stimuli (4-6), it remains unclear whether attentional bias is linked to intrinsic brain states. This study examined whether resting-state electroencephalography (EEG) features are associated with attentional bias to pain-related sensory interference, as measured by a Stroop interference task.

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Chronic Pain and Processing Speed Link Poor Sleep to Slower Gait Speed in Older Adults

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Yenisel Cruz-Almeida
Presenting Author: Soamy Montesino Goicolea
Submitting Author: Soamy Montesino Goicolea

Description:

Sleep disturbance and slower gait are each associated with disability in older adults, yet the variables that account for their association are poorly characterized. Poor sleep is linked to greater clinical pain, and greater pain co-occurs with slower gait—suggesting that pain may statistically account for the sleep–gait association. Additionally, chronic pain is associated with reduced processing speed, which independently predicts gait velocity in aging. Using cross-sectional mediation analysis, we tested whether pain accounts for the sleep–gait association and whether cognitive function further explains it in a serial model: Sleep→Pain→Cognition→Gait.

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The AsCent pain risk stratification tool: healthcare professionals’ and researchers’ perspectives

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Stephanie L. Smith
Presenting Author: Stephanie L. Smith
Submitting Author: Georgia Clay

Description:

Pain is commonly experienced in individuals with musculoskeletal conditions. The central nervous system (CNS), and particularly dysfunctional CNS processing, is thought to play a key role in understanding pain in these conditions. Current assessment methods of dysfunctional CNS processing are not feasible in clinical settings. The Assessing Central Aspects of Pain (AsCent) study aims to combine clinical quantitative sensory testing with the Central Aspects of Pain Questionnaire to create a novel risk stratification tool to identify people at risk of persistent or worsening pain likely due to dysfunction within the CNS. The aim of this study was to qualitatively explore the perceptions of healthcare professionals (HCPs) and researchers working in chronic musculoskeletal pain about the perceived utility, feasibility and acceptability of the AsCent risk stratification tool.

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Morphometric analysis of brain structures in patients with chronic cervical pain syndrome

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Stojanov Aleksandar
Presenting Author: Stojanov Aleksandar
Submitting Author: ALEKSANDAR STOJANOV

Description:

A reduction in gray matter volume is common in patients with chronic back pain, and different types of pain are associated with gray matter abnormalities in distinct brain regions. The objective is to examine differences in brain morphology in patients with cervical back pain. We investigated changes in gray matter volume using voxel-based morphometry.

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Comparison of the Effects of VR Simulation Before Lumbar Transforaminal Epidural Steroid Injections

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Jae Chul Koh
Presenting Author: Sunmin Kim
Submitting Author: Sunmin Kim

Description:

Lumbar Transforaminal Epidural Steroid Injection (TFESI) can be challenging due to anatomical variations, posing risks, especially for novices. While virtual reality (VR) simulation is emerging, research on using patient-specific data for pre-procedural TFESI practice remains limited. We evaluated the effect of patient-specific 3D VR simulation on challenging lumbar TFESI performance.

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Pain Responses in Temporomandibular Disorders Are Better Described by Effort in a Bruxism Model

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Paulo César Rodrigues Conti
Presenting Author: Tatiana Prosini da Fonte
Submitting Author: Tatiana da Fonte

Description:

Sleep bruxism is commonly quantified by the number of electromyographic events; however, event counts may not adequately represent cumulative muscular load or the clinical impact of repetitive jaw activity. Experimental tolerance tests and non-standardized clenching tasks have improved understanding of muscle pain mechanisms but often fail to reproduce the intermittent, rhythmic, and load-dependent characteristics of bruxism activity. Based on polysomnographic definitions of rhythmic (phasic) and sustained (tonic) activity, this study investigated discomfort and pain responses in women with and without temporomandibular disorders (TMD) using a standardized intermittent clenching model designed to approximate clinically relevant bruxism-related mandibular loading.

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Responsiveness of Pain Concept Instruments in Patients with Chronic Low Back Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Thais Cristina Chaves
Presenting Author: Thamiris Costa de Lima
Submitting Author: Thamiris Costa de Lima

Description:

Pain Science Education (PSE) aims to align individuals’ understanding of pain with current science, improving pain and wellbeing [1]. PSE focuses on conceptual change by restructuring existing knowledge and addressing misconceptions [2]. The Concept of Pain Inventory (COPI-Adult) [3] and Pain Concepts Questionnaire (PCQ) [4] are patient-reported measures that assess beliefs about pain, but their responsiveness, ability to detect changes over time in the construct being measured, has not been studied [5]. This study investigates the responsiveness of COPI-Adult and PCQ in patients with chronic low back pain (CLBP) following a PSE program.

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Clinical Variables Outperform MEPs in Predicting Motor Recovery After Spinal Cord Injury

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Wing P. Chan
Presenting Author: Vu Pham Thao Vy
Submitting Author: Pham Thao Vy Vu

Description:

Accurate early prediction of motor recovery after spinal cord injury (SCI) is essential for prognosis and rehabilitation planning. While motor-evoked potentials (MEP) have been proposed as objective biomarkers, their added value beyond clinical assessment remains uncertain.
To evaluate the predictive performance of clinical and MEP-derived variables for short-term motor recovery in patients with SCI.

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Risk Factors for Pain Recurrence After Percutaneous Transforaminal Endoscopic Discectomy

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Xin Yuan
Presenting Author: Xin Yuan
Submitting Author: Xin Yuan

Description:

Percutaneous transforaminal endoscopic discectomy (PTED) is a common minimally invasive treatment for lumbar disc herniation (LDH) in pain medicine, but pain recurrence affects prognosis. This study explores its risk factors and proposes targeted interventional strategies.

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Efficacy and Safety: Autologous PRP+MT in Scapulohumeral Periarthritis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Yinghao Ou
Presenting Author: Yinghao Ou
Submitting Author: Yinghao Ou

Description:

Objective:
To investigate the efficacy and safety of autologous platelet-rich plasma (PRP) combined with manual therapy in the treatment of scapulohumeral periarthritis.

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Application of Ultrasound-Guided Muscle Trigger Points in Chronic Musculoskeletal Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Yongjun Zheng
Presenting Author: Yongjun Zheng
Submitting Author: Yongjun Zheng

Description:

Chronic musculoskeletal pain is frequently associated with myofascial trigger points (MTrPs), which may contribute to localized and referred pain, movement restriction, and functional limitation. Ultrasound guidance can improve the accuracy and safety of trigger point interventions by visualizing target muscles and adjacent neurovascular structures. This study aims to summarize the potential clinical value of ultrasound-guided trigger point procedures for chronic musculoskeletal pain management.

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Chronic Low Back Pain Management: Clinical and Psychophysiological Outcomes of Yoga and Mindfulness

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Sadaf Ahmed
Presenting Author: Yusra Saleem
Submitting Author: Yusra Saleem

Description:

Chronic low back pain (CLBP) is a widespread medical issue that impacts personal health and generates substantial economic costs. Traditional treatment methods often show limited efficacy, leading to a search for alternative therapies such as yoga and mindfulness-based stress reduction (MBSR). This study aims to compare the efficacy of Sphinx pose yoga and MBSR in managing CLBP in healthcare providers.

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Prevalence of low back pain in the general population of Latin American countries. Systematic review

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Judith Bosmans
Presenting Author: Rodrigo Luiz Carregaro
Submitting Author: Rodrigo Luiz Carregaro

Description:

Low back pain is a leading cause of disability worldwide, particularly in low- and middle-income countries (LMICs), where robust, population-level prevalence data is scarce and health systems are under strain due to competing priorities. In Brazil, for example, low back pain generates substantial healthcare expenditure and productivity losses. Summarising prevalence estimates from population-based studies in Latin American LMICs could offer valuable insights for health policy, such as burden estimation, resource prioritisation and the integration of low back pain into non-communicable disease strategies. This study aimed to summarise low back pain prevalence in Brazil and other Latin American countries.

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How Trustworthy Are Network Meta-Analyses of Treatments for Painful Temporomandibular Disorders?

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Carolina B. Meloto
Presenting Author: Ahmad G.A. Khater
Submitting Author: Ahmad Khater

Description:

Painful temporomandibular disorders (PTMDs) are among the most common chronic pain conditions, contributing substantially to disability, reduced quality of life, and healthcare costs. Existing interventions span conservative, pharmacological, and surgical interventions. Despite the interventions’ availability, several uncertainties remain about these interventions' effectiveness. Properly presenting evidence is essential to prevent the misuse of research findings and to ensure that research evidence effectively reaches relevant stakeholders. Therefore, this is the first study to assess whether existing systematic reviews (SRs) with network meta-analyses (NMAs) of treatments for PTMDs provide trustworthy clinical conclusions through structured evidence summaries and how NMA findings were presented.

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Acute Virtual Reality Analgesic Response Predicts Long-Term Chronic Pain Outcomes

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Luana Colloca
Presenting Author: Anna Han
Submitting Author: Anna Han

Description:

Virtual reality (VR) has been increasingly adopted as a non-pharmacological intervention for chronic pain. An early neuroimaging study suggested that VR-induced analgesia involves brain regions overlapping with those engaged in opioid-mediated pain modulation [1]. In addition, VR appears to enhance conditioned pain modulation (CPM) efficacy [2]. These findings suggest that VR-induced analgesia engages endogenous pain modulatory systems. Accordingly, we hypothesize that individual variability in VR responsiveness reflects the capacity of endogenous pain modulation. If so, responsiveness to a single VR session may predict longitudinal pain trajectories assessed via ecological momentary assessment (EMA) [3].

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Electrophysiological Evidence of Systemic Neural Hyperexcitability in Primary Trigeminal Neuralgia

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: andrea truini
Presenting Author: andrea truini
Submitting Author: Caterina Maria Leone

Description:

Background: Primary trigeminal neuralgia (TN) is a representative neuropathic facial pain disorder and is classified into classical TN, associated with neurovascular compression, and idiopathic TN, in which no clear etiology is identified. Increasing evidence, including the identification of pathogenic genetic variants within the sensory electrogenisome, supports a multifactorial pathophysiology that converges on neuronal hyperexcitability, which may extend beyond the trigeminal nerve, reflecting a more generalized axonal predisposition.
Objective: To investigate whether patients with trigeminal neuralgia exhibit generalized axonal hyperexcitability detectable in peripheral motor nerves, and to assess the influence of sodium channel–blocking therapy on axonal excitability parameters.

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Percutaneous Intervention: A Boon for for trigeminal neuralgia due to Vertebrobasilar dolicoectasia

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr Jyeshtharaj Vidyasagar Patangankar
Presenting Author: Dr Jyeshtharaj Vidyasagar Patangankar
Submitting Author: Jyeshtharaj Patangankar

Description:

Trigeminal neuralgia (TN) secondary to vertebrobasilar dolichoectasia (VBD) is a rare but challenging clinical entity caused by ectatic and tortuous vertebrobasilar arteries compressing the trigeminal nerve root entry zone. Management is often difficult due to patient comorbidities and the complex vascular anatomy, limiting the feasibility of microvascular decompression.

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Biopsychosocial phenotypes of TMD reveal distinct clinical profiles unrelated to cortisol imbalance

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Mariana Lima Vale
Presenting Author: Erika Brasil Cavalcante Citó
Submitting Author: Erika Citó

Description:

Temporomandibular disorder (TMD) is a biopsychosocial condition that primarily affects women. It has a high rate of chronicity (49% after six months) and a worldwide prevalence of 34,1%, reaching 47% in South America.
Recent systematic reviews indicate that patients with TMD have higher salivary cortisol levels than healthy controls, that cortisol levels are higher in specific subtypes, and that cortisol levels decrease after intervention. However, the literature is still conflicting. Identifying psychosocial phenotypes while controlling for confounding factors, such as the use of medications that interfere with cortisol, may help clarify the role of hypothalamic-pituitary-adrenal axis dysregulation in chronic TMD.

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STEPS-TMD: Stress-Testing the Endogenous Pain System in Temporomandibular Disorders

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Fernando G. Exposto
Presenting Author: Fernando G. Exposto
Submitting Author: Fernando Exposto

Description:

Chronic pain affects one in five adults and remains difficult to assess mechanistically in clinical practice. Conditioned Pain Modulation (CPM) is the most common method for evaluating endogenous pain inhibition, yet it typically relies on a single trial that may not capture dynamic changes in inhibitory function. This study aims to introduce and evaluate a repeated “stress-test” CPM approach in patients with temporomandibular disorders (TMD). By assessing inhibitory responses across multiple consecutive trials, we aim to characterize individual inhibitory resilience profiles and determine whether this approach provides more reliable and clinically meaningful information than conventional single-trial CPM.

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Screen Time, Academic Performance and Facial Pain in Students: Are Digital Behaviors a Risk Factor?

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Nikolaos Christidis
Presenting Author: Giancarlo De la Torre Canales
Submitting Author: Giancarlo De La Torre

Description:

Screen time has become deeply embedded in university students’ academic and social routines. However, its relationship with academic performance, psychosocial health, sleep quality, and temporomandibular disorder (TMD) symptoms remains unclear.
This study aimed to investigate whether screen exposure, considering both duration and purpose, is associated with academic performance, mental health, sleep, ADHD-related symptoms, and orofacial pain among students in health-profession educations.

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Burning Mouth Syndrome Treated With Sphenopalatine Ganglion Pulsed Radiofrequency: A Case Report

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: James Jack
Presenting Author: James Jack
Submitting Author: Pablo Rojas

Description:

Burning Mouth Syndrome (BMS) is a chronic neuropathic pain condition characterised by persistent oral burning sensation without visible oral or mucosal pathology. Management remains challenging: it frequently responds poorly to pharmacological options, and interventional options are poorly defined. The sphenopalatine ganglion/pterygopalatine ganglion (SPG) is key in craniofacial nociception and autonomic regulation.
This case describes the successful use of a diagnostic SPG block followed by pulsed radiofrequency in a patient with refractory BMS, demonstrating a potential interventional strategy for this condition.

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Lip Strength in Painful Temporomandibular Disorders: A Cross-Sectional Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Jose Stechman-Neto
Presenting Author: Jose Stechman-Neto
Submitting Author: José Stechman-Neto

Description:

Temporomandibular disorders (TMD) may affect the stomatognathic system and alter tongue performance. In the ICD-11, TMD is classified as chronic primary orofacial pain and may be associated with functional impairment of trigeminally innervated muscles, including the tongue. This study aimed to evaluate tongue strength parameters and their relationship to swallowing function in individuals diagnosed with TMD.

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Efficacy of Lavender Essential Oil for Pain and Anxiety in Temporomandibular Disorder Patients

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Juliana Geremias Chichorro
Presenting Author: Juliana Geremias Chichorro
Submitting Author: Juliana Chichorro

Description:

Temporomandibular disorders (TMDs) are the second most prevalent chronic musculoskeletal condition after low back pain, affecting up to 34% of the global population 1-3.. They are characterized by pain or dysfunction in the temporomandibular joints, masticatory muscles, or associated tissues. Etiology is multifactorial, encompassing biological, psychological, and social determinants such as age, sex, parafunctional habits, sleep disturbances, stress, depression, and anxiety1. Women aged 20–40 show higher prevalence3. Despite advances in pathophysiology, effective therapies remain limited, with poor long-term adherence. This study evaluates inhaled Lavandula angustifolia essential oil as a potential intervention for pain and anxiety in muscular TMD.

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Painful TMD in OSA: Roles of Insomnia, Distress, and Sleep Bruxism

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Jarin Paphangkorakit
Presenting Author: Kanokrat Sitthikaew
Submitting Author: Kanokrat Sitthikaew

Description:

Temporomandibular disorders (TMD), insomnia, psychological distress, and sleep bruxism
frequently coexist in obstructive sleep apnea (OSA), yet phenotype-specific relationships remain unclear. Objective assessment of sleep bruxism using polysomnography in OSA populations is limited. This study determined the prevalence of painful TMD among OSA patients with TMD, and examined its associations with insomnia, anxiety, depression, and polysomnography-derived bruxism. We hypothesized that painful TMD would be associated with greater psychological distress, higher insomnia prevalence, and increased sleep bruxism activity.

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Temporomandibular Joint Ankylosis: A Prospective Study with Focus on Evaluating Treatment Outcomes

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Annika Rosen
Presenting Author: Lina Saleh
Submitting Author: Lina Saleh

Description:

Temporomandibular joint disorders (TMDs) are a common type of orofacial pain, affecting approximately 15-20% of the population. Patients who experience unsuccessful treatments through non-surgical methods, may have surgical intervention performed. TMDs such as temporomandibular joint (TMJ) ankylosis and heterotopic ossification can be managed with arthroplasty supplemented by an abdominal fat-transplant. Such surgeries have an overall success rate of approximately 80%. Factors predisposing to surgical failure have yet to be adequately investigated. Therefore, the aim of this study is to evaluate the impact on treatment outcomes, measuring pain intensity, function and quality of life in this multicenter project in Norway.

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Repeated Conditioned Pain Modulation Across Regions in Women With Myofascial Pain and Comorbidities

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Paulo César Rodrigues Conti
Presenting Author: Maria Emilia Servin Berden
Submitting Author: Maria Emilia Servin Berden

Description:

Conditioned pain modulation (CPM) is widely used to assess descending inhibitory function, yet its clinical interpretation remains limited by high interindividual variability and inconsistent group differences in chronic pain. Evidence suggests that single-trial protocols and restricted assessment sites may underestimate subtle changes in inhibitory capacity. Repeated CPM testing across anatomical regions may improve sensitivity, particularly in heterogeneous conditions such as painful temporomandibular disorders (TMD) associated with comorbidities. This study aimed to compare CPM responses across repeated trials in asymptomatic women and in those with myalgia/myofascial pain, with trigeminal and extratrigeminal comorbidities, exploring differences between anatomical regions and clinical groups.

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Isometric Masticatory Endurance and Electromyographic Data in Myogenous Temporomandibular Disorders

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Paulo César Rodrigues Conti
Presenting Author: Matheus Herreira-Ferreira
Submitting Author: Matheus Herreira-Ferreira

Description:

Understanding muscle function in individuals with chronic musculoskeletal pain has been a research focus for decades; however, important aspects remain unclear. Temporomandibular disorders (TMD) comprise a group of conditions affecting the temporomandibular joint, masticatory muscles, and associated structures. Symptoms such as fatigue, discomfort, stiffness, and pain are frequently reported, particularly in myogenous TMD, the most prevalent subtype. Given its high clinical frequency, it is important to clarify whether TMD alters muscle performance compared to healthy individuals. This study aimed to evaluate electromyographic (EMG) parameters during a masticatory isometric endurance task (MIET) in women with TMD compared to healthy controls.

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Neural Signatures of Virtual Reality Analgesia in Temporomandibular Disorder: A Randomized Trial

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Luana Colloca, MD, PhD, MS
Presenting Author: Nandini Raghuraman, MS, PhD
Submitting Author: Nandini Raghuraman

Description:

Temporomandibular disorder (TMD) is a chronic pain condition with 5–12% prevalence and a marked female predominance (1,2). Scalable, nonpharmacologic adjuvants can reduce reliance on medications, and mind–body interventions show moderate benefit in chronic pain (3,4). Virtual reality (VR) is a promising, low-cost approach, but mechanistic, rigorous studies are needed to accelerate translation. Resting-state EEG peak alpha frequency (PAF) reflects cortical excitability and information processing and is linked to pain reports and sensitivity (5,6). We aim to test whether at-home telehealth-delivered VR differentially affects daily pain and PAF synchronization compared with sham VR and no intervention in TMD.

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Percutaneous Glycerol Rhizotomy for Trigeminal Neuralgia: A Prospective Observational Cohort Study.

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Amina Kajee
Presenting Author: Amina Kajee
Submitting Author: Amina Kajee

Speakers:

  • Amina Kajee - MBBCH (WITS) DA (SA) FCA (SA) Department of Anaesthesia and Critical Care

Description:

In low‑ and middle‑income countries, there is limited access to theatre and critical cere services which constrains the use of surgical microvascular decompression for medically refractory trigeminal neuralgia (TN). Percutaneous glycerol rhizotomy (PGR) is a minimally invasive day‑case alternative. In this multicentre prospective observational cohort study, we undertook to prospectively assess pain, functionality and medication use before and after PGR in adults with medically refractory TN.

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Pain-Related Sexual Dysfunction in Women with Chronic Painful TMD: A Case–Control Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Victor Hugo Alves Ribeiro-Silva
Presenting Author: Victor Hugo Alves Ribeiro-Silva
Submitting Author: Victor Hugo Alves Ribeiro Silva

Description:

Chronic painful temporomandibular disorder (TMD) is a prevalent musculoskeletal condition associated with persistent pain, functional impairment, and psychosocial burden. Emerging evidence suggests that chronic pain may negatively influence sexual health; however, this relationship remains insufficiently explored in women with TMD. This study aimed to investigate whether women with chronic painful TMD present worse sexual function and greater psychosocial distress compared with pain-free controls, and to examine the perceived impact of TMD-related pain on sexual functioning.

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Anxiety and Depression Moderate Temporomandibular Disorder Pain and Oral Health Quality of Life

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Jun Wang
Presenting Author: Xin Xiong
Submitting Author: Xin Xiong

Description:

Systematic reviews and meta-analyses have confirmed the impact of TMDs on OHRQoL. Moreover, recent cross-sectional studies have shown that pain-related TMDs are negatively correlated with OHIP-TMDs scores and positively correlated with anxiety and depression. This suggests that anxiety and depression may influence the impact of TMDs on OHRQoL in patients, especially since the psychosocial domains of OHRQoL are frequently affected. This study aims to explore the mechanisms underlying the association between pain intensity and oral health-related quality of life (OHRQoL) in patients with temporomandibular disorders (TMDs), particularly the roles of anxiety and depression.

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Accelerated brain aging mediates the impact of insomnia on chronic pain interference

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Luana Colloca
Presenting Author: Yang Wang
Submitting Author: Yang Wang

Description:

Chronic pain is highly prevalent1 yet remains undertreated.2 A major challenge in pain management is its frequent comorbidity with other conditions that complicate treatment. Insomnia, a common sleep disturbance characterized by difficulties initiating or maintaining sleep, has been shown to exacerbate chronic pain severity.3-5 However, the neural mechanisms underlying the insomnia and chronic pain relationship remain poorly understood. Advanced brain-age derived from neuroimaging data6 has been linked to chronic pain outcomes,6 but how insomnia is involved has not been explored. This study examined brain-age to elucidate the neural underpinnings linking insomnia severity to chronic pain outcomes.

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RESULTS OF USING CONE BEAM COMPUTED TOMOGRAPHY IN PATIENTS WITH PERSISTENT IDIOPATHIC FACIAL PAIN

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Zykova Oksana Mikhailovna
Presenting Author: Zykova Oksana Mikhailovna
Submitting Author: Oxana Zykova

Description:

The belief that persistent idiopathic facial pain (PIFP) is psychogenic persists, yet evidence suggests it belongs to a heterogeneous group of conditions. Factors contributing to PIFP may include disproportionate responses to mild injuries, similar to complex regional pain syndrome, and unjustified dental interventions, which are considered likely etiological factors. Additionally, the diagnostic criteria for PIFP require the absence of detectable pathology via radiation diagnostics, leading to misunderstandings due to unclear guidelines on necessary methods and projections [1,2,3,4,5,6,7].
The aim was to identify radiological characteristics specific to patients with PIFP, as well as to formulate risk factors for its development.

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Magnetic Resonance Imaging Findings in Temoromandibular Joint and Juvenile Idiopathic Arthritis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Per Alstergren
Presenting Author: Alexandra Dimitrijevic Carlsson
Submitting Author: Alexandra Dimitrijevic Carlsson

Description:

Juvenile idiopathic arthritis (JIA) frequently involves the temporomandibular joint (TMJ), causing pain, cartilage and bone destruction, and disturbed mandibular growth. Early disease may lack pain despite active TMJ inflammation, making diagnosis difficult. Despite biologic therapies, progression of orofacial symptoms and MRI-detected TMJ inflammation remains poorly understood. Distinguishing true inflammation from normal skeletal immaturity on TMJ MRI is challenging, minor joint fluid or contrast enhancement without chronic changes should not confirm arthritis, whereas chronic changes are characteristic. Long-term studies show persistent consequences of TMJ Involvement.

The aim of this study was to evaluate longitudinal intra-articular changes in the TMJ in JIA.

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Translation, cross-cultural adaptation and validation of the FrePAQ-PL

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Małgorzata Starzec-Proserpio
Presenting Author: Aleksandra Budzisz
Submitting Author: Aleksandra Budzisz

Description:

Body perception disturbance is observed in people with chronic pain and is a potential target for treatment [1-3]. The Fremantle Pelvic Awareness Questionnaire (FrePAQ) adapted from the Fremantle Back Awareness Questionnaire, is a tool designed to identify disrupted body perception specific to chronic pain [4]. However, its psychometric properties have not yet been tested. This study aimed to develop and assess the psychometric properties of a Polish version of the questionnaire (FrePAQ-PL).

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Endometriosis-related pain: characteristics and sensory and cognitive-emotional interactions

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Josimari Melo DeSantana, PT, PhD
Presenting Author: Camilla Feitosa Mendes, PT, MSc
Submitting Author: Camilla Mendes

Description:

Endometriosis affects about 10% of women of reproductive age and is commonly associated with chronic pelvic pain. Beyond its nociceptive origin, increasing evidence suggests the involvement of nociplastic mechanisms, such as central sensitization (CS) and widespread pain. Considering that cognitive-emotional factors may also influence pain perception and contribute to CS, a multidimensional understanding of pain characteristics can impact how these women are assessed and treated. Therefore, this study aimed to characterize pain and cognitive-emotional factors, and to investigate predictors of pain intensity and CS, as well as the association between CS and pain distribution in women with endometriosis.

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The EndoCann trial: a preliminary analysis of participants� most impactful endometriosis symptoms

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: A/Prof Mike Armour
Presenting Author: Dr Amelia Mardon
Submitting Author: Amelia Mardon

Description:

Endometriosis is one of the most common causes of chronic pelvic pain (CPP) and is often associated with a myriad of other symptoms, including fatigue, nausea, and bloating. Many people with endometriosis-associated pelvic pain report inadequate response to current surgical and medical therapies. Cross-sectional data demonstrate that cannabis (both illicit and medicinal sources) may help people with endometriosis manage their pain and other symptoms. Our trial is evaluating the efficacy and safety of medicinal cannabis for endometriosis-related symptoms. The present analysis aims to describe the baseline demographic and clinical characteristics of participants enrolled to date, including participants’ most impactful symptoms.

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Exploring Predictors of Response to an Online Pain Management Program for Endometriosis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Prof Blake F Dear
Presenting Author: Dr Shianika Chandra
Submitting Author: Shianika Chandra

Description:

Chronic pelvic pain is the most concerning symptom of endometriosis and is associated with high rates of pain disability, depression, and anxiety [1]. Emerging research indicates the potential of psychological interventions in improving pain disability and psychological distress in endometriosis [2, 3]. Our randomized controlled trial (N = 193) of an online psychological pain management program for endometriosis demonstrated a ≥50% symptom improvement in pain disability, depression, and anxiety in the treatment group relative to control [4]. An important area for further research is to understand the characteristics of patients likely to benefit from such programs to guide their optimal use.

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Illness Invalidation in Endometriosis Is Linked to Poorer Quality of Life and Mental Defeat

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Emma Evans
Presenting Author: Emma Evans
Submitting Author: Bethany Carr

Description:

Endometriosis is a common gynaecological condition, yet experiences of symptom minimisation and dismissal by healthcare professionals, family and workplaces are widely reported. Illness invalidation may undermine psychological wellbeing and worsen health-related quality of life (HRQoL); however, its impact and mechanisms remain under-researched. We examined associations between invalidation and two clinically relevant outcomes: endometriosis-specific HRQoL and mental defeat (MD; feeling defeated in response to symptoms). We compared HRQoL and MD in high vs low invalidation groups across medical, family and work contexts; tested whether invalidation predicted outcomes beyond symptom/psychological covariates; and tested MD as a mediator between invalidation and HRQoL.

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Family Profiles Differentiate Risk for Intergenerational Transmission of Irritable Bowel Syndrome

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Tonya Palermo
Presenting Author: Francesca R. Querdasi
Submitting Author: Francesca Querdasi

Description:

Children are at increased risk of developing irritable bowel syndrome (IBS) if a parent has IBS, suggesting mechanisms of intergenerational transmission within the family. However, patterns of family factors that predict risk in early childhood, prior to when symptoms typically emerge, have not been identified. In a sample of parents with IBS and their young children without chronic abdominal pain, this study aimed to identify subgroups representing different constellations of family factors. We also tested subgroup differences on two outcomes associated with children’s risk for developing IBS: child emotional functioning and parental protectiveness towards children’s pain.

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Time-Varying Sympathetic Index of Electrodermal Activity as an Objective Biomarker for Visceral Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Hugo F. Posada-Quintero
Presenting Author: Hugo F. Posada-Quintero
Submitting Author: Hugo Posada-Quintero

Description:

There are few objective biomarkers available for measuring pain. The assessment of pain, especially chronic abdominal pain relies heavily on subjective reporting [1]. Chronic pain disorders, including irritable bowel syndrome (IBS) are commonly associated with autonomic dysfunction, characterized by increased sympathetic activity and reduced parasympathetic activity [2][3]. Autonomic activities can be quantified using non-invasive, wearable bioelectrical signals, such as electrodermal activity (EDA), serving as an objective pain biomarker, facilitating the development of more effective treatments [4][5]. This preliminary study investigated the feasibility of using an EDA-derived index to observe sympathetic activity in response to experimentally induced visceral and somatic pain.

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The Pain Everyone Missed: A Suspicious, Elusive Neuralgia Revealed By A Pain Physician

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: MUHAMMAD AASAM MASOOM MAAN
Presenting Author: MUHAMMAD AASAM MASOOM MAAN
Submitting Author: Muhammad Aasam Masoom Maan

Description:

Chronic genital pain in young women presents a diagnostic challenge, often involving multiple specialties due to its complex and overlapping aetiologies. Neuralgic causes such as genitofemoral and inguinal neuralgia are rare and frequently overlooked, leading to delayed diagnosis and prolonged patient suffering.

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Early-life prediction of early-onset dysmenorrhoea using machine learning before menarche

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Katy Vincent
Presenting Author: Omero B Poli-Neto
Submitting Author: Omero Poli-Neto

Description:

Dysmenorrhoea in adolescence is common and represents a significant risk factor for the development of chronic pain disorders in women later in life. Identifying girls at risk before menarche could lead to more effective preventive strategies and better pain outcomes in later life. We explored the potential of machine learning models to predict the risk of early-onset dysmenorrhoea in girls before menarche, using prospective data collected during pregnancy and childhood. The potential of ensemble models to outperform individual models in predicting early-onset dysmenorrhoea in girls will also be examined.

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A randomised nested cohort study on women with persistent pelvic pain: a real world study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Prof Sonia Grover
Presenting Author: Prof Sonia Grover
Submitting Author: Sonia Grover

Description:

Persistent pelvic pain(PPP), defined as pain in the lower abdomen or pelvis, for at least 6months.[1] PPP can adversely impact quality of life, productivity, mental health, sexual function.[2] It is commonly attributed to endometriosis, but only 50% of women with PPP have endometriosis.[3,4] PPP, like other persistent pain conditions, has biopsychosocial contributors.[5]

Laparoscopy is often undertaken to identify and remove endometriosis. However, long-term effectiveness of this surgery is limited[1]. In contrast, medical treatments are effective for long term management of both PPP and endometriosis.[6] We undertook a real world study to compare these approaches

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Targeting The Ventral Lateral Septum With Electroacupuncture and rTMS Relieves Visceral Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Guang-Yin Xu
Presenting Author: Shufen Hu
Submitting Author: Ruixia Weng

Description:

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by chronic visceral pain and limited therapeutic options. Converging evidence suggests that central neuromodulation may offer effective analgesia, yet the underlying circuit mechanisms and translational relevance remain incompletely understood. This study aimed to integrate preclinical and clinical evidence to evaluate the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS) and electroacupuncture (EA), with a specific focus on the ventral lateral septal nucleus (LSV) as a key neural substrate mediating visceral pain.

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Stratification of Endometriosis-Associated Pain after Surgery: A Prospective Multicenter Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Esther M. Pogatzki-Zahn
Presenting Author: Sören Marsmann
Submitting Author: Sören Marsmann

Description:

Endometriosis-associated pain shows marked inter-individual variability with large variations in symptoms, progression over time, and response to treatments including surgery. Mechanistic stratification is still weak because clinical pain trajectories are rarely linked to prospective and longitudinal psycho-social and molecular data. The prospective StEPP-UPP Non-Interventional Trial (NIT) aims to (1) define distinct perioperative pain trajectories and pain phenotypes, (2) build predictive models for certain pain phenotypes based on demographic and biopsychosocial data and (3) identify molecular signatures using an unbiased multi-omics approach to enable innovative diagnostic strategies, novel therapeutic targets in support of mechanism-informed, personalized management for patients after endometriosis surgery.

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Transversus Abdominis Plane Blocks in Chronic Abdominal Pain: Factors Influencing Treatment Response

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Benedict J. Alter, MD, PhD
Presenting Author: William Schultze, DO
Submitting Author: Will Schultze

Description:

Chronic abdominal pain (CAP) is a common complaint seen by pain physicians, with increasing prevalence.(1,2) Transversus abdominis plane (TAP) blocks have been increasingly used in the outpatient setting to treat CAP of varying etiologies.(3-5) A recent study identified multiple predictors of treatment response, including body mass index (BMI), neuropathic symptoms, pain duration, and the presence of depression or fibromyalgia.(6) However, this study included a small sample size. Our study aimed to investigate predictors of TAP block response in CAP on a larger scale, while also incorporating procedural data to further elucidate factors that may influence treatment success.

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Home-Based Brain Stimulation for Endometriosis-Related Chronic Pelvic Pain: Trial in Progress

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Nirav R. Shah, MD, MPH
Presenting Author: Ieva Karvelyte
Submitting Author: Ieva Karvelyte

Description:

Endometriosis affects around 10% of reproductive-aged women and commonly causes chronic pelvic pain, alongside dysmenorrhea, dyspareunia, and reduced quality of life. Standard hormonal, analgesic, and surgical approaches can be inadequate or limited by side effects, and many patients continue to experience substantial symptoms. Evidence suggests that altered central pain processing and central sensitization can contribute to persistent pain, creating an unmet need for non-pharmacological treatments that are accessible and scalable. We designed a fully home-based, double-blind, sham-controlled randomized trial to evaluate whether transcranial direct current stimulation (tDCS) can reduce pelvic pain and improve patient-reported functioning in endometriosis population.

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Role of Pulsed Radio frequency of Occipital Nerves in managing Chronic Headache - Case Series

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr. Vishal Gunjal
Presenting Author: Dr.Vishal Gunjal
Submitting Author: Vishal Gunjal

Description:

Occipital headache is a common but neglected entity in diagnosis & management of chronic headaches. Most patients have severe pain in occipital area sometimes associated with neck pain & unilateral headache with sharp radiation towards frontal area & associated with tingling & heaviness.
Most patients do well with medical management & good rehabilitation. But some tend to get severe pain over the years. Pulsed Radiofrequency of Greater & Lesser occipital Nerves serves as good Innovative therapy giving long term pain relief for such kind of patients without dependence on medication & with lesser side effects.

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Post-traumatic headache masking BPPV after mild traumatic brain injury: a case of vestibular agnosia

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Jason Taddeo
Presenting Author: Jason Taddeo
Submitting Author: Jason Taddeo

Description:

After mild traumatic brain injury (mTBI), symptom clusters consistent with post‑traumatic headache, visual strain, cervical, and fatigue often dominate clinical triage, potentially delaying identification of co‑occurring vestibular disorders. This case describes a worker with prominent headache provoked by screen/reading tasks and positional dizziness without classic vertigo. We aimed to show how reduced perception of self‑motion (“vestibular agnosia”) can mask objective benign paroxysmal positional vertigo (BPPV) and how guideline‑based vestibular screening can reduce overall symptom burden and disability in a medically complex, yet stable individual.

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Designing acceptability and feasibility testing for RCTs: Lessons from the NHMRC AUSMODIC study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Abdulaziz Albhlal
Presenting Author: Abdulaziz Albhlal
Submitting Author: Abdulaziz Albhlal

Description:

Feasibility and acceptability studies are essential for optimising the design and implementation of randomised controlled trials (RCTs), particularly for novel or complex interventions. However, there is limited practical guidance on how to systematically design and integrate these processes prior to a definitive trial. This NHMRC-funded study aims to illustrate a structured, theory-informed approach to designing and conducting acceptability and feasibility testing, using the AUSMODIC trial as an example. The AUSMODIC trial investigates antibiotic therapy for chronic low back pain associated with Modic type 1 changes, a condition with ongoing scientific debate and clinical uncertainty. The aim of this study is to describe the design and methodological approach used to develop and optimise trial processes prior to a definitive RCT.

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Somatosensory Rehabilitation Combined with tDCS in Neuropathic Pain: A Randomized Controlled Trial

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Sibele de Andrade Melo Knaut
Presenting Author: Sibele de Andrade Melo Knaut
Submitting Author: Sibele de Andrade Melo Knaut

Description:

Neuropathic pain (NP) is characterized by maladaptive peripheral and central plasticity, frequently manifesting as static mechanical allodynia and paradoxical painful hypoesthesia. Somatosensory Rehabilitation (SR) promotes peripheral afferent reorganization, whereas primary motor cortex (M1) transcranial direct current stimulation (tDCS) modulates cortical excitability and descending inhibitory pathways. The potential synergistic interaction between these mechanisms remains insufficiently explored. Thus, the objective of this study was to investigate whether SR combined with M1 tDCS enhances somatosensory recovery and pain reduction in individuals with NP.

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Lower Phase Angle Is Associated With Worse Pain-Related Quality of Life in Korean women

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Sunmin Kim
Presenting Author: Seon-Mi Lee
Submitting Author: Seon-Mi Lee

Description:

This study aimed to evaluate the association between phase angle and pain that affects quality of life, as assessed by the health-related quality of life instrument with 8 items (HINT-8).

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Motivation for physical activity and chronic pain: The power of social connection

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Caroline Guay
Presenting Author: Sylvie Lafrenaye
Submitting Author: Caroline Guay

Description:

Knowing that physical activity is beneficial is not enough: adherence remains complex, especially with chronic pain. This is a global challenge; the WHO reports that one in three adults is insufficiently active. The Versant AKOR 2024 project mobilized patients to collectively match the AKOR Adventurers' cross-Canada trek. This study explores how social affiliation and a collective challenge transform motivation despite physical fluctuations. The objective is to understand the evolution of engagement and to assess, six months later, the impact on quality of life and the sustainable adoption of an active lifestyle.

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Development of a Novel Questionnaire on Pain Science Education- The KNOwMorePain Questionnaire

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: MARIA TERESA CARRILLO-DE-LA-PEÑA
Presenting Author: UNAI GARCIA-GARCIA
Submitting Author: UNAI GARCÍA-GARCIA

Description:

Although pain science education (PSE) is increasingly implemented in clinical and research settings to promote reconceptualization of pain and adaptive lifestyle change, alignment between its transformative learning aims and current assessment approaches remains undeveloped. A recent review of PSE instruments reported substantial heterogeneity and limited psychometric robustness, highlighting the lack of theoretically grounded approaches to assess conceptual change (Reezigt et al., 2026). Therefore, we aimed to develop an instrument to assess meaningful conceptual change aligned with the core aims of PSE.

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Driving Clinical Adoption:A Systems Framework To Translate Biopsychosocial Musculoskeletal Pain Care

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Helen Slater
Presenting Author: Wendy Ng
Submitting Author: Wendy Ng

Description:

Clinical practice guidelines consistently advocate a biopsychosocial approach to musculoskeletal pain care, yet provide limited guidance on how to translate it effectively within modern healthcare systems. This research proposes a data-driven systems framework to support the sustainable adoption of biopsychosocial care for musculoskeletal pain, integrating three complementary perspectives:
1. Whole-of-health system perspective: Identifying factors influencing healthcare professionals’ biopsychosocial adoption.
2. Behavioural perspective: Identifying behavioural determinants that can potentially change practice and support implementation of high-value musculoskeletal pain care.
3. Educational perspective: Identifying the educational practices and evidence indicators of biopsychosocial clinical adoption perceived by educators to facilitate clinical translation.

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How Sociocultural Histories Shape Refugee Pain Experiences: Perspectives of Healthcare Professionals

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: G. Lorimer Moseley
Presenting Author: Karma Phuentsho
Submitting Author: Karma Phuentsho

Description:

Chronic pain is highly prevalent (83%) among refugees [1] and frequently remains undertreated. Healthcare professionals often face challenges in providing pain care for refugees with lack of evidence or guideline to inform effective management strategies [2]. Some studies have engaged refugees with lived experiences [3] but there is scarcity of research involving healthcare professionals working directly with refugees. We aimed to understand a broader range of healthcare professionals’ insights and perspectives related to the factors that influence refugees’ access to and engagement with pain management.

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Age-Stratified Determinants of Headache Among Older Adults: A National Population-Based Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Jimmy Fransisco Abadinta Barus, MD, Ph.D, Neurologist
Presenting Author: Aurelia Vania, MD, Neurologist
Submitting Author: Aurelia Vania

Description:

Headache is a major contributor to chronic pain and disability across the lifespan, yet remains poorly characterized among older adults, a rapidly growing global demographic. Evidence on headache determinants in advanced age is limited, particularly in low- and middle-income countries, where multimorbidity, psychosocial vulnerability, and functional decline are prevalent. This study aimed to identify independent sociodemographic, clinical, and psychosocial determinants of headache across older age groups using nationally representative data from the Indonesian Family Life Survey wave 5 (IFLS-5).

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Work-Related Musculoskeletal Disorders and Pain in Brazil: National Trends from 2006 to 2024

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Felipe J. J. Reis
Presenting Author: Daiane Lazzeri de Medeiros
Submitting Author: Daiane Medeiros

Description:

Work-related musculoskeletal disorders are a major cause of pain, disability, and work absence worldwide, with substantial socioeconomic consequences. In low- and middle-income countries, national epidemiological data remain limited, hindering effective prevention and policy development. In Brazil, work-related musculoskeletal disorders have been mandatorily reported since 2006 through a national surveillance system. This study aimed to describe national trends and the epidemiological profile of work-related musculoskeletal disorders in Brazil between 2006 and 2024, with a specific focus on pain, functional impairment, and occupational risk factors.

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Awareness and Clinical Utilization of Nociplastic Pain among Pain Physicians: Cross-sectional Survey

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr. Gautam Das
Presenting Author: Dr. Suzen Sumeet Kaur
Submitting Author: Suzen Sumeet Kaur

Description:

Background: Nociplastic pain (NP)is an increasingly recognized mechanistic descriptor in chronic pain since its adoption by the International Association for the Study of Pain (IASP), yet its usage in routine clinical practice depends on clinician awareness and use of structured detection approaches. Data on awareness of NP has not been calculated since its introduction. Hence, we proposed to assess its awareness among Indian pain physicians.

Aim: To assess awareness, familiarity, and clinical utilization of NP concepts among Indian pain physicians and pain-medicine trainees.

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Prevalence of WMSD among Healthcare Workers in Brazil (2007-2023)

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Tatiane Araújo dos Santos
Presenting Author: Giulia Santos Santana
Submitting Author: Giulia Santana

Description:

Work in the health sector involves exposure to various risk factors, including ergonomic demands, repetitive movements, and inadequate postures, primary triggers for Work-Related Musculoskeletal Disorders (WMSD)(1,2). These conditions are the most frequent occupational diseases in Brazil(3), impacting professionals’ quality of life and health service efficiency(3–5). Despite their relevance, there is a gap in knowledge regarding updated longitudinal studies that map the national prevalence and the profile of affected healthcare workers (HCW) over the last decades. Thus, the objective of this study was to estimate the prevalence and sociodemographic profile of WMSD among HCW in Brazil between 2007 and 2023.

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Opioid Use in Jordan: A National Analysis of Prescriptions, 2021�2024

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: CHE SURAYA MOHD ZIN
Presenting Author: Hussam Mizher
Submitting Author: Hussam Abdeljabar Ahmad Mizher

Description:

Opioids are considered the most potent analgesics and their prescribing rates have increased drastically over the last decade. Despite their effectiveness, opioids are associated with substantial risks, including addiction, abuse, and overdose-related mortality. While many countries have reported national prescribing trends, data from the Middle East remain limited, and Jordan has no published population-based evaluation of opioid use. This study explored national trends in opioid prescriptions in Jordan from 2021 to 2024, examined the types of opioids used, and compared prescribing patterns between cancer and non-cancer patients, including short-term and long-term non-cancer use.

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The hidden pain: importance of the myofascial and mixed pain in a orthopedic setting public hospital

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Lin Tchia Yeng
Presenting Author: Mariana Alcantara Roldi de Azeredo
Submitting Author: Mariana Alcantara Roldi de Azeredo

Description:

Myofascial pain syndrome (MPS) is a common but often “hidden” contributor to chronic musculoskeletal and neuropathic pain, characterized by trigger points causing local and referred pain, functional limitation and weakness. Despite being reported in up to 85% of adults over the lifetime, it is frequently underrecognized in orthopedic settings, because its manifestations overlap with joint disorders, fibromyalgia, neuropathic pain and other conditions of chronic pain, partly due to the diagnostic criteria are essentially clinic. Chronic pain commonly presents as mixed phenotypes, with myofascial and neuropathic components influencing the adequate treatments. However, data in Latin American populations remain limited.

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Mapping the Spatiotemporal Trajectories of Pain Across the Lifespan.

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Etienne Vachon-Presseau
Presenting Author: Matt Fillingim
Submitting Author: Matt Fillingim

Description:

Pain is a leading cause of disability worldwide, yet global, age resolved reference estimates for common bodily pain sites are lacking. Existing prevalence estimates are fragmented, regionally biased, and often limited to single pain phenotypes. We aimed to construct global lifespan trajectories of self reported pain across multiple anatomical sites using harmonized individual participant data. Our objective was to characterize how pain prevalence and intensity vary by age, sex, anatomical site, and world region, and to provide population level benchmarks for clinical, epidemiological, and policy applications.

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Prevalence and risk factors for persistent post-operative opioid use after major surgery in England

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Li-Chia Chen
Presenting Author: Neetu Bansal
Submitting Author: Neetu Bansal

Description:

Persistent post-operative opioid use (PPOU) is increasingly recognised as an important adverse outcome following major surgery, contributing to long-term opioid dependence, reduced quality of life and increased healthcare utilisation (1,2). While evidence from North America suggests that 5–10% of opioid-naïve surgical patients develop persistent opioid use, UK-specific data remain limited and differences in prescribing systems and perioperative care pathways limit generalisability (3-7). Understanding the epidemiology of PPOU within the UK context is essential to inform prevention strategies and opioid stewardship initiatives. This study aimed to estimate the prevalence of PPOU following major surgery in England and identify associated risk factors.

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Global Research Trends of High-Impact Chronic Pain: A Bibliometric Analysis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Liang Yao, Long Ge
Presenting Author: Qiuyu Yang, Liang Yao
Submitting Author: Qiuyu Yang

Description:

Population having high-impact chronic pain (HICP) accompanied by major life or work-related activity limitation. Recently, studies on HICP have received increasing attention. However, changes in scientific knowledge and the latest research trends of HICP have not been explored adequately.

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Prescribing Patterns Across Social Determinants in Low Back Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Ryan Pontiff
Presenting Author: Ryan Pontiff
Submitting Author: Ryan Pontiff

Description:

Nonspecific low back pain (NLBP) is among the leading causes of disability worldwide, yet treatment selection remains highly variable across patient populations. Social determinants of health (SDoH), including economic instability, housing insecurity, educational attainment, and psychosocial adversity, may contribute to disparities in clinical decision-making; however, their specific influence on NLBP treatment pathways remains poorly characterized. This retrospective cohort study examined the association between documented SDoH factors (ICD-10-CM Z55-Z65) and the selection of pharmacologic and rehabilitative treatments within 6 months of NLBP diagnosis, using real-world electronic health records (EHR).

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Prevalence and Impact of Chronic Pain among Minority Ethnic Groups in the United Kingdom

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Jenny Lewis
Presenting Author: Seba Ghosh
Submitting Author: Seba Ghosh

Description:

Approximately 43% of UK adults experience chronic pain (1). Existing literature demonstrates a substantial variability in the reported prevalence of chronic pain among Minority Ethnic populations in the UK, with estimates ranging from 34% to 72% (2,3). These findings indicate limited precision in prevalence estimates and overlook the possibilities of differences between these populations.

Aim: This study aimed to estimate the prevalence and impact of chronic pain among Minority Ethnic groups compared to White ethnic groups in the UK using data from the English Longitudinal Study of Ageing (ELSA).

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ICEPAIN: National Longitudinal Cohort Advancing Multidimensional Understanding of Pain Trajectories

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Thorbjorg Jonsdottir
Presenting Author: Thorbjorg Jonsdottir
Submitting Author: Thorbjörg Jonsdottir

Description:

Chronic pain is a complex, personal, condition shaped by biological, psychological, social, and behavioural influences. Although it may originate from injury or pathology, its persistence and impact are strongly influenced by health behaviours, socioeconomic conditions, trauma exposure, and psychosocial vulnerability. Moving beyond biomedical models toward a multidimensional framework is essential. Large-scale longitudinal population studies integrating biomedical, psychosocial, and lifestyle domains are needed to inform prevention strategies and health policy.
This study aims to develop and expand a nationally representative longitudinal cohort (ICEPAIN) mapping pain prevalence, trajectories, and associated psychosocial and lifestyle determinants, with global applicability.

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Global Burden and Cross-country Inequalities in Low Back Pain (1990 to 2021) and Projections to 2050

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Gaojian Tao
Presenting Author: Yin Li
Submitting Author: Yin Li

Description:

Low back pain (LBP) significantly impacted quality of life and has become the leading cause of disability-adjusted life years (DALY) worldwide. This study aimed to evaluate the global burden and temporal trends of LBP from 1990 to 2021, while identifying the latest attributable risk factors.

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Is the menopausal symptom-pain link unique to women? A cross-sectional study of 6,000 adults

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Shinsuke Inoue
Presenting Author: Yukiko Shiro
Submitting Author: Yukiko Shiro

Description:

The prevalence of pain increases during middle age, a period marked by drastic fluctuations in sex hormones. While the relationship between menopausal symptoms and pain is well-documented in women, it remains unclear whether similar associations exist in men, who also experience age-associated hormonal changes. This study aimed to investigate the relationship between menopausal symptoms and pain across both sexes, examining whether the clinical significance of these symptoms—often considered exclusive to women—extends to men in the context of pain management and health-related quality of life (HRQOL).

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Decision-making autonomy in chronic pain: ethical implications and a pilot MacCAT-T study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Julien Nizard
Presenting Author: Julien NIZARD
Submitting Author: Marguerite d'Ussel

Description:

Patient decision making autonomy (DMA) is a cornerstone of medical ethics [1], yet is rarely evaluated in chronic pain care. Chronic pain, now recognized as a disease [2], requires complex multidisciplinary management, which presupposes adequate decisional capacity. However, persistent pain may alter cognitive, emotional and judgment processes, potentially limiting DMA. This pilot study examined whether first‑time patients attending a tertiary pain center possess sufficient DMA to consent to proposed treatments, comparing clinicians’ subjective assessments with a standardized tool while identifying potential autonomy deficits with implications for clinical practice, personalized care, and ethical decision‑making [3].

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Leaves, needles and pills: syncretism and multicultural influence on pain management in Peru

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Alessandra Torres Yabar
Presenting Author: Alessandra Torres Yabar
Submitting Author: Alessandra Torres

Description:

Peru’s medical landscape represents a syncretism of three eras: pre-Columbian, the introduction of Western medicine in the 16th century and Asian techniques like acupuncture via 19th century immigration (Barrie Fairley, 2007; Foster, 1988; Kelly, 1990; Rivera-Vargas, 2019; Palma, 2023). Despite Western medicine prevailing in hospital settings this historical convergence of cultures has created an environment of medical pluralism, which integrates herbal remedies and rituals, that persists to this day (Bohensky, 2011; Bussmann, 2013; Herrera, 2022).

We aim to map how pain management has evolved in this context and evaluate the impact on care and patient adherence.

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The prevalence of spinal pathologies in children and adolescents seeking care for back pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Gisela Cristiane Miyamoto
Presenting Author: Yasmin Brasileiro de Souza
Submitting Author: Yasmin Souza

Description:

Back pain is a leading cause of disability among children and adolescents worldwide. While it is often assumed that only a small proportion of those seeking care for back pain have serious underlying conditions, this assumption is primarily based on adult data, leaving a critical knowledge gap regarding the reality in younger populations. No studies have reviewed the evidence on prevalence of spinal and non-spinal pathologies in children and adolescents. The aim of this systematic review was to estimate the prevalence of spinal and non-spinal pathologies in children and adolescents seeking care for back pain.

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When Pain Care Fails: Analgesia, Delirium, and Criminal Responsibility in Japan (2019�2025)

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Keiko Yamada
Presenting Author: Naoki Mizunuma
Submitting Author: NAOKI MIZUNUMA

Description:

Severe postoperative pain and emergence delirium may present with agitation and other behaviors that are misinterpreted when clinical context is missing. We report a breast-conserving surgery case in which insufficient intraoperative analgesia was followed by intense pain, agitation, and an allegation of sexual assault against the surgeon, precipitating prolonged criminal proceedings. We aimed to identify pharmacologic and system contributors to uncontrolled pain and emergence delirium, examine gender and institutional bias in pain assessment and symptom interpretation, and propose interdisciplinary strategies to prevent clinical symptoms from being misclassified outside healthcare settings.

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EXERGAMES IN THE MANAGEMENT OF MUSCULOSKELETAL DISORDERS IN OLDER ADULTS: A SYSTEMATIC REVIEW

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Jorge Fuentes C
Presenting Author: Jorge Fuentes C
Submitting Author: Jorge Fuentes

Description:

The evidence on the clinical effects of exergames in older adults has been studied and focused on neurological areas, mood disorders, mental health, cognitive aspects, and fall prevention. However, the effects of Exergames on the musculoskeletal area in this population is very unclear. In this research, we seek to explore the role of exergames on various physical, functional, and psychosocial variables.

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Use of Body protection compound-157 (BPC-157) in Soft Tissue Injuries: A Systematic Review

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Hany Demian
Presenting Author: Rifat Rehmani
Submitting Author: Rifat Rehmani

Description:

Therapeutic peptides are promising adjuncts in the management of soft tissue injuries. BPC-157 is a naturally occurring gastric peptide that promotes mucosal integrity and homeostasis. Preclinical studies show its potential for promoting healing in musculoskeletal injuries such as tendon ruptures, ligament tears, and muscle injuries. With no US Food and Drug Administration approval and its use being banned in professional sports, it is increasingly used by clinicians and athletes.

Aim:
Two-fold: (1) To provide a comprehensive literature review of the BPC-157 in term of soft tissue regeneration and (2) reveal the mechanism of action, musculoskeletal effects, metabolism, and safety profile.

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What is the lived experience of CRPS?: A thematic synthesis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Tim McVicar
Presenting Author: Tim McVicar
Submitting Author: Tim McVicar

Description:

Complex regional pain syndrome (CRPS) is a limiting and distressing pain condition. The majority of CRPS research has drawn on biomedical frameworks, testing quantitative measures that focus on diagnosis, mechanisms, and pharmacological treatment efficacy. Whilst this information is valuable, the experience expressed by those living with CRPS remains poorly understood. A 2015 review found only two studies addressing this gap (Johnston et al., 2015). Since then, research has expanded, creating an opportunity for a thematic synthesis to update the understanding of living with CRPS. The aim of this study is to synthesise available literature exploring the lived experience of CRPS.

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Analysis of research hotspots and emerging trends in mitochondria and pain from 2004 to 2024

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Yimeng Xia
Presenting Author: Yimeng Xia
Submitting Author: Yimeng Xia

Description:

Background: Mitochondria play a crucial role in various cellular processes, and their dysfunction has been increasingly recognized as a significant factor in the pathophysiology of chronic pain. Despite growing interest in this area, a comprehensive bibliometric analysis of the research trends, key themes, and influential contributions in the study of mitochondria and pain has not been conducted. This study aims to fill this gap by providing a detailed overview of the research landscape from 2004 to 2024.

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Comparison of Efficacy and Safety of Non-Oral Therapeutic Interventions for Zoster-Associated Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Sun Tao
Presenting Author: Hao Yuchen
Submitting Author: Yuchen Hao

Description:

Zoster-associated pain (ZAP) encompasses acute, subacute, and postherpetic neuralgia stages. It often results in persistent sensory abnormalities and substantial impairment of quality of life. Although oral pharmacotherapy remains the first-line and foundational approach, its effectiveness may be limited in some patients; accordingly, non-oral interventions are investigated as complementary or escalated strategies. However, high-quality evidence investigating the relative efficacy and safety of these interventions remains scarce.
This study intended to systematically evaluate the efficacy and safety of a variety of non-oral therapeutic interventions for ZAP, thereby providing evidence to inform clinical decision-making.

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Knowledge and Perceptions of Chronic Pain and Opioid Prescribing in Physicians in Armenia

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Narine Movsisyan
Presenting Author: Narine Movsisyan
Submitting Author: Narine Movsisyan

Description:

Chronic pain remains a major public health concern and is frequently undertreated. Evidence indicates that 30–40% of patients with early-stage cancer and 70–80% with advanced disease experience inadequate pain control. Despite established clinical guidelines, barriers to effective pain management persist, including insufficient training, regulatory restrictions on opioid prescribing, and misconceptions regarding opioid use and addiction.
This cross-sectional survey aimed to evaluate knowledge, attitudes, and self-reported practices related to chronic pain management and opioid prescribing among primary care physicians in Armenia, and to identify demographic and systemic factors associated with suboptimal pain care.

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Mapping Referral Pathways To A Tertiary Pain Clinic In Sri Lanka: Retrospective Observational Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Ashani Ratnayake
Presenting Author: Ashani Ratnayake
Submitting Author: Ashani Ratnayake

Description:

Chronic pain is a leading cause of disability affecting the quality of life. Sri Lanka has a limited number of pain clinics attached to tertiary care centers. Organized referral pathways play an important role in improving care and overcoming the disadvantage of limited access. Understanding referral pathways, timing and reason for referral is important to improve access, efficiency and equity of pain care in low and middle-income settings. The objective of this study is to describe referral pathways, timing, and reason for referral to a tertiary pain clinic and to identify delays and system-level barriers to timely specialized pain care.

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Development of a Monitoring and Evaluation Plan for a Chronic Pain Care Program

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Erica Brandão de Moraes
Presenting Author: Barbara Ventura Fontes
Submitting Author: Barbara Fontes

Description:

Chronic pain affects approximately 40% of Brazilian adults and represents a major public health challenge. Although multidisciplinary pain services are available in some public institutions, systematic monitoring and evaluation processes remain limited, affecting care quality and program sustainability. Structured evaluation strategies are necessary to improve clinical outcomes, safety, and continuity of care for individuals living with chronic pain. This project aims to develop and implement a Monitoring and Evaluation Plan for a chronic pain program within the Brazilian public health system.

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Case Report: Ulcer and Fistula Formation Following Neurolytic Ganglion Impar Block

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Mohammad Ghalib Riziq
Presenting Author: Mohammad Ghalib Riziq
Submitting Author: Mohammad Riziq

Description:

Introduction
Patients with advanced rectal cancer often experience severe pain inadequately managed by opioids
alone. Ganglion Impar Block (GIB) (Fig. 1) offers an alternative for perineal pain, targeting the
sympathetic innervation of the lower rectum and perineum. While generally safe, GIB carries risks like
infection, visceral perforation, and nerve injury. Neurolytic agents, such as alcohol, provide long
lasting pain relief but can cause complications like nerve necrosis and persistent neuritis (Fig. 2). This
report details a rare complication of ulcer and fistula formation following neurolytic GIB in a metastatic
rectal cancer patient.

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Interdisciplinary approaches for Group Health Promotion in Chronic Pain patients

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dartcleia Moura Martins Neves
Presenting Author: Dartcleia Moura Martins Neves
Submitting Author: Dartcleia Moura Martins Neves

Description:

Chronic pain is a multifactorial condition requiring interdisciplinary intervention aligned with the biopsychosocial model. However, public health systems in low- and middle-income countries, such as Brazil, often face a critical gap between surging clinical demand and restricted access to mental health services. This disparity underscores the urgent need for innovative, cost-effective solutions that integrate physical rehabilitation with psychosocial support. Hence, this study presents an interdisciplinary collective protocol for chronic pain intervention, designed as a scalable strategy to expand mental health care access and improve therapeutic outcomes within the public health sector.

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COMPREHENSIVE PAIN MANAGEMENT IN GHANA, A CALL FOR ACTION.

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr. Robert Djagbletey
Presenting Author: Dr. Zan-nairah Napaga Tahiru
Submitting Author: Zan-nairah Tahiru

Description:

Chronic pain is a public health concern confronting healthcare systems worldwide. About 25% of the global adult population suffers from chronic pain of varying aetiologies, making it a leading cause of years lived with disability and a profound driver of economic productivity loss. 1,2,3
Ghana, a country located in the heart of West Africa is no exception to this global phenomenon with an estimated population of 30.8 million, chronic joint pain, arthritis and “rheumatism” is the third most sited Out Patient Department diagnosis(6%) after Malaria(19.6%) and upper respiratory tract infection(10.4%). 4,5,6
Despite the burden of chronic pain conditions in Ghana, the country is yet to have a multidisciplinary pain management centre. There are several challenges that hinder the establishment of a comprehensive chronic pain management centre. These challenges span human resources, physical and technological infrastructure, financing and health insurance, clinical systems, policies and protocols, education, and sociocultural factors. 7,8,9

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The Alberta Virtual Pain Program: A Learning Health System for Scalable Virtual Pain Care

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Magali Robert
Presenting Author: Elena Lopatina
Submitting Author: Elena Lopatina

Description:

Chronic pain affects approximately 1,000,000 individuals in Alberta, Canada, many of whom experience fragmented, difficult-to-navigate care and report having to “fight” to access needed services (1). In response to calls for system-level change, the Alberta Virtual Pain Program (AVPP) was established as Canada’s first publicly funded, province-wide chronic pain program. Recognizing the distinct physiology of chronic pain, AVPP provides timely, centralized access to patient-centred, multidisciplinary, non-pharmacologic care. A core component is a six-week, virtual group-based pain science education and self-management program, featuring twice-weekly clinician- and peer support worker (PSW) -led sessions, with follow-up support for up to 12 months.

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Pain Management Practices in Bangladesh: A Situation Analysis for Improved Patient Outcomes

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Professor AKM Akhtaruzzaman
Presenting Author: Kazi Mahzabin Arin
Submitting Author: Kazi Mahzabin Arin

Description:

Chronic pain is a major global health concern, affecting over 30% of the population worldwide and imposing substantial personal, social, and economic burdens1. The challenge is particularly pronounced in low- and middle-income countries (LMICs), where access to pain services, specialist training, and essential analgesics remains limited2,3. Low back pain is a leading cause of disability globally and contributes significantly to clinical and economic burden in LMICs4In Bangladesh, there is a significant gap in available information concerning pain management practices, institutional capabilities, and the challenges encountered in delivering effective care. This study aimed to conduct a situational analysis of pain management practices among physicians in Bangladesh, identifying gaps in training, resources, clinical protocols, and multidisciplinary care.

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A Review of Referral Patterns and Consultation Outcomes of a Pain Clinic in North East England

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Sailesh Mishra
Presenting Author: Luke Davis
Submitting Author: Luke Davis

Description:

Pain management clinics receive referrals from a range of primary and secondary care services. Understanding referral sources and subsequent management decisions can inform service planning and pathway optimisation. This audit aimed to analyse the referral origins and subsequent consultation outcomes of new patients attending a pain management clinic in Newcastle upon Tyne, England, with particular focus on onward referral, intervention planning, and follow-up arrangements.

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Strengthening Cancer Pain Services by Government -NGO Partnership in regional cancer centre in India

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Mohammed Yunus Khilji
Presenting Author: Vivek Mehta
Submitting Author: Mohd Yunus Khilji

Description:

Provision of Cancer Pain and palliative care services is essential part of comprehensive cancer treatment. Acharya Tulsi Regional Cancer Treatment and Research Institute (ATRCTRI) Bikaner is one of the largest centre in northwestern India. There is immense need for dedicated services which should includes outpatient, daycare, inpatient and home-care.
The major problem in government institute was inconsistency of staff due to non-availability/frequent transfers. Due to this resource constraint, we were able to offer only OPD service limited to provide morphine and other pain medications. Hence We started a project with help of Cipla Foundation to strengthen the existing services

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Why is a Cerebral Palsy specific Core Outcome Set needed for chronic pain?

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: A/Prof Adrienne Harvey
Presenting Author: Nadine Smith
Submitting Author: Nadine Smith

Description:

Cerebral palsy is the most common childhood onset physical disability. Three quarters of children and young people with cerebral palsy experience chronic pain, however biopsychosocial assessment has not been part of routine care. Previously developed outcome sets are limited due to due to lack of observational measures, omission of tools that assess impact on emotional functioning, and lack of development with people with lived experience.
This study aimed to develop a Core Outcome Set (COS) of valid, reliable and feasible tools that assess chronic pain interference and impact on emotional functioning specifically for children and young people with cerebral palsy.

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Physiotherapists� Perspectives on Mindfulness Meditation for Pain Management: A Qualitative Study.

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Ramakrishnan Mani
Presenting Author: Ramakrishnan Mani
Submitting Author: Ramakrishnan Mani

Description:

Mindfulness meditation (MM) is a mind–body practice that supports health and well‑being by cultivating focused attention and non‑reactive awareness [1]. Although evidence shows that MM can benefit people with persistent pain [2], its integration within physiotherapy practice remains limited and underexplored [3,4,5]. This study examines New Zealand physiotherapists’ perspectives and experiences of MM as a clinical intervention in physiotherapy practice settings, with the aim of identifying key barriers, facilitators, and implications for patient care.

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Low-Temperature Offset Analgesia Supports C-Fibre Sufficiency

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Stuart WG Derbyshire
Presenting Author: Stuart WG Derbyshire
Submitting Author: Stuart William George Derbyshire

Description:

Offset analgesia (OA) is a rapid and disproportionately large reduction in pain following a small decrease in noxious stimulation [1]. The mechanisms underlying OA remain uncertain, and recent work has raised the possibility that specific peripheral fibre activation may be required [2]. C-fibres have heat activation thresholds below ~45°C, whereas A-delta mechano-heat (AMH) fibres typically respond at higher temperatures. If C-fibre activation is sufficient to generate OA, then OA should be observable at noxious temperatures below 45°C.

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Clinician views of behavioural intervention to reduce low-value care for back pain in emergency care

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Adrian Traeger
Presenting Author: Sweekriti Sharma
Submitting Author: Sweekriti Sharma

Description:

Low back pain is one of the leading causes of emergency department (ED) presentations globally.1 Although guidelines recommend against opioids and routine imaging, about 70% of people with low back pain receive opioids, and ~25% receive imaging in Australian EDs.3 We recently completed a trial of behavioural interventions to reduce low-value care for back pain in the ED called NUDG-ED. The trial found clinician nudges (electronic alerts) did not reduce low-value care for low back pain. We aimed to explore the extent to which our findings can be explained by clinicians’ awareness and perceptions of the electronic alerts.

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No Universal Mechanical Threshold for Pain: Evidence from Knee Acceleration and Impulse in Knee OA

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Takahiko Fukumoto
Presenting Author: Takahiko Fukumoto
Submitting Author: Takahiko Fukumoto

Description:

Quantitative assessment of pain using mechanical parameters remains a major challenge in clinical biomechanics. Our previous study ;IASP2024 using accelerometers demonstrated that reductions in knee acceleration were associated with decreased pain; however, no clear acceleration threshold for pain could be identified.
The present study aimed to further investigate whether a mechanical threshold for pain exists by examining frontal plane knee joint impulse in addition to acceleration-based measures.

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Severity and timing of trauma exposure and chronic pain alter white matter integrity in older adults

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Yann Quidé
Presenting Author: Tong En Lim
Submitting Author: Tong En Lim

Description:

Lifetime exposure to trauma increases the risk and persistence of chronic pain later in life. Evidence for alterations in white matter integrity has been associated with disrupted communication among sensory, affective, and pain-regulatory systems in separate studies of chronic pain and trauma. Despite the high comorbidity between trauma and chronic pain in older adults, the combined effects of trauma exposure and chronic pain on white matter integrity remain unclear. This study aimed to examine the effects of trauma exposure at different neurodevelopmental periods (childhood, adulthood, and both) on white matter microstructure integrity in older adults experiencing chronic pain.

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Sex Differences in Pain Memory and Contextual Processing: A Virtual Reality Pain Conditioning Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: FROT Maud
Presenting Author: VAN EYCKEN Juliette
Submitting Author: Juliette Van Eycken

Description:

Chronic pain affects women disproportionately, yet mechanisms underlying sex differences in pain memory remain unclear. This study investigates how pain conditioning influences pain memory, contextual perception, and implicit memory processing, with particular attention to sex-specific patterns.

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Manifestation of experimentally induced central sensitization in highly trained athletes.

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Cédric Lenoir
Presenting Author: Vladimir Aron
Submitting Author: Vladimir Aron

Description:

Athletes, compared with non-athletes, exhibit higher pain threshold and tolerance (Thornton et al., 2024). The susceptibility to develop central sensitization (CS) – defined as an "increased responsiveness of nociceptive neurons in the central nervous system" (IASP) has not been studied in this population. Here, we aimed to compare secondary hyperalgesia (SH), a manifestation of CS (Leone et al., 2024), elicited experimentally in volunteers grouped according to their level of regular physical activity (elite, intermediate and sedentary).

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Spatial summation of pain induced by remote nociceptive stimulation

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Wacław M. Adamczyk
Presenting Author: Wacław M. Adamczyk
Submitting Author: Waclaw Adamczyk

Description:

Spatial summation of pain (SSp) refers to the psychophysical increase in perceived pain intensity as the spatial extent of nociceptive stimulation increases. Previous studies have demonstrated SSp when stimulation is distributed within a single dermatome or across adjacent dermatomes. However, it remains unclear whether stimulation applied to clearly remote body regions also elicits SSp. Here, we examined unilateral and bilateral SSp using electrocutaneous stimulation to determine whether spatially separated nociceptive inputs, including those delivered to opposite limbs, produce enhanced overall pain perception.

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Using EMA to Characterise Biopsychosocial Influences on Chronic Pain in Parkinson's Disease

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr Kirsty Bannister, Dr Whitney Scott
Presenting Author: Zara Shafiq Rehman
Submitting Author: Zara Rehman

Description:

Parkinson's disease (PD) is the second most prevalent neurodegenerative condition worldwide, with cases anticipated to double within 30 years (Tolosa et al., 2021). Among its many non-motor symptoms, up to 85% of people with PD experience chronic pain (Viseux et al., 2023). As a multidimensional experience shaped by complex biopsychosocial influences, chronic pain remains poorly managed in this population (Marques & Brefel-Courbon, 2020; Tai & Lin, 2020). While psychosocial factors are extensively studied in the broader pain literature, equivalent research in PD is limited, and most existing work is cross-sectional.
This study investigated within-person associations between psychosocial factors and chronic pain outcomes in PD using Ecological Momentary Assessment (EMA). We hypothesised that higher pain-related worry and stigma would be associated with worse pain outcomes (greater intensity, interference, and poorer mood and sleep), whereas greater psychological flexibility and emotional support would be associated with better outcomes and lower worry and stigma.

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Conditioned Pain Modulation in Patients with Major Depressive Disorder: A Preliminary Analysis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Thomas Graven-Nielsen
Presenting Author: Annika Hou Winther
Submitting Author: Annika Winther

Description:

A leading cause of disability worldwide is depression (1), with substantial personal, societal, and economic consequences (2). Depression frequently co-occurs with chronic pain conditions (3) and is hypothesized to share overlapping mechanisms (4), including impaired endogenous pain modulation (5). Patients with major depressive disorder (MDD) paradoxically exhibit higher self-reported pain sensitivity (6), but also increased pain thresholds (7), yet the mechanisms underlying this altered pain processing remains poorly understood. Conditioned pain modulation (CPM); a psychophysical proxy measure of endogenous pain modulation (8), is known to be influenced by emotional processing (9) and psychological factors (10), but the current scarce heterogeneous evidence on endogenous pain modulation in MDD patients show contradictory findings (11–15). This study aims to compare CPM in MDD patients versus healthy controls and explore associations with attentional bias, depression severity, pain catastrophizing, anxiety severity, and psychological flexibility and inflexibility.

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Validity and Reliability of Conditioned Modulation of Pain Unpleasantness

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Yuri Martins Costa
Presenting Author: Rhayane da Conceição Monteiro
Submitting Author: Rhayane da Conceição Monteiro

Description:

Conditioned pain modulation (CPM) is commonly used to assess endogenous analgesia, with most paradigms emphasizing the sensory–discriminative dimension of pain. However, modulation of the affective dimension may provide complementary information, as pain intensity and unpleasantness, although related, do not necessarily converge. Incorporating affective outcomes may therefore refine the assessment of endogenous pain inhibition. This study aimed to examine the validity and reliability of CPM applied to the affective dimension of pain and to explore whether repeated measurements influence the psychometric properties of this paradigm.

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Characterization of the Nociceptive Blink Reflex: Implications for Orofacial Pain and Headache

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Yuri Martins Costa
Presenting Author: Yuri Martins Costa
Submitting Author: Yuri Costa

Description:

The nociceptive blink reflex (nBR) is a neurophysiological test that assesses brainstem-mediated responses and enables investigation of central pathways involved in trigeminal nociceptive processing. Its application may serve as an adjunctive tool in mechanism-based management of musculoskeletal orofacial pain, provided that robust reference values are established to identify neurophysiological alterations associated with distinct pain mechanisms. Characterizing nBR responses in healthy individuals is therefore essential to support clinical interpretation. The present study aimed to comprehensively characterize the psychophysical and electromyographic parameters of the nBR in a large sample of healthy adults.

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Sex differences in dynamic pain connectome periodic versus aperiodic alpha activity

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr. Karen D. Davis
Presenting Author: Sushmit Das
Submitting Author: Sushmit Das

Description:

Sex differences are important in pain research given disparities in chronic pain prevalence[1]. We previously reported sex-specific abnormalities in resting-state alpha oscillations in the dynamic pain connectome (DPC) in people with chronic pain[2-4]. However, interpretation is hindered because periodic and aperiodic components of the power spectral density (PSD) were not dissociated[5], and age-related effects were not considered in heterogenous cohorts. To establish a normative baseline for chronic pain interpretation, our study aim was to differentiate and characterize periodic vs aperiodic contributions to magnetoencephalography (MEG) resting-state alpha activity in the DPC using spectral parameterization[5] and evaluate sex-related differences.

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Salivary Microbiota and Network Changes in Oral Lichen Planus with Candida vs. Healthy Controls

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Hye-Min Ju
Presenting Author: Hye-Min Ju
Submitting Author: Hyemin Ju

Description:

Oral lichen planus (OLP) is a chronic immune-mediated mucosal disorder frequently accompanied by Candida colonization. However, the polymicrobial interactions and network alterations underlying this association remain poorly understood. This study aimed to characterize bacterial-fungal community changes and interkingdom network dynamics in OLP patients with confirmed Candida detection compared to healthy controls.

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Effects of Kinesio-taping versus connective tissue mobilisation in primary dysmenorrhea.

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr Amrit Kaur (PT)
Presenting Author: Dr Avani Bhavsar (PT)
Submitting Author: Avani bhavsar

Description:

Primary dysmenorrhea is a common condition in young women characterized by painful menstrual cramps without pelvic pathology, often accompanied by symptoms like nausea, fatigue, and low back pain that affect daily activities. While medications are commonly used, side effects encourage, the use of non-pharmacological methods. Physiotherapy techniques such as Kinesio-taping (KT) and Connective Tissue Mobilisation (CTM) are increasingly applied however, limited research compares their effectiveness in managing primary dysmenorrhea.

AIM

This study aimed to compare the effectiveness of KT and CTM in reducing menstrual pain and associated symptoms in females with primary dysmenorrhea.

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Brain-Muscles Network Decomposition in a Dynamic Upper-Limb Task With Acute Shoulder Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Graham Kerr
Presenting Author: Giacomo Nardese
Submitting Author: Giacomo Nardese

Description:

Shoulder movement requires coordinated neural drive to multiple muscles to achieve stable, accurate upper limb actions. Acute nociceptive input is known to modify motor behaviour [3,4], but how it reorganises functional coupling between the cortex and shoulder musculature during dynamic movement remains unclear [1]. Cortico-muscular and intermuscular coherence provide insight into shared neural control across the movement cycle. By characterising low dimensional brain–muscle networks [2] during a repetitive pointing task, this study examines how experimentally induced shoulder pain alters the organisation and timing of these networks when a larger set of ten upper limb muscles is considered.

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Acupuncture improves gait dysfunction and bone formation via ?2-adrenergic receptor signaling

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: In-Hyuk Ha
Presenting Author: Seok Hee Han
Submitting Author: SEOKHEE HAN

Description:

Bone defects and fractures involve damage to bone tissue or disruption of structural continuity and are associated with pain and reduced quality of life. Despite surgical treatment, 10–15% of cases result in delayed union or nonunion, highlighting the need for improved therapeutic strategies. The sympathetic nervous system regulates bone remodeling via β2-adrenergic receptor (β2AR) signaling in osteoblasts, promoting RANKL-mediated osteoclastogenesis. Although acupuncture is known to modulate autonomic nervous system activity, its role in bone regeneration and the underlying mechanisms remain unclear.

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Wearable EEG estimation of Blood Flow Restriction Walking Pain Intensity: Impact of Pain Sensitivity

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Seiji Okada
Presenting Author: Yuya Kanie
Submitting Author: Yuya Kanie

Description:

Pain assessment still relies largely on self report, which limits precise evaluation in clinical care. Objective brain based measures have been explored, but fMRI and conventional electroencephalography are constrained to resting conditions and are difficult to deploy in everyday clinical settings. We previously validated a wearable electroencephalography (EEG) system developed at our institution that can record stable signals during movement[1]. Using this device, we tested whether pain intensity during walking can be classified from spectral EEG features and whether individual pain sensitivity alters model performance under lower limb blood flow restriction. We hypothesized higher sensitivity yields clearer neural signatures.

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Paracervical block for postoperative pain following laparoscopic gynaecological surgeries

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Ashani Ratnayake
Presenting Author: Ashani Ratnayake
Submitting Author: Ashani Ratnayake

Description:

Postoperative pain following laparoscopic surgery remains clinically significant despite its minimally invasive nature. Regional analgesia can reduce perioperative opioid use. However, its routine use in laparoscopic gynaecological surgeries (LGS) remains unclear. Paracervical block (PCB) is a simple regional analgesia technique. It acts by blocking uterovaginal visceral afferent pathways. But its adoption remains limited in routine LGS, particularly in low-resource, high-volume centres. Data on its effect on postoperative pain trajectories and opioid consumption are scarce. This study evaluated the impact of lignocaine-based PCB on postoperative pain and related outcomes following LGS.

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THE EFFECT OF POST OP KETAMINE NEBULIZATION ON POST OP OPIOID REQUIRMENT IN LAPROSCOPIC SURGERIES

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr Minahil Zaman
Presenting Author: Dr Minahil Zaman
Submitting Author: Minahil Zaman

Description:

Postoperative pain following laparoscopic surgery is commonly managed with opioids, which carry significant risks including respiratory depression, apnea, nausea, and dependency. Ketamine, an NMDA receptor antagonist, has emerged as a promising opioid-sparing analgesic. It provides effective pain relief with sedative properties while causing bronchodilation rather than respiratory depression. Nebulized ketamine offers a non-invasive, rapid delivery route with 20–40% bioavailability compared to IV administration, and prior studies have demonstrated up to 50% pain relief without major side effects.
This study aims to assess the efficacy and safety of postoperative nebulized ketamine in reducing opioid consumption during the first 6 hours after general laparoscopic surgery, and to evaluate the duration of analgesia it provides. A randomized comparison between ketamine nebulization (1 mg/kg) and normal saline placebo will be conducted at National Hospital Lahore across 227 patients

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Latest Progress Of Preclinical And Clinical Studies On RFUS-949, A Novel Sigma-1 Receptor Antagonist

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Xin FANG
Presenting Author: Hao ZHOU
Submitting Author: Xin Fang

Description:

There is a critical need for new analgesics acting through new mechanisms with much less adverse events (AEs) to existing pain therapies. Sigma-1 receptor (S1R), a chaperone protein highly expressed in different pain areas of central nervous system and peripheral nervous system, interacts and modulates the pain functionality of different receptors and ion channels. Recently, S1R has become a focus point of new drug discovery for a therapeutic target as the potential non-opioid analgesics for inflammatory and neuropathic pain, as its antagonists effectively ameliorate pain in both preclinical and clinical studies.

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Opioid-Free vs Opioid-Based Anesthesia for Postoperative Analgesia in Laparoscopic Urologic Surgery

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Shipra Aggarwal
Presenting Author: Shradha Prasad
Submitting Author: Shradha Prasad

Description:

Recent advances in genitourinary surgery have transitioned from open procedures to minimally invasive laparoscopic techniques, enhancing visualization and minimizing tissue trauma. Although considered less painful, laparoscopic urological surgeries can still result in mild-to-moderate postoperative pain. Effective pain management is therefore essential, especially for elderly patients who are more susceptible to perioperative complications. Opioids have traditionally been used for postoperative analgesia but are linked to adverse effects such as respiratory depression, sedation, nausea, and dependence. [1,2] ERAS protocols recommend minimizing opioid use. [3] Opioid-free anesthesia, using multimodal non-opioid analgesics, provides effective pain control and may enhance postoperative recovery outcomes.

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Cancer Treatment Effects on Sensory and Pain Processing in children/adolescents - systematic review

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Miriam Kunz
Presenting Author: Miriam Kunz
Submitting Author: Miriam Kunz

Description:

Chemotherapy-induced peripheral neuropathy remains a major complication in pediatric cancer, with disrupted somatosensory and nociceptive processing being a key aspect (Bjornard et al., 2018; Ramchandren et al., 2009; Zajączkowska et al., 2019). This review synthesizes empirical studies on alterations in somatosensory and nociceptive processing in children and adolescents with cancer.

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Precision AI Medicine Platform for Analgesic Selection and Dose Optimization in Cancer Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Yacine HADJIAT
Presenting Author: Muhammad Kumail
Submitting Author: Yacine HADJIAT

Description:

Cancer pain remains highly heterogeneous, and opioid response varies substantially between patients. Current prescribing is largely iterative and based on empirical reassessment rather than patient-specific biological prediction. "PainRx" is a proposed translational platform designed to address this gap by combining patient-derived biological profiling with artificial intelligence–enabled drug prioritization and adaptive clinical dose optimization. The aim of this project is to repurpose the logic of functional precision medicine for cancer pain by developing a workflow that can use patient-derived samples to generate a biologic response profile, map that profile to candidate analgesic drugs or combinations, and then refine treatment through individualized clinical optimization. This abstract presents the scientific rationale, platform architecture, and Phase 1 methodology components of PainRx.

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Clinical Efficacy of Caudal Neuroplasty with Navigable Catheter in Refractory Chronic Low Back Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Silver Balcazar de Leon
Presenting Author: Italo Caro
Submitting Author: Italo Caro

Description:

Lumbar spinal stenosis is identified as a significant cause of refractory chronic low back pain. Often, conservative interventions do not provide sustained clinical benefits, leading to the application of interventional techniques such as neuroplasty. This study aimed to evaluate the association between neuroplasty using a navigable catheter and changes in pain levels in patients diagnosed with refractory chronic low back pain. Additionally, it explored demographic and clinical factors related to refractory chronic low back pain and their impact on the temporal evolution of pain.

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Evaluation of the Efficacy of Lidocaine 5% versus Capsaicin 0.075% patches in Postherpetic Neuralgia

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Prof Hammad Usmani
Presenting Author: Prof Hammad Usmani
Submitting Author: Hammad Usmani

Description:

Background: Postherpetic neuralgia (PHN) is a chronic neuropathic pain condition that significantly affects quality of life. Topical analgesic patches such as lidocaine and capsaicin provide localized pain relief with minimal systemic effects; however, comparative evidence regarding their efficacy and patient-centered outcomes is limited.
Aim: To compare the efficacy, patient satisfaction, and side-effect profile of a 5% lidocaine patch versus a 0.075% capsaicin patch in patients with postherpetic neuralgia of the thoracolumbar dermatome.

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Changes in ongoing regional brain activity and connectivity in Persistent Spinal Pain Syndrome

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Luke A. Henderson
Presenting Author: Allan Peng
Submitting Author: Allan Peng

Description:

Persistent Spinal Pain Syndrome (PSPS) describes chronic pain in the lower back or leg that is either present without prior spinal surgery (PSPS-Type 1) or following spinal surgery (PSPS-Type 2) (van de Minkelis et al., 2024). The mechanisms underpinning PSPS-T2 are complex and the specifics regarding on-going activity levels and patterns of neural activity in PSPS-T2 remain unclear. Thus, this study aimed to define regional cerebral blood flow and resting state functional connectivity in individuals with PSPS-T2 using arterial spin labelling (ASL), and resting state functional magnetic resonance imaging (fMRI), respectively.

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DRG Ischemia Induces Selective Proprioceptive Degeneration Underlying Chronic Postsurgical Leg Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Jiann-Her Lin
Presenting Author: Dinh-Thao Trinh
Submitting Author: Dinh Thao Trinh

Description:

Despite successful surgical decompression, 10–40% of patients with lumbar radiculopathy suffer from Chronic Post-Surgical Leg Pain (CPSLP). Our clinical data identifies preoperative foraminal stenosis (FS) as the strongest predictor of this chronicity. We hypothesize that FS creates a unique ischemic watershed within the dorsal root ganglion (DRG) due to its intrinsic vascular architecture. To validate this, we developed a mouse model that recapitulates FS, demonstrating that a chronicity threshold of 30-minute compression is sufficient to induce DRG hypoxia and persistent pain behaviors. This study aims to elucidate the cellular mechanisms linking this transient ischemic stress to long-term proprioceptive dysfunction.

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How Relationship Factors Shape Pain: Closeness and Solicitousness in Patient-Spouse Dyads

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Frauke Nees, Herta Flor
Presenting Author: Afton Bierlich
Submitting Author: Afton Bierlich

Description:

Pain behavior is shaped by social context, particularly partner behavior. Research shows that the presence of a solicitous partner affects pain ratings and neural processing (e.g., Nees et al., 2022), while attachment style also modulates pain responses, albeit in a different manner (Krahé et al., 2015). This raises the question about how broader relationship characteristics - and their relation to solicitousness – influence pain-related behaviors and neural processes in patient–spouse interactions. In the present study, we focused on interpersonal closeness (IC) and explored whether IC contributes to socially reinforced pain.

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When Complexity Fails: Chronic Pain Disrupts Cardiac Entropy�Cognition Coupling in Aging

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Ana María González-Roldán
Presenting Author: Alejandro Dorado
Submitting Author: Alejandro Dorado

Description:

Cardiac rhythm measures derived from heart rate variability (HRV), including time, frequency, and nonlinear indices, provide information about autonomic control and are associated with executive functioning and adaptive behavioral regulation¹. Chronic pain in older adults is linked to autonomic dysregulation and greater vulnerability to cognitive decline², yet how these processes interact remains unclear. We aimed to examine the relationship between cognitive performance and autonomic control in aging and its modulation by chronic pain. We hypothesized that, unlike pain-free older adults, those with chronic pain would show inverse associations between cognition and HRV indices, particularly nonlinear entropy and vagally mediated indices.

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Brain Activity Associated with Walking Pain Versus Pain Appraisal at Rest in Knee Osteoarthritis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Benedict Alter
Presenting Author: Benedict Alter
Submitting Author: Benedict Alter

Description:

Although preclinical models implicate brain processing in knee osteoarthritis (OA), brain mechanisms in patients are less understood. This is in part due to limitations in commonly used noninvasive brain imaging techniques, which rely on static supine positioning, a clear mismatch with clinical knee OA pain which is exacerbated by weight-bearing and ambulation. Functional near-infrared spectroscopy (fNIRS) shows promise as an ambulatory noninvasive brain imaging modality. However, nonneural hemodynamic changes during exercise complicate the interpretation of fNIRS signals. The aim of this study was to isolate pain-specific neural correlates of clinically relevant knee osteoarthritis pain during walking.

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Pain Education Outcomes in Caucasian Canadians and Visible Minorities with Persistent Shoulder Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Jean-Sébastien Roy
Presenting Author: Dayana Patricia Rosa
Submitting Author: Dayana Rosa

Description:

Rotator cuff-related shoulder pain (RCRSP) affects up to 70% of the population, with 40% reporting persistent symptoms after one year(1-4). Although pain is a multidimensional experience shaped by biological, emotional, cognitive, and sociocultural factors(5), the role of sociocultural diversity in pain processing remains understudied, contributing to reductionist treatment approaches(6). Immigrant-rich contexts such as Canada offer an opportunity to examine these influences. This study compared responses to a pain education (PE) self-management program between Caucasian Canadian adults and individuals from visible minorities groups living in Canada with RCRSP. Demographic and biopsychosocial variables were also examined to contextualize the sample at baseline.

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Multisensory Integration in chronic low-back pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: PD. Dr Jan Mehnert
Presenting Author: Dr. Einav Gozansky
Submitting Author: Einav Gozansky

Description:

Multisensory integration (MI) enhances perceptual reliability by combining information across sensory modalities and plays a fundamental role in everyday perception. Growing evidence indicates that MI is altered in certain chronic pain conditions, such as migraine and fibromyalgia. However, it remains unclear whether these alterations reflect a general characteristic of chronic pain or are specific to conditions in which non-nociceptive sensory processing is also affected. The present study examined pain-related MI in healthy individuals and in patients with chronic low back pain (cLBP), serving as an example of a chronic pain condition with prominent peripheral contributions and comparatively less central involvement.

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Comparing Different Treatment Options for Plantar Fasciitis, A Review Article

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Hossein Meskar
Presenting Author: Hossein meskar
Submitting Author: Hossein Meskar

Description:

Plantar fasciitis is a prevalent condition characterized by chronic heel pain,
primarily caused by inflammation of the plantar fascia. The condition significantly impairs
daily activities and quality of life, presenting a challenge for healthcare providers. Numerous
treatment modalities, ranging from conservative measures to invasive interventions, have
been explored to manage the symptoms and promote healing. However, the effectiveness of
these treatments, especially when combined, requires further evaluation.

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How Patients with Knee Osteoarthritis Regulate Everyday Physical Activity

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Petra von Heideken Wågert
Presenting Author: Johan Söderberg
Submitting Author: Johan Söderberg

Description:

Pain is commonly used in healthcare as a guide for regulating physical activity, despite evidence showing that pain is a poor indicator of tissue load or injury. Clinical recommendations to remain physically active may therefore be interpreted differently by patients living with long-term pain. As digital rehabilitation programmes increasingly support osteoarthritis management, understanding how individuals regulate activity in their everyday contexts becomes clinically important.

Aim: To explore how patients with knee osteoarthritis participating in a digital osteoarthritis rehabilitation programme regulate their everyday physical activity.

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Correlation between step count, physical activity level, and sedentary behavior in chronic neck pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Luiz Fernando Approbato Selistre
Presenting Author: Maria Ramela Schalch Vivaldini
Submitting Author: Maria Vivaldini

Description:

Accurate assessment of physical activity (PA) is essential for health monitoring in patients with musculoskeletal disorders. In individuals with chronic neck pain, objective measures from accelerometry and subjective data from questionnaires often capture different dimensions of movement. Therefore, understanding how these metrics relate is crucial for developing more precise clinical interventions that target both physical inactivity and sedentary behavior (SB) in this population. This study aims to investigate the correlation between objective step count, physical activity levels, and sedentary behavior specifically within a chronic neck pain population.

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Acute Effects of Kinesio Taping on Pain Threshold and Viscoelastic Properties in Patellofemoral Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Naime Uluğ
Presenting Author: Naime Uluğ
Submitting Author: Naime Ulug

Description:

Patellofemoral Pain Syndrome (PFPS) is a prevalent musculoskeletal condition affecting adolescents and young adults, yet its multifaceted etiology remains poorly elucidated (1). While Kinesio Taping (KT) is a prominent therapeutic modality in PFPS management (2), its acute implications for muscle viscoelastic properties (VEP)—including tone, stiffness, and elasticity—and pressure pain thresholds (PPT) warrant further investigation. Consequently, this study quantified the immediate impact of KT on VEP and PPT parameters in young adults with PFPS. By revealing these biomechanical and sensory adjustments, the research provides a critical perspective on the physiological mechanisms underlying KT’s clinical efficacy.

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Activation of Regions of Quadratus Lumborum during Functional Tasks: A Preliminary Case Series Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr. Prof. Wang Shwufen
Presenting Author: Sii, Joseph Ern-liang
Submitting Author: Sii Joseph, Ern-liang

Description:

Highest prevalence of Quadratus Lumborum (QL) myofascial dysfunction is reported among commonly affected muscles in patients with chronic low back pain (CLBP). Motor adaptation and movement strategy change due to pain or perception of pain has been shown in CLBP. Cadaveric and fine-wire EMG studies suggest distinct anatomical and functional roles of QL fascicles. Specifically, QL anterior (a) and QL posterior (p) lateral (L) region is the location of global iliocostal fibers, whereas the QLp medial (M) region is the location of local iliolumbar fibers. However, fine-wire EMG is invasive and not commonly available in clinical settings. Task-specific activation of distinct QL fascicles has not yet been investigated using ultrasonography. This preliminary in-vivo case series aimed to demonstrate task-specific activation patterns of QL fascicles in healthy participants using ultrasonography, which could lay the foundation to understand the compensation of muscle fibers of QL in patients with low back pain.

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Bertolotti s Syndrome - Prevalence in low back pain patients in an urban tertiary care centre

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr Arihant Jain
Presenting Author: Dr Shanal Alima
Submitting Author: Shanal Alima

Description:

Bertolotti syndrome (BS) or lumbosacral transitional vertebra (LSTV) syndrome first
identified by Bertolotti in 1917, is a common cause of lower back pain[1] The symptomatology extends from asymptomatic incidental finding to a constant source of a low backache in adolescent to middle-aged population. Presence of LSTV results in changes in biomechanics of load transmission resulting in significant morphological changes in various parts of spine, such as changes in width of lamina and cancellous bone content, reduced height of pars interarticularis, alteration in facet morphology, disc degeneration leading to LBP [2].The presence of an LSTV can result in pinching of a lumbar spinal nerve between the transverse process of the 5th lumbar vertebra and the sacral ala, a condition known as "Far-Out Syndrome" [6].
Aim of the study :1. To estimate the prevalence of BS in patients with LBP
2. To produce frequency estimates of BS, overall and for population subgroups.

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Interleukin 1 Receptor Antagonist Regulates Nerve to Sensory Neuron Signaling in Regeneration

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Euiheon Chung
Presenting Author: Emmanuel Acquah
Submitting Author: Emmanuel Acquah

Description:

Peripheral nerve injury triggers a robust inflammatory response that shapes axonal regeneration and functional recovery. Interleukin-1 signaling is a central mediator of neuroimmune communication between injured peripheral nerves and sensory neurons in the dorsal root ganglion. However, the role of its endogenous inhibitor, the interleukin-1 receptor antagonist, in regulating regenerative signaling remains unclear. We hypothesized that interleukin-1 receptor antagonist modulates inflammation-driven neuronal growth responses following nerve injury. The aim of this study was to determine whether modulation of interleukin-1 receptor antagonist alters cytokine expression within the injured nerve microenvironment and dorsal root ganglion, and to assess its effects on axonal regeneration and sensory outcomes. By integrating cytokine profiling, molecular analysis, and functional measurements, we sought to define the contribution of interleukin-1 receptor antagonist to neuroimmune signaling during peripheral nerve regeneration.

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Molecular Architecture of Mouse Spinoparabrachial Projection Neurons

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Andrew M. Bell
Presenting Author: Allen C. Dickie
Submitting Author: Allen Dickie

Description:

The anterolateral system (ALS) transmits pain, itch, and temperature information from the spinal cord to supraspinal centres and is essential for somatosensory perception. Despite its central importance, the cellular composition of this system remains poorly defined. Anatomical and functional studies indicate substantial heterogeneity among spinal projection neurons, yet the molecular identity of many cell types is unknown. Previous single-nucleus transcriptomic work from our group focused on Phox2a‑expressing projection neurons, identifying major molecular classes within the ALS (1). However, it remains unclear how these populations relate to the broader diversity of projection neurons. Here, we apply a similar methodology to characterise the entire spinoparabrachial tract in mice, enabling an unbiased analysis of projection neuron diversity in the dorsal horn.

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17-HDHA–associated transcriptomic signatures distinguish osteoarthritis pain phenotypes

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Victoria Chapman
Presenting Author: James Turnbull
Submitting Author: James Turnbull

Description:

Osteoarthritis (OA) is commonly associated with chronic pain that substantially affects daily life, although not all individuals with OA experience pain. Understanding these differences may reveal novel therapeutic targets. Specialised pro-resolving mediators (SPMs), including resolvins, are endogenous lipid molecules with potent analgesic properties. Resolvins are rapidly degraded in vivo, whereas their precursor, 17-hydroxydocosahexaenoic acid (17-HDHA) is more stable. We have previously shown that lower circulating 17-HDHA levels are associated with increased pain scores in people with OA. This study aimed to define the cellular and molecular mechanisms underlying 17-HDHA–mediated analgesia, with a focus on monocyte miRNA signalling.

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Whole-Brain Mapping Reveals Altered Pain Representations Following Early Life Adversity

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Kevin Beier
Presenting Author: May Hui
Submitting Author: May Hui

Description:

Chronic pain is a multifaceted condition shaped by numerous biological, psychological, and environmental factors. Among these, adverse childhood experiences (ACEs) have been consistently linked to increased susceptibility to chronic pain through long-lasting alterations in stress- and pain-processing circuits, including regions such as the insula, anterior cingulate cortex, and amygdala. Here, we investigate how an animal model of early life adversity (ELA) alters nociceptive processing and susceptibility towards developing neuropathic chronic pain following injury. Using behavioral assays, whole-brain activity mapping, and computational analyses in TRAP2 reporter mice before and after spared nerve injury (SNI), we aim to identify neural circuits through which ELA influences baseline nociception and chronic pain development.

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Flavonoids mitigate pain by interacting with TRPV1: Novel in -silico and in-vivo evidences

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Prof. Sanjit Dey
Presenting Author: Rimi Das
Submitting Author: Rimi Das

Description:

Transient receptor potential vanilloid 1 (TRPV1) is a key ion channel expressed in nociceptive sensory neurons that mediates pain signaling(1). It is activated by stimuli such as capsaicin, heat, and protons, leading to calcium influx, increased neuronal excitability, and release of pro-inflammatory cytokines and neuropeptides like CGRP and Substance P (2). Although TRPV1 is an important therapeutic target, current modulators (agonists, antagonists, and RNA interference) have limitations including pungency, desensitization, and thermoregulatory side effects (3). Capsazepine, a widely used antagonist, can induce hypothermia and requires high in vivo doses (3). This study aimed to identify safer and cost-effective agents with antinociceptive potential and to elucidate their mechanisms in inhibiting capsaicin-induced TRPV1 activation and its downstream signaling pathways.

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LOW BACK PAIN DURING PREGNANCY AND ITS IMPACT ON FUNCTIONAL CAPACITY OF PREGNANT WOMEN

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Sadaf Mushtaq
Presenting Author: Sadaf Mushtaq
Submitting Author: Sadaf Mushtaq

Description:

Low back pain (LBP) is a prevalent complaint among pregnant women(1), impairing functional capacity & quality of life. Many women encounter LBP for the first time during gestation, leading to various complications & disabilities(2). Nearly 80% of women have LBP throughout pregnancy(3). The intensity of discomfort hinders daily tasks(4). Weight, hormonal & biomechanical alterations render the mother vulnerable to LBP, pelvic pain, & sciatica. Most women experiencing LBP perceive it as a normal aspect of pregnancy, leading them to refrain from treatment. Untreated pain adversely affect mothers' emotional well-being(5) & post-pregnancy condition. The treatment strategies for these mothers should be considered(1). This study is to evaluate the prevalence & severity of LBP in our pregnant population, its effect on quality of life, & the extent of disability. We choose this work with the aim to contribute for a systematic review & meta-analysis of the global prevalence of LBP during pregnancy, serving as a crucial evidence to address it.

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“I reckon I could pedal for hours”: Experiences of Mediated Reality for Knee Osteoarthritis

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Tasha R Stanton
Presenting Author: Stephanie Dumuid
Submitting Author: Stephanie Dumuid

Description:

Exercise is effective for managing knee osteoarthritis (OA) pain. However, while exercise reduces pain in the long-term, it is often painful in the short-term, presenting a barrier to engagement. Mediated reality (MeR) shows promising effects in knee OA, with bodily illusions that alter the viewed morphology of the knee reducing pain by ~40% (1). MeR technology may allow people with knee OA to exercise with less pain, improving engagement. Despite its potential, clinical translation of an MeR intervention has yet to be explored. This qualitative study aimed to investigate participant experiences of a novel MeR, exercise, and pain-science education intervention.

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Impact of Migraine Treatment on Comorbid Temporomandibular Disorders

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Tara Renton
Presenting Author: Pankaew Yakkaphan
Submitting Author: Pankaew Yakkaphan

Description:

Temporomandibular disorders (TMD) are musculoskeletal conditions characterised by pain and functional limitations involving the masticatory muscles, temporomandibular joint, and associated orofacial structures. Migraine is among the most prevalent comorbidities in patients with TMD, and both conditions disproportionately affect women. Despite their frequent co-occurrence and overlapping symptomatology, which may contribute to misdiagnosis, the relationship between these conditions remains incompletely understood. Emerging evidence suggests shared pathophysiological mechanisms, as well as a potential bidirectional relationship between the two disorders. Previous studies have examined the effects of TMD treatment on migraine and the potential role of propranolol in managing facial pain. However, whether migraine directed treatment may benefit comorbid TMD has received limited attention. This study aimed to assess the impact of migraine treatment on TMD symptoms in patients with both conditions and to determine whether the onset and temporal patterns of co-occurrence between TMD and migraine are associated with treatment response.

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Reduced Cerebrospinal Fluid Draxin and FcRL2 in Chronic Postoperative Inguinal Pain

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Martin Flores Bjurström
Presenting Author: Alexander Rosenström
Submitting Author: Alexander Rosenström

Description:

Despite inguinal hernia repair being one of the most commonly performed surgical procedures worldwide, and high-impact chronic postherniorrhaphy inguinal pain (CPIP) affecting 1-3% of those operated upon [1], no previous study has examined neuroimmune mediators in the cerebrospinal fluid (CSF) of this patient population. Moreover, during the past two decades, neuroimmune signaling within the central nervous system (CNS) has emerged as a putative key mechanism underlying the development and maintenance of chronic neuropathic pain [2]. Data from preclinical models of neuropathic pain demonstrate elevated concentrations of proinflammatory cytokines, chemokines and neurotrophic factors at multiple levels of the neuraxis [3,4].

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Different Models, Different Narratives: Autoantibody Binding Divergence Across Pain Conditions

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: John M Dawes
Presenting Author: Omar Daifallah
Submitting Author: Omar Alzahrany

Description:

Neuropathic pain (NP), caused by damage or disease of the somatosensory system, is increasingly recognised as involving immune–neuronal interactions. Autoantibodies may contribute to NP by targeting neural structures and altering neuronal function without overt inflammation[1]. This is particularly relevant in idiopathic pain conditions, including idiopathic small fibre neuropathy (SFN), where autoantibodies have been reported[2,3], and Fibromyalgia Syndrome (FMS), in which patient IgG shows increased binding to sensory neurons compared with healthy controls (HC)[4]. This study aimed to screen patient and HC sera for IgG binding to live primary mouse DRG sensory neurons using an automated imaging pipeline, and to human induced pluripotent stem cell-derived sensory neurons (hIPSC-dSN).

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Trends in Postoperative Pain Control and Acute Pain Service Referral: A 5-Year Retrospective Study

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Ma. Lourdes K. Cabaluna
Presenting Author: Angela Dawn A. Chacon
Submitting Author: Angela Chacon

Description:

Postoperative pain remains a significant clinical challenge, with a large proportion of surgical patients experiencing inadequate pain control. Acute Pain Services (APS) aim to optimize perioperative pain management through structured assessment and targeted interventions. However, local data describing APS utilization, referral patterns, and pain outcomes over time remain limited. This study aimed to describe trends in postoperative pain control, APS referral duration, and utilization in a tertiary hospital in the Philippines.

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Molecular basis of TRPM3 – an ion channel involved in pain and brain disease

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Thomas Voets
Presenting Author: Bahar Bazeli
Submitting Author: Bahar Bazeli

Description:

Transient Receptor Potential melastatin 3 (TRPM3) is a temperature-sensitive ionotropic neurosteroid receptor within the TRP superfamily of cation channels. In the peripheral nervous system, TRPM3 is expressed and contributes to the detection of noxious heat. Under pathological conditions such as inflammation or neuropathy, TRPM3 channel activity is increased, contributing to sensory hypersensitivity and ongoing pain. In addition, TRPM3 is expressed in various neuronal and non-neuronal cells in the developing and adult brain, but its role in brain function is not well established. Notably, gain-of-function mutations in TRPM3 cause a spectrum of neurodevelopmental disorders, characterized by a variety of neurological symptoms, including developmental delay, hypotonia, seizures and often alterations in heat- or pain sensitivity. Therefore, strategies to modify TRPM3 activity represent important new therapeutic avenues to treat pathological pain and brain disorders. Despite the therapeutic promise of TRPM3 antagonists, the molecular mechanisms by which ligands modulate channel gating remain poorly understood.

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Theta Oscillations in Fibromyalgia: Repetition-Related Rather Than tACS-Specific Effects

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Pedro José Montoya Jiménez
Presenting Author: Behzad Rostami Sani
Submitting Author: Behzad Rostami Sani

Description:

Background: Fibromyalgia is increasingly understood as a disorder involving altered central pain processing, with pain-related, affective, and cognitive dimensions interacting in the central nervous system. Neuroimaging studies highlight the relevance of regions involved in pain processing, including somatosensory, prefrontal, cingulate, and insular areas, although findings remain heterogeneous across modalities and designs. Theta-band activity is also closely linked to cognitive control and task demands, with frontal-midline theta increasing when greater control is required. Transcranial alternating current stimulation may influence cortical oscillations in a frequency-specific manner, making it a candidate tool for probing oscillatory mechanisms in chronic pain.
Objective: This study examined whether tACS modulates theta-band event-related oscillations during an implicit affective-cognitive task in patients with fibromyalgia.

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Nanocarrier Technology for Peripheral Pain Treatment: Proof of Concept and Safety Studies in Vivo

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr. Sam Dylan Moré
Presenting Author: Dr. Sam Dylan Moré
Submitting Author: Sam Dylan Moré

Description:

Dendritic nanocarriers based on functionalized polyglycerol were loaded with κ-opioid agonist / µ-antagonist Nalbuphine, aiming to target exclusively peripheral opioid receptors. This strategy offers a promising approach for managing post-operative and neuropathic pain while minimising central adverse effects. Peripherally restricted agonists can provide effective analgesia at the site of tissue injury by reducing nociceptor excitability and inflammatory signalling without significantly crossing the blood–brain barrier (Stein,C, 2009, 2016). This approach may decrease risks such as respiratory depression, sedation, and addiction associated with centrally acting opioids. Additionally, κ-receptor agonists may reduce visceral and inflammatory pain with lower abuse potential. (Vadivelu N. 2010; Spetea M. 2012; Zöllner C. and Stein C. 2007, Kalso, E. 2025)
Fluorescence marked carriers exhibited a preferential accumulation of opioid nano pro-drugs in inflamed peripheral tissue. Safety studies in mini-pig and rodents were carried out to demonstrate that dendritic nanocarriers loaded with opioids can be a safe approach to developing drugs for peripheral pain treatment.

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Scaling Palliative Care Capacity in North India: A Multicenter Capacity Building Model

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Dr Sushma Bhatnagar
Presenting Author: Dr Sushma Bhatnagar
Submitting Author: Sushma Bhatnagar

Description:

Palliative care (PC) provision in Northern India remains limited and uneven despite a steadily increasing need. The demand for specialized care that prioritizes quality of life is urgent, driven by factors like an aging population and a significant rise in noncommunicable diseases. In this context, PC providers frequently lack adequate training, institutional support, and interdisciplinary collaboration indispensable for effective implementation of PC. This study analyzes the effectiveness of a PC capacity-building project executed from 2023 through 2025. The aim was to present scalable approaches to enhance PC competencies, overcome existing barriers, and expand PC infrastructure in Northern India.

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The pursuit of motivational goals reduces pain through an opioidergic mechanism

Date: 28/10/2026 Time: 03:15 PM - 04:45 PM

Senior Author: Christian Büchel
Presenting Author: Leonard Asan
Submitting Author: Leonard Asan

Description:

Pain acts as a motivational signal to protect the organism from further harm. At the same time, it can conflict with the pursuit of other behaviorally relevant goals. The motivation–decision framework (Fields, 2006) proposes that choosing to pursue an alternative motivational goal attenuates pain via engagement of the descending pain modulatory system (DPMS). We tested whether actively deciding to pursue a motivational goal reduces pain in humans and whether this effect depends on endogenous opioids.

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Poster Session 4 (Wednesday Afternoon)

Description

Session Type: Posters
Room: Exhibit Hall EH102-103

28/10/2026 3:15 PM - 4:45 PM